INT54924

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 67
Total Number 72
Disease Relevance 83.20
Pain Relevance 14.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
foramen ovale 2
limb 2
covering 1
Brain 1
ergot 1
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 393 100.00 Very High Very High Very High
cva 138 100.00 Very High Very High Very High
Restless leg syndrome 12 100.00 Very High Very High Very High
phantom pain 5 99.88 Very High Very High Very High
Dopamine 600 99.84 Very High Very High Very High
sSRI 26 99.78 Very High Very High Very High
peripheral neuropathy 51 99.18 Very High Very High Very High
Gabapentin 257 99.12 Very High Very High Very High
phantom limb 1 99.12 Very High Very High Very High
imagery 27 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 5007 100.00 Very High Very High Very High
Sleep Disorders 663 100.00 Very High Very High Very High
Depression 494 100.00 Very High Very High Very High
Patent Foramen Ovale 341 100.00 Very High Very High Very High
Disease 337 100.00 Very High Very High Very High
Paradoxical Embolism 66 100.00 Very High Very High Very High
Pulmonary Embolism 60 100.00 Very High Very High Very High
Thrombosis 54 100.00 Very High Very High Very High
Aneurism 42 100.00 Very High Very High Very High
Cv General 4 Under Development 24 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: RLS was present in 41/102 patients (40.2%).
Gene_expression (present) of RLS
1) Confidence 0.62 Published 2009 Journal Pain Med Section Body Doc Link 20021603 Disease Relevance 0.30 Pain Relevance 0
The RLS symptoms returned after subsequent reductions in the dosage.
Gene_expression (returned) of RLS
2) Confidence 0.59 Published 1994 Journal Ann Pharmacother Section Body Doc Link 7949505 Disease Relevance 0.16 Pain Relevance 0
Of 15 patients with moderate to severe RLS, all of whom had bilateral physical findings of neuromas, treatment with injections or surgery resulted in sustained remission of RLS in nine with a concomitant marked improvement in subjective sleep quality and fatigue, indicating that their RLS was of peripheral (neuroma) origin [7].
Gene_expression (remission) of RLS associated with fatigue, neuroma and restless legs syndrome
3) Confidence 0.58 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2949698 Disease Relevance 2.16 Pain Relevance 0.16
A diagnosis of RLS was also made in 60 cases during phase 2.
Gene_expression (diagnosis) of RLS
4) Confidence 0.58 Published 2009 Journal Neurol India Section Body Doc Link 20139500 Disease Relevance 0.19 Pain Relevance 0
We found, in a large questionnaire study (n=283) on phantom limb perception, a pattern of phantom pain that resembled RLS: amputees with nocturnal phantom pain were more likely to report worse pain upon rest and/or lying down, with an urge to move the phantom and/or walk to relieve their pain, and to experience spontaneous limb movements akin to periodic leg movements of RLS.
Gene_expression (resembled) of RLS in limb associated with pain, phantom limb, restless legs syndrome and phantom pain
5) Confidence 0.58 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 20071104 Disease Relevance 1.56 Pain Relevance 0.97
A latent RLS was found in 28%, a permanent RLS in 72%, a shower-curtain pattern was detected in 52% of the studied patients.
Gene_expression (found) of RLS associated with restless legs syndrome
6) Confidence 0.58 Published 2009 Journal Neurol. Sci. Section Abstract Doc Link 19415438 Disease Relevance 1.08 Pain Relevance 0.16
A latent RLS was found in 28%, a permanent RLS in 72%, a shower-curtain pattern was detected in 52% of the studied patients.
Gene_expression (found) of RLS associated with restless legs syndrome
7) Confidence 0.58 Published 2009 Journal Neurol. Sci. Section Abstract Doc Link 19415438 Disease Relevance 1.08 Pain Relevance 0.16
All studies published after 1996, which attempted to assess RLS augmentation, were reviewed in a separate section.
Gene_expression (augmentation) of RLS associated with restless legs syndrome
8) Confidence 0.58 Published 2008 Journal Mov. Disord. Section Abstract Doc Link 18925578 Disease Relevance 0.57 Pain Relevance 0.42
The problem is most pronounced with mirtazapine provoking or deteriorating RLS in 28% of patients.
Gene_expression (pronounced) of RLS associated with restless legs syndrome
9) Confidence 0.58 Published 2008 Journal J Psychiatr Res Section Abstract Doc Link 18468624 Disease Relevance 0.66 Pain Relevance 0.45
Chronic conditions such as diabetes, peripheral neuropathy, and Parkinson's disease can worsen and prolong RLS symptoms.
Gene_expression (prolong) of RLS associated with diabetes mellitus, peripheral neuropathy, restless legs syndrome and disease
10) Confidence 0.58 Published 2000 Journal Geriatrics Section Abstract Doc Link 10771701 Disease Relevance 1.00 Pain Relevance 0.22
Ancillary testing is not necessary to establish the diagnosis of RLS, except in situations where secondary RLS (eg, ferritin and transferrin levels for iron deficiency, BUN and creatinine for renal failure) is suspected or when other possible disorders need to be excluded.
Gene_expression (diagnosis) of RLS associated with anaemia, renal failure and restless legs syndrome
11) Confidence 0.58 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 1.20 Pain Relevance 0
Ancillary testing is not necessary to establish the diagnosis of RLS, except in situations where secondary RLS (eg, ferritin and transferrin levels for iron deficiency, BUN and creatinine for renal failure) is suspected or when other possible disorders need to be excluded.
Gene_expression (levels) of RLS associated with anaemia, renal failure and restless legs syndrome
12) Confidence 0.58 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 1.33 Pain Relevance 0
Ancillary testing is not necessary to establish the diagnosis of RLS, except in situations where secondary RLS (eg, ferritin and transferrin levels for iron deficiency, BUN and creatinine for renal failure) is suspected or when other possible disorders need to be excluded.
Gene_expression (diagnosis) of RLS associated with anaemia, renal failure and restless legs syndrome
13) Confidence 0.58 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 1.32 Pain Relevance 0
Cognitive effects of RLS
Gene_expression (effects) of RLS associated with cognitive disorder and restless legs syndrome
14) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.70 Pain Relevance 0.07
Effects in primary RLS
Gene_expression (primary) of RLS associated with restless legs syndrome
15) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.05 Pain Relevance 0.12
Effects in primary RLS
Gene_expression (Effects) of RLS associated with restless legs syndrome
16) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.06 Pain Relevance 0.12
This choice is partly based on the potential association between the use of other antidepressants, particularly the selective serotonin reuptake inhibitors (SSRIs), and the appearance of RLS.
Gene_expression (appearance) of RLS associated with antidepressant, restless legs syndrome and ssri
17) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.82 Pain Relevance 0.60
Relationship between RLS symptoms and mood disorders
Gene_expression (symptoms) of RLS associated with affective disorder and restless legs syndrome
18) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 2.67 Pain Relevance 0.33
A practical treatment approach for RLS and depression is suggested by Picchietti and Winkelman (2005).
Gene_expression (depression) of RLS associated with depression and restless legs syndrome
19) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.87 Pain Relevance 0.85
Effects of RLS on patientsÂ’ QoL
Gene_expression (Effects) of RLS associated with restless legs syndrome
20) Confidence 0.57 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 1.05 Pain Relevance 0.13

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