INT54934

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Context Info
Confidence 0.08
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.48
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SMC 2
Smooth muscle cells 1
platelet 1
neutrophil 1
smc (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 12 99.80 Very High Very High Very High
antagonist 6 96.28 Very High Very High Very High
agonist 2 91.76 High High
depression 1 87.68 High High
Inflammation 24 84.48 Quite High
nMDA receptor 6 84.24 Quite High
excitatory amino acid 2 82.96 Quite High
cytokine 20 76.56 Quite High
cva 3 74.64 Quite High
Percutaneous transluminal coronary angioplasty 1 26.24 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 9 99.24 Very High Very High Very High
Adhesions 21 99.16 Very High Very High Very High
Cardiovascular Disease 17 92.12 High High
Depression 1 87.68 High High
Atherosclerosis 22 87.52 High High
INFLAMMATION 26 84.48 Quite High
Thrombosis Related Under Development 10 83.88 Quite High
Hemorrhage 3 74.64 Quite High
Neointima 17 73.76 Quite High
Hyperplasia 7 71.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous report demonstrated that the mechanism of the antimitogenic effect of fucoidan was different from that of heparin, which also inhibits SMC growth [18].
Negative_regulation (inhibits) of SMC
1) Confidence 0.08 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.47 Pain Relevance 0.18
However in the presence of either 7-chlorokynurenate or high currents of CNQX that reduced the SMC synaptic activation of the mRN neurones, D-serine attenuated the inhibitory action of these antagonists.
Negative_regulation (reduced) of SMC in SMC associated with antagonist
2) Confidence 0.08 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953653 Disease Relevance 0 Pain Relevance 0.74
At currents that selectively antagonised NMDA responses, CPPene had no effect on either SMC or IPN responses. 7-chlorokynurenate inhibited both SMC and IPN responses but required currents that antagonised both AMPA and NMDA responses and was therefore acting in a non-selective manner.
Negative_regulation (inhibited) of SMC in SMC associated with ipn
3) Confidence 0.08 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953653 Disease Relevance 0 Pain Relevance 0.65
For mPGES-1, expression was mild in renal vascular SMC and EC,
Negative_regulation (mild) of SMC
4) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
Furthermore, 72 hours after beginning of resuscitation neutrophil counts were significantly reduced in the LIM group compared to SMC (p < 0.05).
Negative_regulation (reduced) of SMC in neutrophil
5) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873502 Disease Relevance 0.16 Pain Relevance 0.08
Smooth muscle cells in the media are enveloped by a basement membrane mainly composed of collagen IV and laminin, preventing SMC from proliferation and migration and keeping SMC in a contractile state [15–17].
Negative_regulation (preventing) of SMC in Smooth muscle cells
6) Confidence 0.03 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.13 Pain Relevance 0
Prostacylin

(PGI2), nitric oxide (NO) and thrombin inhibitors all act through the inhibition of platelet adhesion and aggregation, in conjunction with the prevention of vascular SMC proliferation and vasoconstriction.

Negative_regulation (prevention) of SMC in platelet associated with increased venous pressure under development and adhesions
7) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.72 Pain Relevance 0

General Comments

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