INT54938

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2009
Negated 0
Speculated 4
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 4.41
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) DNA binding (Rb1)
cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
dentate gyrus 4
Rb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 36 99.84 Very High Very High Very High
anesthesia 9 99.74 Very High Very High Very High
Central nervous system 5 98.24 Very High Very High Very High
Pain 69 97.12 Very High Very High Very High
substance P 7 94.12 High High
Antinociceptive 2 75.00 Quite High
Inflammation 4 73.28 Quite High
Spinal cord 1 52.16 Quite High
antinociception 1 26.80 Quite Low
Analgesic 22 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 36 99.72 Very High Very High Very High
Pain 64 97.12 Very High Very High Very High
Nociception 4 95.40 Very High Very High Very High
Necrosis 5 88.20 High High
Cancer 49 88.08 High High
Glioma 24 82.68 Quite High
Targeted Disruption 16 79.28 Quite High
Death 52 78.64 Quite High
Anaerobic Bacterial Infections 12 78.28 Quite High
Colon Cancer 1 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats.
Regulation (effects) of Rb1 in dentate gyrus associated with anesthesia and long-term potentiation
1) Confidence 0.44 Published 1994 Journal Brain Res. Section Title Doc Link 7953656 Disease Relevance 0.22 Pain Relevance 0.48
Differential effects of ginsenoside Rb1 and malonylginsenoside Rb1 on long-term potentiation in the dentate gyrus of rats.
Regulation (effects) of Rb1 in dentate gyrus associated with anesthesia and long-term potentiation
2) Confidence 0.44 Published 1994 Journal Brain Res. Section Title Doc Link 7953656 Disease Relevance 0.21 Pain Relevance 0.48
In the present study, we investigated the effects of ginsenoside Rb1 (GRb1) and malonylginsenoside Rb1 (GRb1-m) on the induction of long-term potentiation (LTP) in the dentate gyrus using anesthetized rats.
Spec (investigated) Regulation (effects) of Rb1 in dentate gyrus associated with long-term potentiation
3) Confidence 0.44 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953656 Disease Relevance 0.19 Pain Relevance 0.28
In the present study, we investigated the effects of ginsenoside Rb1 (GRb1) and malonylginsenoside Rb1 (GRb1-m) on the induction of long-term potentiation (LTP) in the dentate gyrus using anesthetized rats.
Spec (investigated) Regulation (effects) of Rb1 in dentate gyrus associated with long-term potentiation
4) Confidence 0.44 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953656 Disease Relevance 0.20 Pain Relevance 0.31
Up to 50% of the PRAB positive cells in the OvxC group are PRB positive, thus indicating that there are cells containing both PRA and PRB in the OvxC group.
Regulation (positive) of PRB
5) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.22 Pain Relevance 0
Changes in PRB levels did not differ from PRAB, thus PRB seems to be the dominating PR subtype in LE.
Regulation (Changes) of PRB
6) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.12 Pain Relevance 0
We have examined the effects of several ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and Rg3) administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on the nociceptive behavior induced by substance P (0.7 microg) injected i.t.
Spec (examined) Regulation (effects) of Rb1 associated with nociception and substance p
7) Confidence 0.18 Published 2003 Journal Planta Med. Section Abstract Doc Link 14735436 Disease Relevance 0.31 Pain Relevance 0.26
Information on the number of patients with at least 50%maxTOTPAR for active treatment and placebo was then used to calculate relative benefit (RB) and number needed-to-treat (NNT).
Regulation (calculate) of RB
8) Confidence 0.15 Published 2008 Journal BMC Clin Pharmacol Section Body Doc Link PMC2585070 Disease Relevance 0.75 Pain Relevance 0.81
Increased p53 expression together with these changes in pRb and cyclin D1 can significantly increase cell apoptosis [37-39].
Regulation (changes) of pRb associated with apoptosis
9) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.92 Pain Relevance 0
Pro-apoptotic genes, associated to the intrinsic apoptotic pathway, are regulated after IONT and IONC (14–3–3, RAD9, RASSF4, Rb protein, Smad4, PPM1B), although IONT (BMF, Bcl.10, Bax, Bcl-B, DLC1, MCL1) seems to trigger a higher response than IONC does.
Spec (seems) Regulation (regulated) of Rb protein associated with apoptosis
10) Confidence 0.00 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.29 Pain Relevance 0.06

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