INT54969

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1a1) response to stress (Sult1a1) cytoplasm (Sult1a1)
Anatomy Link Frequency
platelet 2
liver 1
Sult1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 14 99.54 Very High Very High Very High
Paracetamol 166 99.16 Very High Very High Very High
Catecholamine 3 98.12 Very High Very High Very High
Migraine 2 95.36 Very High Very High Very High
monoamine 2 73.08 Quite High
5HT 2 58.56 Quite High
Dopamine 3 53.56 Quite High
Inflammation 35 50.00 Quite Low
cytokine 25 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 12 99.16 Very High Very High Very High
Migraine Without Aura 2 95.36 Very High Very High Very High
Toxicity 19 90.72 High High
Overdose 9 86.88 High High
Liver Failure 1 85.92 High High
Stress 2 63.72 Quite High
Adhesions 39 63.68 Quite High
Hepatotoxicity 5 52.16 Quite High
INFLAMMATION 50 50.00 Quite Low
Apoptosis 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a wash to remove any unbound substances and/or antibody enzyme reagent, substrate solution was added to the wells allowing the colorometic reaction in proportion to the amount of sTF, sTM and D-D bound.
sTM Binding (bound) of
1) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.12 Pain Relevance 0
We investigated platelet 3H-imipramine (3H-IMI) binding, a putative peripheral serotonergic marker, and the activity of sulphotransferase (ST), an enzyme involved in the catabolism of catecholamines and phenolic compounds, in 14 patients suffering from migraine without aura (MWoA) and in 10 with tension-type headache (TH), as compared with a group of controls.
sulphotransferase Binding (binding) of in platelet associated with migraine, catecholamine and headache
2) Confidence 0.12 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954741 Disease Relevance 0.36 Pain Relevance 0.43
Platelet 3H-imipramine binding and sulphotransferase activity in primary headache.
sulphotransferase Binding (binding) of in Platelet associated with headache
3) Confidence 0.09 Published 1994 Journal Cephalalgia Section Title Doc Link 7954741 Disease Relevance 0.48 Pain Relevance 0.72
Acetaminophen is mainly metabolised, in the liver, via conjugation by sulphotransferase and UDP-glucuronosyltransferase and then excreted, but a small fraction of it is metabolised by CYP2E1 [7], [35].
sulphotransferase Binding (conjugation) of in liver associated with paracetamol
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.44 Pain Relevance 1.02

General Comments

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