INT5497

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2011
Negated 12
Speculated 14
Reported most in Abstract
Documents 299
Total Number 314
Disease Relevance 125.54
Pain Relevance 131.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
PVN 29
neurons 19
hypothalamus 16
plasma 16
brain 12
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 162 100.00 Very High Very High Very High
Enkephalin 155 100.00 Very High Very High Very High
Opioid 149 100.00 Very High Very High Very High
Catecholamine 87 100.00 Very High Very High Very High
Dynorphin 49 100.00 Very High Very High Very High
Endogenous opioid 34 100.00 Very High Very High Very High
Somatostatin 33 100.00 Very High Very High Very High
opioid receptor 26 100.00 Very High Very High Very High
electroacupuncture 408 99.98 Very High Very High Very High
Morphine 290 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 1241 100.00 Very High Very High Very High
Stress 1206 100.00 Very High Very High Very High
Hypoglycemia 35 100.00 Very High Very High Very High
Hyperemia 22 100.00 Very High Very High Very High
Heat Stress Disorders 3 100.00 Very High Very High Very High
Rheumatoid Arthritis 293 99.96 Very High Very High Very High
Injury 92 99.88 Very High Very High Very High
Inflammatory Pain 20 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 29 99.82 Very High Very High Very High
Sleep Disorders 89 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is hypothesized that stress-induced CRH activation is attenuated by the enhancement of the inhibitory GABAergic system activity associated with etifoxine.
Positive_regulation (activation) of CRH associated with stress and gabaergic
1) Confidence 0.70 Published 2004 Journal Physiol. Behav. Section Abstract Doc Link 15451655 Disease Relevance 1.05 Pain Relevance 0.14
To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent animals injected with saline or 5 mg/kg naloxone.
Positive_regulation (induction) of CRH in hypothalamus associated with narcan, withdrawal, opioid and morphine
2) Confidence 0.70 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286593 Disease Relevance 0.17 Pain Relevance 1.05
To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent animals injected with saline or 5 mg/kg naloxone.
Positive_regulation (induction) of corticotropin-releasing hormone in hypothalamus associated with narcan, withdrawal, opioid and morphine
3) Confidence 0.70 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286593 Disease Relevance 0.17 Pain Relevance 1.05
The activation of intracerebral corticotropin releasing factor (CRF) system is involved in nitrous oxide analgesia.
Positive_regulation (activation) of corticotropin releasing factor associated with analgesia
4) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.23
We evaluated the effect of general anesthetics on nitrous-oxide-induced CRF activation and antinociception.
Positive_regulation (activation) of CRF associated with antinociception
5) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.36
Both inhaled isoflurane and intravenous propofol inhibited nitrous-oxide-induced activation of CRF neurons, suggesting that these general anesthetics may inhibit one of the analgesic mechanisms of nitrous oxide.
Positive_regulation (activation) of CRF in neurons associated with analgesic and isoflurane
6) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.56
The activation of intracerebral corticotropin releasing factor (CRF) system is involved in nitrous oxide analgesia.
Positive_regulation (activation) of CRF associated with analgesia
7) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.23
General anesthetics inhibit the nitrous-oxide-induced activation of corticotropin releasing factor containing neurons in rats.
Positive_regulation (activation) of corticotropin releasing factor in neurons
8) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.49
Thus, while acute stress increases levels of thalamic CRH mRNA, repeated exposure to the same stressor is without effect and prevents the acute response.
Positive_regulation (increases) of CRH associated with stress
9) Confidence 0.70 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.79 Pain Relevance 0.07
Acute stress-induced increases in thalamic CRH mRNA are blocked by repeated stress exposure.
Positive_regulation (increases) of CRH associated with stress and pain
10) Confidence 0.70 Published 2001 Journal Brain Res. Section Title Doc Link 11578616 Disease Relevance 0.77 Pain Relevance 0.27
Compared to the no stress condition, acute restraint significantly increased CRH mRNA in the Po (39%) and the CM-VPMpc (32%).
Positive_regulation (increased) of CRH associated with stress
11) Confidence 0.70 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.89 Pain Relevance 0.08
Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms.
Positive_regulation (activation) of corticotropin-releasing factor associated with stress, addiction and opioid
12) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Title Doc Link 12223538 Disease Relevance 0.46 Pain Relevance 0.27
An increase of CRH mRNA in the paraventricular nucleus of the hypothalamus was specific to rats undergoing withdrawal.
Positive_regulation (increase) of CRH mRNA in nucleus associated with withdrawal
13) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 12074902 Disease Relevance 0.28 Pain Relevance 1.37
Our findings of an increase in amygdalar CRH gene expression during early cocaine withdrawal support a potentially important role for amygdalar CRH activity in the anxiogenic and aversive consequences of withdrawal from cocaine during a time when humans are most subject to relapse.
Positive_regulation (role) of CRH associated with withdrawal, recurrence and cocaine
14) Confidence 0.70 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.29 Pain Relevance 1.01
There was also a significant elevation of CRH mRNA levels in the amygdala, but not in the hypothalamus, frontal cortex or brainstem after 2-day cocaine withdrawal.
Positive_regulation (elevation) of CRH in hypothalamus associated with medulla, urological neuroanatomy, withdrawal, amygdala and cocaine
15) Confidence 0.70 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.34 Pain Relevance 1.03
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine.
Positive_regulation (Increased) of CRH in amygdala associated with enkephalin, withdrawal, amygdala and cocaine
16) Confidence 0.70 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12782395 Disease Relevance 0.30 Pain Relevance 0.80
Circulating corticosterone and CRF mRNA were increased in all three strains following either stress.
Positive_regulation (increased) of CRF mRNA associated with stress and sprains and strains
17) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 7895084 Disease Relevance 1.14 Pain Relevance 0
We have investigated the hypothalamic activation of corticotrophin-releasing factor (CRF) and proenkephalin A (PEA) mRNAs in the parvocellular cells of the paraventricular nucleus (PVN) and arginine vasopressin (AVP) in both the magnocellular and parvocellular regions in the PVN following acute stress.
Spec (investigated) Positive_regulation (activation) of CRF in PVN associated with stress
18) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 7895084 Disease Relevance 1.09 Pain Relevance 0
We have investigated the hypothalamic activation of corticotrophin-releasing factor (CRF) and proenkephalin A (PEA) mRNAs in the parvocellular cells of the paraventricular nucleus (PVN) and arginine vasopressin (AVP) in both the magnocellular and parvocellular regions in the PVN following acute stress.
Spec (investigated) Positive_regulation (activation) of corticotrophin-releasing factor in PVN associated with stress
19) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 7895084 Disease Relevance 1.08 Pain Relevance 0
These data indicate that capsaicin-sensitive splanchnic afferent fibers and activation of CRF receptors in the brain are part of the neuronal circuitry mediating gastric stasis 3 h after abdominal surgery.
Positive_regulation (activation) of CRF in neuronal associated with gastroparesis and qutenza
20) Confidence 0.70 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8967419 Disease Relevance 0.26 Pain Relevance 0.39

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