INT54978

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 14.97
Pain Relevance 7.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
myocyte 2
plasma 2
esophagus 2
smooth muscle cells 2
muscle 1
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 86 100.00 Very High Very High Very High
Pain 80 100.00 Very High Very High Very High
anesthesia 1 100.00 Very High Very High Very High
Opioid 33 99.96 Very High Very High Very High
agonist 120 99.80 Very High Very High Very High
antagonist 425 99.64 Very High Very High Very High
nociceptor 15 99.60 Very High Very High Very High
Cannabinoid 21 99.48 Very High Very High Very High
Neurotransmitter 11 99.44 Very High Very High Very High
orphanin 4 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 268 100.00 Very High Very High Very High
Pain 91 100.00 Very High Very High Very High
Cancer 459 99.32 Very High Very High Very High
Apoptosis 124 99.04 Very High Very High Very High
Osteoporosis 116 99.04 Very High Very High Very High
Bordatella Infection 13 98.88 Very High Very High Very High
Pulmonary Hypertension 533 97.76 Very High Very High Very High
Heart Rate Under Development 9 97.68 Very High Very High Very High
Pressure And Volume Under Development 40 97.08 Very High Very High Very High
Disease 238 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autoradiography demonstrated specific binding of 125I-ET-1 to the muscularis mucosae and muscularis propria (muscularis externa) of the human esophagus.
ET Binding (binding) of in esophagus
1) Confidence 0.41 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.21
To investigate effects of ET in the human esophagus, we measured contraction of isolated human esophageal muscularis mucosae strips caused by ET related peptides and binding of 125I-ET-1 to cell membranes prepared from the human esophageal muscularis mucosae.
ET Binding (binding) of in esophagus
2) Confidence 0.41 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.13
Binding of 125I-ET-1 to cell membranes of the muscularis mucosae was saturable and specific.
ET Binding (Binding) of
3) Confidence 0.41 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.24
Bosentan is an orally available, nonpeptide endothelin receptor antagonist that blocks both ET-A and ET-B receptors.
ET-A Binding (receptors) of associated with antagonist
4) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.85 Pain Relevance 0.29
This study demonstrates that, the muscularis mucosae of the human esophagus, similar to that of the guinea pig esophagus, possesses both ETA and ETB receptors mediating muscle contraction.
ETA Binding (possesses) of in muscle
5) Confidence 0.36 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.20
In the brain, at least two types of specific subreceptors have been cloned; ETA receptors, exclusively associated with blood vessels and ETB receptors also found on glial, epithelial, and ependymal cells.
ETA Binding (associated) of in ependymal cells
6) Confidence 0.35 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954753 Disease Relevance 0.41 Pain Relevance 0.03
Analysis of dose-inhibition curves demonstrated the presence of ETA and ETB receptors.
ETA Binding (presence) of
7) Confidence 0.35 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.22
Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors.
ETA Binding (interaction) of
8) Confidence 0.35 Published 2004 Journal Regul. Pept. Section Title Doc Link 14749038 Disease Relevance 0 Pain Relevance 0.20
Endothelins exert their effects by binding to two distinct cell surface ET receptors, ETA and ETB.
ETA Binding (binding) of
9) Confidence 0.31 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.28 Pain Relevance 0.08
Ligand binding to the endothelin receptor results in activation of a pertussis toxin-insensitive G protein that stimulates phospholipase C activity and increases intracellular Ca2+ levels, activation of protein kinase C, mitogen activated protein kinase (MAPK) and p125 focal adhesion kinase (FAK) phosphorylation.
endothelin receptor Binding (binding) of associated with kinase c, bordatella infection and adhesions
10) Confidence 0.31 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.57 Pain Relevance 0.08
Interestingly, the addition of a specific ETAR antagonist blocked the ET-1-induced resistance to paclitaxel-mediated apoptosis indicating that ET-1 contributes to trigger resistance to paclitaxel through ETAR binding via activation of anti-apoptotic signaling pathways such as Akt.
ETAR Binding (binding) of associated with antagonist and apoptosis
11) Confidence 0.31 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.14 Pain Relevance 0.17
Of note, ET-1 plasma levels correlate with parameters of pulmonary haemodynamics,12 and predict survival in patients with untreated PAH.13
ET Binding (correlate) of in plasma associated with pulmonary hypertension
12) Confidence 0.30 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.77 Pain Relevance 0.04
For example, there are more ET-1-binding sites in the distal pulmonary vessels of patients with PAH, and ETB receptors are also upregulated.24 ETB receptors may not exclusively mediate pulmonary vasodilatation.
ET Binding (binding) of in vessels associated with pulmonary hypertension and increased venous pressure under development
13) Confidence 0.29 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 1.00 Pain Relevance 0.07
Among various ETAR antagonists, ABT-627 (atrasentan, Abbott Laboratories, Abbott Park, IL) is an orally bioavailable endothelin antagonist that potently (Ki = 34 pM) and selectively binds to the ETAR, blocking signal transduction pathways implicated in cancer cell proliferation and other host-dependent processes promoting cancer growth (Figure 1).
ETAR Binding (binds) of associated with cancer and antagonist
14) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.27 Pain Relevance 0.36
In contrast, ETAR binds ET-1 with higher affinity than the other isoforms.
ETAR Binding (binds) of
15) Confidence 0.23 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.26 Pain Relevance 0.08
Engagement of the endothelin receptor by ET-1 induces tumor-promoting effects that are mediated by different downstream effectors, such as EGFR, VEGF COX-2, AKT, MAPK that could became the preferentially escaping pathways utilized by tumor cells.
endothelin receptor Binding (Engagement) of associated with cancer
16) Confidence 0.23 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.97 Pain Relevance 0.14
The peptide can trigger pain through ETAR of local nociceptors, and concurrently produces analgesia through ETBR by inducing the release of ?
ETAR Binding (trigger) of in nociceptors associated with pain, nociceptor and analgesia
17) Confidence 0.21 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.40 Pain Relevance 1.12
The initial 3,3-diphenyl propionic acid based ERAs from BASF/Knoll were discovered by screening of BASFÂ’s chemical library for compounds that bind to recombinant human ETA receptor.
ETA receptor Binding (bind) of associated with antagonist
18) Confidence 0.20 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.09 Pain Relevance 0.28
The peptide is synthesized by endothelial cells and either binds to the ETA receptor on smooth muscle cells to mediate vasoconstriction or binds to the ETB receptor on endothelial cells to mediate vasodilation via the autocrine release of NO, prostacyclin and by increasing removal of endothelin from the circulation.
ETA Binding (binds) of in smooth muscle cells associated with increased venous pressure under development
19) Confidence 0.19 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.47 Pain Relevance 0.06
Binding of (125)I-ET-1 to cell membranes of the muscularis mucosae was saturable and specific.
ET Binding (Binding) of
20) Confidence 0.16 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 11959373 Disease Relevance 0 Pain Relevance 0.25

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