INT5498

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 9.82
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
pituitary 4
locus coeruleus 4
frontal cortex 4
nucleus 2
urine 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 21 100.00 Very High Very High Very High
Hippocampus 18 100.00 Very High Very High Very High
amygdala 17 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
cva 12 99.96 Very High Very High Very High
Catecholamine 37 99.92 Very High Very High Very High
antinociception 3 99.80 Very High Very High Very High
Morphine 40 99.40 Very High Very High Very High
Dynorphin 8 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 155 100.00 Very High Very High Very High
Chronic Renal Failure 124 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 19 99.98 Very High Very High Very High
Hemorrhage 10 99.96 Very High Very High Very High
Urological Neuroanatomy 25 98.66 Very High Very High Very High
Appetite Loss 10 97.12 Very High Very High Very High
Inflammatory Pain 1 96.56 Very High Very High Very High
Pain 76 89.28 High High
Apoptosis 3 84.80 Quite High
Shock 4 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is hypothesized that stress-induced CRH activation is attenuated by the enhancement of the inhibitory GABAergic system activity associated with etifoxine.
Positive_regulation (induced) of Positive_regulation (activation) of CRH associated with stress and gabaergic
1) Confidence 0.70 Published 2004 Journal Physiol. Behav. Section Abstract Doc Link 15451655 Disease Relevance 1.10 Pain Relevance 0.14
In the frontal cortex, pretreatment with either SCH23390 or sulpiride did not alter the increases in the CRH mRNA levels induced by repeated 'binge' cocaine.
Neg (not) Positive_regulation (increases) of Positive_regulation (induced) of CRH mRNA in frontal cortex associated with urological neuroanatomy and cocaine
2) Confidence 0.66 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.23 Pain Relevance 0.62
Chronic morphine administration significantly increased the level of CRF mRNA 3, 24 and 48 h after the last dose.
Positive_regulation (increased) of Positive_regulation (increased) of CRF mRNA 3 associated with morphine
3) Confidence 0.50 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12747942 Disease Relevance 0.21 Pain Relevance 1.02
Although prednisolone resulted in a marked reduction of basal CRF mRNA, the stress-induced increment of CRF mRNA remained comparable with that found in untreated animals.
Positive_regulation (stress-induced) of Positive_regulation (increment) of CRF mRNA associated with stress
4) Confidence 0.50 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.33 Pain Relevance 0.11
These data suggest that neural signals, originating for cardiovascular receptors activated by hemorrhage, up-regulate message for CRH but not for AVP in the paraventricular nuclei of the rat hypothalamus.
Positive_regulation (up-regulate) of Positive_regulation (message) of CRH in neural associated with cva
5) Confidence 0.47 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311234 Disease Relevance 0.75 Pain Relevance 0.42
We evaluated the effect of general anesthetics on nitrous-oxide-induced CRF activation and antinociception.
Positive_regulation (induced) of Positive_regulation (activation) of CRF associated with antinociception
6) Confidence 0.47 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.36
The increase in immunocyte BE, therefore, seems to depend on the activation of CRH, catecholamines, and serotonin, but to be independent of activation of the hypothalamus-pituitary-adrenal-axis and prostaglandins.
Spec (seems) Positive_regulation (depend) of Positive_regulation (activation) of CRH in pituitary associated with catecholamine and serotonin
7) Confidence 0.46 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.12 Pain Relevance 0.42
Additionally, these rats showed increased response of the hypothalamic CRH mRNA to the lipopolysaccharide challenge.
Positive_regulation (increased) of Positive_regulation (response) of CRH mRNA
8) Confidence 0.46 Published 2007 Journal Endocrinology Section Abstract Doc Link 17347308 Disease Relevance 0.45 Pain Relevance 0.11
Adrenalectomy-induced enhancement of CRF and vasopressin immunoreactivity in parvocellular neurosecretory neurons: anatomic, peptide, and steroid specificity.
Positive_regulation (Adrenalectomy-induced) of Positive_regulation (enhancement) of CRF in neurosecretory neurons associated with neuropeptide
9) Confidence 0.45 Published 1987 Journal J. Neurosci. Section Title Doc Link 3553442 Disease Relevance 0 Pain Relevance 0.21
Stimulation of CRH neurones in the paraventricular nucleus also activates gamma-aminobenzoic acid and opioid neurones in the medial preoptic area and reduces GnRH cell recruitment, thereby decreasing GnRH pulse frequency.
Positive_regulation (activates) of Positive_regulation (Stimulation) of CRH in medial associated with urological neuroanatomy and opioid
10) Confidence 0.45 Published 2003 Journal Reproduction Section Abstract Doc Link 12578529 Disease Relevance 0.96 Pain Relevance 0.56
In the frontal cortex, pretreatment with either SCH23390 or sulpiride did not alter the increases in the CRH mRNA levels induced by repeated 'binge' cocaine.
Positive_regulation (induced) of Neg (not) Positive_regulation (increases) of CRH mRNA in frontal cortex associated with urological neuroanatomy and cocaine
11) Confidence 0.44 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.23 Pain Relevance 0.62
This upregulation of binding sites for the opioid-releasing agents corticotropin-releasing hormone and interleukin-1 beta likely represents part of the body's local response to combat inflammatory pain.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of corticotropin-releasing hormone in body associated with ipn and opioid
12) Confidence 0.43 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891603 Disease Relevance 0.24 Pain Relevance 0.93
Significant changes in corticotropin-releasing factor type 1 receptor messenger RNA levels were also observed in the paraventricular nucleus but with a slow incremental biosynthesis of the receptor messenger RNA, as high levels were discernible only 360 min after fluoxetine treatment.
Positive_regulation (observed) of Positive_regulation (changes) of corticotropin-releasing factor in nucleus associated with fluoxetine
13) Confidence 0.39 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740405 Disease Relevance 0.06 Pain Relevance 0.55
Severe stress also produces increased levels of CRF in the locus coeruleus, hippocampus and amygdala, increasing emotional lability [64].
Positive_regulation (increasing) of Positive_regulation (increased) of CRF in locus coeruleus associated with stress, locus ceruleus, hippocampus and amygdala
14) Confidence 0.32 Published 1999 Journal Crit Care Section Body Doc Link PMC137231 Disease Relevance 0.92 Pain Relevance 0.33
Urine output was significantly increased after induction of 5/6 nephrectomy in CRF rats (both CRF-V and CRF-C), whereas there was no change in urine output after sham operation in control rats (Fig. 2, Table 1).
Positive_regulation (increased) of Positive_regulation (induction) of CRF in urine associated with chronic renal failure
15) Confidence 0.30 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.21 Pain Relevance 0
While moderate increase of CRH output is important for stimulation of POMC transcription, the increase of the VP:CRH secretion ratio appears to be important in maintaining the secretory capacity of the pituitary corticotroph during chronic stimulation.
Positive_regulation (important) of Positive_regulation (increase) of CRH in pituitary
16) Confidence 0.23 Published 1994 Journal Front Neuroendocrinol Section Abstract Doc Link 7895891 Disease Relevance 0.66 Pain Relevance 0.07
Severe stress also produces increased levels of CRF in the locus coeruleus, hippocampus and amygdala, increasing emotional lability [64].
Positive_regulation (increasing) of in amygdala Positive_regulation (increased) of CRF in locus coeruleus associated with stress, locus ceruleus, hippocampus and amygdala
17) Confidence 0.11 Published 1999 Journal Crit Care Section Body Doc Link PMC137231 Disease Relevance 0.92 Pain Relevance 0.33
Severe stress also produces increased levels of CRF in the locus coeruleus, hippocampus and amygdala, increasing emotional lability [64].
Positive_regulation (increasing) of in hippocampus Positive_regulation (increased) of CRF in locus coeruleus associated with stress, locus ceruleus, hippocampus and amygdala
18) Confidence 0.11 Published 1999 Journal Crit Care Section Body Doc Link PMC137231 Disease Relevance 0.92 Pain Relevance 0.33
Finally, injection (icv) of 1.0 nmol beta-E or DYN blocked the nitroprusside-hypotension induced elevation of irCRF.
Positive_regulation (induced) of Positive_regulation (elevation) of irCRF associated with pressure volume 2 under development and dynorphin
19) Confidence 0.10 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 3031743 Disease Relevance 0.10 Pain Relevance 0.75
It has been shown that hard running and swimming exercise results in elevated levels of CRF in rats [57, 58] and increases in indirect markers of CRF in humans [59].
Positive_regulation (results) of Positive_regulation (elevated) of CRF
20) Confidence 0.09 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.40 Pain Relevance 0.08

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