INT54987

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.44
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
Plasma 2
neurons 2
lung 2
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 52 100.00 Very High Very High Very High
Neuropeptide 25 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
pruritus 59 99.48 Very High Very High Very High
qutenza 35 99.40 Very High Very High Very High
dorsal root ganglion 3 98.16 Very High Very High Very High
Opioid 8 92.48 High High
opioid receptor 10 92.20 High High
trigeminal ganglion 76 91.20 High High
Disease Link Frequency Relevance Heat
Pruritus 78 99.48 Very High Very High Very High
Nociception 17 99.38 Very High Very High Very High
Hypoxia 7 98.44 Very High Very High Very High
Ganglion Cysts 154 98.16 Very High Very High Very High
Sprains And Strains 16 94.20 High High
Increased Venous Pressure Under Development 1 88.04 High High
Targeted Disruption 63 77.92 Quite High
Hypertension 1 75.00 Quite High
Psoriasis 60 70.64 Quite High
Apoptosis 8 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following exposure to hypoxia, a subgroup of mice were treated with capsaicin, which did not significantly alter CGRP expression in the mouse lung.
Neg (not) Regulation (alter) of Gene_expression (expression) of CGRP in lung associated with qutenza, hypoxia and calcitonin gene-related peptide
1) Confidence 0.62 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12220736 Disease Relevance 0.66 Pain Relevance 0.49
These results suggest that: (1) early expression of the CGRP phenotype is regulated in a cell-autonomous way in developing mouse DRG neurons in vitro; and (2) the RTX-induced increase in CGRP biosynthesis is most likely the result of activating the capsaicin/RTX receptor rather than directly activating the protein kinase C (PKC) pathway in vitro.
Regulation (regulated) of Gene_expression (expression) of CGRP in neurons associated with dorsal root ganglion, kinase c, qutenza and calcitonin gene-related peptide
2) Confidence 0.62 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7955356 Disease Relevance 0.32 Pain Relevance 0.89
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Gene_expression (expression) of CGRP associated with calcitonin gene related peptide, neuropeptide and substance p
3) Confidence 0.18 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 1.11
Plasma levels of SP, CGRP, and VIP did not differ significantly
Neg (not) Regulation (differ) of Gene_expression (levels) of CGRP in Plasma associated with calcitonin gene-related peptide and substance p
4) Confidence 0.17 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.89 Pain Relevance 0.92
In addition, the proportion of different sensory populations, in particular those expressing CGRP, is unaltered.
Regulation (unaltered) of Gene_expression (expressing) of CGRP associated with calcitonin gene-related peptide
5) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.25
Another thermal nociception QTL, Tpnr2, localises to, and affects the expression of calcitonin gene-related peptide alpha (CGRP?)
Regulation (affects) of Gene_expression (expression) of calcitonin gene-related peptide alpha associated with nociception and calcitonin gene-related peptide
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.95 Pain Relevance 0.93

General Comments

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