INT5499

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Context Info
Confidence 0.72
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 52
Total Number 53
Disease Relevance 7.98
Pain Relevance 19.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
PVN 11
SCN 6
brain 4
hypothalamus 3
neurons 3
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 20 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
amygdala 11 99.84 Very High Very High Very High
withdrawal 48 99.76 Very High Very High Very High
corticosteroid 12 99.64 Very High Very High Very High
Morphine 23 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 38 100.00 Very High Very High Very High
Small Cell Lung Cancer 2 99.44 Very High Very High Very High
Nociception 16 99.38 Very High Very High Very High
Pressure Volume 2 Under Development 12 98.04 Very High Very High Very High
Hemorrhage 27 95.64 Very High Very High Very High
Cystitis 4 95.36 Very High Very High Very High
Body Weight 2 95.24 Very High Very High Very High
Cv Unclassified Under Development 1 94.24 High High
Pain 4 93.80 High High
Ganglion Cysts 8 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of arginine vasopressin (AVP) gene transcription in the paraventricular nucleus (PVN) was studied in rat hypothalamic organotypic cultures using intronic in situ hybridization.
Transcription (transcription) of arginine vasopressin in PVN
1) Confidence 0.72 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.08
The data demonstrate that cAMP directly activates AVP gene transcription in parvocellular neurons of the PVN.
Transcription (transcription) of AVP gene in PVN
2) Confidence 0.72 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.13
The regulation of arginine vasopressin (AVP) gene transcription in the paraventricular nucleus (PVN) was studied in rat hypothalamic organotypic cultures using intronic in situ hybridization.
Transcription (transcription) of AVP in PVN
3) Confidence 0.72 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.08
Direct stimulation of arginine vasopressin gene transcription by cAMP in parvocellular neurons of the paraventricular nucleus in organotypic cultures.
Transcription (transcription) of arginine vasopressin in neurons
4) Confidence 0.72 Published 2001 Journal Endocrinology Section Title Doc Link 11606471 Disease Relevance 0 Pain Relevance 0.10
These data indicate that dexamethasone could act on AVP cells independently of action potentials to decrease mRNA stability and to suppress AVP gene transcription during stimulation by cAMP.
Transcription (transcription) of AVP gene associated with action potential and dexamethasone
5) Confidence 0.72 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.62
AVP mRNA was also found in neurons of the suprachiasmatic nuclei, but there was no difference in the amount of mRNA between the 1-h hemorrhage and control groups.
Transcription (found) of AVP in neurons associated with cva
6) Confidence 0.72 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311234 Disease Relevance 0.82 Pain Relevance 0.49
Neuronal activity is required for the circadian rhythm of vasopressin gene transcription in the suprachiasmatic nucleus in vitro.
Transcription (transcription) of vasopressin in suprachiasmatic nucleus
7) Confidence 0.72 Published 2002 Journal Endocrinology Section Title Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.47
In contrast, the protein kinase C activator, phorbol 12-myristate 13-acetate, greatly increased AVP transcription in the absence of TTX, but this effect was blocked by TTX, indicating that the phorbol 12-myristate 13-acetate acted indirectly via synaptic input.
Transcription (transcription) of AVP associated with tetrodotoxin and kinase c
8) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.59
In contrast, the MAPK pathway inhibitor, PD98059, profoundly decreased AVP transcription and abolished its daily rhythm.
Transcription (transcription) of AVP
9) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.50
Inhibition of spontaneous activity by the sodium channel blocker, tetrodotoxin (TTX), dramatically decreased AVP heteronuclear RNA levels and suppressed rhythmicity, indicating that ongoing neural activity was required for the AVP gene transcription.
Transcription (transcription) of AVP gene in neural associated with tetrodotoxin and sodium channel
10) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.58
Neither protein kinase A nor protein kinase C pathways appear to be involved in the rhythmicity of AVP transcription in the SCN because selective inhibitors of these protein kinases were without effect.
Transcription (transcription) of AVP in SCN associated with kinase c
11) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.54
In the presence of TTX, the adenylate cyclase stimulator, forskolin, increased AVP transcription in the SCN.
Transcription (transcription) of AVP in SCN associated with tetrodotoxin
12) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.58
Transcription of the AVP gene in organotypic cultures of rat SCN was studied by using an intronic in situ hybridization.
Transcription (Transcription) of AVP gene in SCN
13) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.29
AVP gene transcription in the cultured SCN maintained a daily rhythm with a peak in the daytime.
Transcription (transcription) of AVP gene in SCN
14) Confidence 0.72 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.43
Basal vasopressin mRNA expression in the paraventricular and supraoptic nuclei decreased slightly 6 h after LPS injection, without changes in vasopressin transcription as indicated by vasopressin heteronuclear (hn) RNA levels.
Transcription (transcription) of vasopressin
15) Confidence 0.71 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535156 Disease Relevance 0.09 Pain Relevance 0.08
To examine this possibility, we compared the ability of THP, its precursor progesterone (P4), and the glucocorticoids dexamethasone (DEX) and corticosterone (CORT) to influence the pituitary-adrenal response to acute emotional stress and the adrenalectomy-induced increase in the gene transcription of the stress-related peptide arginine vasopressin (AVP) and of corticosteroid receptors (MR and GR) in the brain.
Transcription (transcription) of AVP in brain associated with stress, corticosteroid and dexamethasone
16) Confidence 0.69 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8946427 Disease Relevance 0.44 Pain Relevance 0.35
In addition, the expression of AVP heteronuclear (hn) RNA and neuronal nitric oxide synthase (nNOS) mRNA was also examined in the PVN of a CP-induced cystitis model.
Spec (examined) Transcription (expression) of AVP in neuronal associated with cystitis and neuronal nitric oxide synthase
17) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.26 Pain Relevance 0.05
Distribution of arginine-vasopressin in the trigeminal, dorsal root ganglia and spinal cord of the rat; depletion by capsaicin.
Transcription (Distribution) of arginine-vasopressin in dorsal root ganglia associated with qutenza and spinal cord
18) Confidence 0.69 Published 1995 Journal Comp. Biochem. Physiol. A Physiol. Section Title Doc Link 7866777 Disease Relevance 0.18 Pain Relevance 0.67
Relative to animals showing no significant levels of defensive burying activity, rats showing sustained elevations in defensive burying displayed higher levels of arginine vasopressin (AVP) mRNA and increased numbers of androgen receptor positive cells in the medial amygdala and posterior bed nuclei of the stria terminalis, brain regions that integrate emotional appraisal and sensory information.
Transcription (levels) of AVP in brain associated with amygdala
19) Confidence 0.69 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19540895 Disease Relevance 0.09 Pain Relevance 0.14
Relative to animals showing no significant levels of defensive burying activity, rats showing sustained elevations in defensive burying displayed higher levels of arginine vasopressin (AVP) mRNA and increased numbers of androgen receptor positive cells in the medial amygdala and posterior bed nuclei of the stria terminalis, brain regions that integrate emotional appraisal and sensory information.
Transcription (levels) of arginine vasopressin in brain associated with amygdala
20) Confidence 0.69 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19540895 Disease Relevance 0.09 Pain Relevance 0.14

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