INT54999

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.18
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3)
nucleus (Itpr3) transmembrane transport (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
myocytes 1
spinal cord 1
brain 1
Itpr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
electroacupuncture 24 99.82 Very High Very High Very High
Kappa opioid receptor 8 99.36 Very High Very High Very High
Spinal cord 12 99.04 Very High Very High Very High
Action potential 9 95.32 Very High Very High Very High
opioid receptor 1 93.96 High High
Dynorphin 1 91.36 High High
agonist 12 90.92 High High
analgesia 6 90.88 High High
tolerance 8 90.20 High High
tetrodotoxin 2 83.56 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 93.52 High High
Anaerobic Bacterial Infections 1 91.32 High High
Pain 44 50.00 Quite Low
Ganglion Cysts 20 48.00 Quite Low
Depression 1 13.36 Low Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High frequency electroacupuncture induced changes of IP3 level in rat brain and spinal cord.
Regulation (changes) of IP3 in brain associated with electroacupuncture and spinal cord
1) Confidence 0.24 Published 1994 Journal Chin. Med. J. Section Title Doc Link 7956484 Disease Relevance 0 Pain Relevance 1.04
Inositol phosphates carry out important regulatory functions, for example the regulation of IP3R channel activity.
Regulation (regulation) of IP3R
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.09 Pain Relevance 0.04
The responses of IP3 and [Ca2+]i to kappa-opioid receptor stimulation were abolished in myocytes of rats that had received chronic injection of U50,488H for 4 days. kappa-Opioid receptor stimulation with U50,488H also reduced the [Ca2+]i transient, induced by electrical stimulation and caffeine, both known to mobilize [Ca2+]i.
Regulation (responses) of IP3 in myocytes associated with kappa opioid receptor and opioid receptor
3) Confidence 0.16 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8836621 Disease Relevance 0 Pain Relevance 0.47
These results establish that the effect of the toxin on both intracellular Ca2+ and IP3 levels occurs via a membrane potential sensor instead of directly by Na+ flux and supports the notion of a train of action potentials being more efficient as a stimulus than sustained depolarization, suggesting that tetanus is the physiological stimulus for the IP3-dependent calcium signal involved in regulation of gene expression.
Regulation (effect) of IP3 associated with action potential and anaerobic bacterial infections
4) Confidence 0.13 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0.09 Pain Relevance 0.27
Furthermore, we report that the dADP is mediated by a nonselective cation channel current that is dependent on intracellular Ca2+ and IP3 receptor function, which suggests that the dADP is activated through a Gq/PLC coupled signaling pathway.
Regulation (dependent) of IP3 receptor
5) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.25
High frequency electroacupuncture induced changes of IP3 level in rat brain and spinal cord.
Regulation (changes) of IP3 in spinal cord associated with electroacupuncture and spinal cord
6) Confidence 0.08 Published 1994 Journal Chin. Med. J. Section Title Doc Link 7956484 Disease Relevance 0 Pain Relevance 1.04
The IP3R model also reproduced the fraction of open IP3R channels as a function of IP3 at a fixed calcium level (Fig. 3B).
Regulation (function) of IP3
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0

General Comments

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