INT5501

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Context Info
Confidence 0.62
First Reported 1974
Last Reported 2010
Negated 19
Speculated 70
Reported most in Abstract
Documents 283
Total Number 353
Disease Relevance 55.10
Pain Relevance 249.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 14
spinal cord 9
neurons 8
amygdala 6
blood 5
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1568 100.00 Very High Very High Very High
Opioid 1012 100.00 Very High Very High Very High
Morphine 815 100.00 Very High Very High Very High
narcan 561 100.00 Very High Very High Very High
agonist 510 100.00 Very High Very High Very High
antagonist 455 100.00 Very High Very High Very High
Enkephalin 338 100.00 Very High Very High Very High
amygdala 270 100.00 Very High Very High Very High
mu opioid receptor 200 100.00 Very High Very High Very High
Antinociceptive 192 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 46 100.00 Very High Very High Very High
Diabetes Mellitus 34 100.00 Very High Very High Very High
Drug Dependence 25 100.00 Very High Very High Very High
Eating Disorder 16 100.00 Very High Very High Very High
Convulsion 11 100.00 Very High Very High Very High
Nociception 110 99.84 Very High Very High Very High
Neuroblastoma 24 99.84 Very High Very High Very High
Targeted Disruption 11 99.84 Very High Very High Very High
Hemolysis 3 99.80 Very High Very High Very High
Overactive Bladder 5 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male Sprague-Dawley rats were utilized to study the effects of the opioid receptor antagonists, naloxone and naltrexone, on thirst induced by thermal dehydration.
Regulation (effects) of opioid receptor associated with antagonist, volume depletion and dehydration, narcan and opioid receptor
1) Confidence 0.62 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1475289 Disease Relevance 0.17 Pain Relevance 0.33
In the present study we have analyzed the regulation of delta-opioid receptor mRNA and the regulation of delta-opioid receptor activated astroglial Ca2+ responses in primary cultures from the rat cerebral cortex.
Spec (analyzed) Regulation (regulation) of delta-opioid receptor in cerebral cortex associated with opioid receptor and cerebral cortex
2) Confidence 0.62 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9302088 Disease Relevance 0 Pain Relevance 0.70
In the present study we have analyzed the regulation of delta-opioid receptor mRNA and the regulation of delta-opioid receptor activated astroglial Ca2+ responses in primary cultures from the rat cerebral cortex.
Spec (analyzed) Regulation (regulation) of delta-opioid receptor mRNA in cerebral cortex associated with opioid receptor and cerebral cortex
3) Confidence 0.62 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9302088 Disease Relevance 0 Pain Relevance 0.68
We have addressed the possibility that removal of maternal milk is the stimulus for the weaning-induced delta-receptor activation by studying the effect of lactating and nonlactating surrogate mothers and two milk substitutes (casein-rich and casein-free) on opioid receptor control of swim SIA.
Regulation (control) of opioid receptor associated with opioid receptor
4) Confidence 0.60 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181901 Disease Relevance 0.09 Pain Relevance 0.32
In the first series of experiments, the effects of PC, a nonselective opioid receptor antagonist (naloxone), and their combination on the infarct size after various durations of ischemia were assessed.
Regulation (effects) of opioid receptor associated with ischemia, antagonist, narcan and opioid receptor
5) Confidence 0.59 Published 1998 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 9825182 Disease Relevance 0.44 Pain Relevance 0.47
This indicates that the absence of G(z alpha) does not affect opioid receptor affinity or receptor up or down regulation.
Neg (not) Regulation (affect) of opioid receptor associated with opioid receptor
6) Confidence 0.59 Published 2000 Journal Brain Res. Section Abstract Doc Link 10869496 Disease Relevance 0 Pain Relevance 1.24
Regulation of opioid receptor activities.
Regulation (Regulation) of opioid receptor associated with opioid receptor
7) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10215631 Disease Relevance 0 Pain Relevance 0.67
With the availability of the cDNA clones of the mu-, delta- and kappa-opioid receptors, and the elucidation of their gene structures, it is now possible to investigate opioid receptor regulation at various levels, and to identify the specific receptors involved in the pharmacological actions of the opioids.
Spec (investigate) Regulation (regulation) of opioid receptor associated with kappa opioid receptor, opioid receptor and opioid
8) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215631 Disease Relevance 0 Pain Relevance 0.75
Summarized in this report are our past efforts in defining the regulation of opioid receptor activities.
Regulation (regulation) of opioid receptor associated with opioid receptor
9) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215631 Disease Relevance 0 Pain Relevance 0.75
The purpose of this study was to evaluate the effects of the gonadal hormones on the opioid receptor protein levels of Freund's adjuvant-treated (arthritic) male and female Lewis rats.
Regulation (effects) of opioid receptor protein in gonadal associated with opioid receptor and arthritis
10) Confidence 0.58 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18054782 Disease Relevance 0.47 Pain Relevance 0.32
However, the critical role of the endogenous glycolipid GM1 ganglioside in regulating Gs-coupled, excitatory opioid receptor functions has not been addressed in any of the recent reviews of opioid stimulatory mechanisms.
Regulation (regulating) of opioid receptor associated with opioid receptor and opioid
11) Confidence 0.58 Published 1998 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 9786023 Disease Relevance 0 Pain Relevance 0.69
Furthermore, our observation of an apparently specific reduction in opioid binding in these transfected cells suggests that they may provide a novel genetic approach for studying regulation of the opioid receptor in this defined cell line.
Regulation (regulation) of opioid receptor associated with opioid receptor and opioid
12) Confidence 0.54 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1313812 Disease Relevance 0.19 Pain Relevance 0.32
Moreover we have investigated whether a chronic treatment with the potent analogue D-Ala2-beta-CM-4-NH2 during the suckling period could affect mu and delta opioid receptor function.
Regulation (affect) of opioid receptor associated with opioid receptor
13) Confidence 0.54 Published 1986 Journal Brain Res. Section Abstract Doc Link 3022888 Disease Relevance 0 Pain Relevance 0.22
Though the mechanism(s) by which these peptides exert their physiological properties remain largely unknown, there is some indication that AOP's modulate opioid receptor levels.
Regulation (modulate) of opioid receptor associated with opioid receptor
14) Confidence 0.51 Published 1999 Journal Peptides Section Abstract Doc Link 10698116 Disease Relevance 0 Pain Relevance 0.59
At the transcriptional level, most recent studies have revealed both positive and negative roles for various transcription factors, vitamin A hormones and cytokines in opioid receptor gene regulation.
Regulation (regulation) of opioid receptor gene associated with opioid receptor and cytokine
15) Confidence 0.50 Published 2002 Journal Curr Opin Pharmacol Section Abstract Doc Link 11786311 Disease Relevance 0 Pain Relevance 0.34
Previous studies have shown GM1 ganglioside to play a crucial role in regulating excitatory opioid receptor function, which may underlie some aspects of opioid dependence, tolerance, and supersensitivity.
Regulation (regulating) of opioid receptor associated with addiction, tolerance, opioid receptor and opioid
16) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9073176 Disease Relevance 0.16 Pain Relevance 0.32
The effects of three opioid receptor agonists on the blood pressure and heart rate of anaesthetized normotensive, spontaneously hypertensive and renal hypertensive rats were measured. 2.
Regulation (effects) of opioid receptor in blood associated with hypertension, agonist and opioid receptor
17) Confidence 0.45 Published 1991 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1797445 Disease Relevance 0.83 Pain Relevance 0.25
The aims of the present study were to examine the effects of opioid receptor agonists and antagonists on the renal vascular (renal blood flow) and tubular (urinary sodium excretion) responses to renal nerve stimulation and norepinephrine in anesthetized spontaneously hypertensive rats (SHR).
Spec (examine) Regulation (effects) of opioid receptor in renal nerve associated with antagonist, hypertension, agonist and opioid receptor
18) Confidence 0.45 Published 1990 Journal Hypertension Section Abstract Doc Link 2351429 Disease Relevance 0.17 Pain Relevance 0.37
Effect of subtype-selective opioid receptor blockers on nitrous oxide antinociception in rats.
Regulation (Effect) of opioid receptor associated with antinociception, nociceptor and opioid receptor
19) Confidence 0.45 Published 1990 Journal Pharmacol. Res. Section Title Doc Link 2164191 Disease Relevance 0 Pain Relevance 0.92
Both social activity and opioid receptor occupancy were unaffected by morphine treatment in non-isolated rats.
Neg (unaffected) Regulation (unaffected) of opioid receptor associated with opioid receptor and morphine
20) Confidence 0.45 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 1.27

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