INT55013

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Context Info
Confidence 0.16
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
smooth muscle cells 1
platelet 1
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 92.68 High High
antagonist 19 76.52 Quite High
Inflammation 2 65.80 Quite High
fibrosis 4 29.28 Quite Low
anesthesia 1 25.00 Low Low
Bile 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 15 95.48 Very High Very High Very High
Pulmonary Hypertension 71 90.72 High High
Heart Rate Under Development 4 83.36 Quite High
Pressure And Volume Under Development 8 82.76 Quite High
INFLAMMATION 2 65.80 Quite High
Hyperplasia 1 61.88 Quite High
Hypertrophy 3 61.24 Quite High
Disease 19 58.92 Quite High
Fibrosis 5 29.28 Quite Low
Apoptosis 1 14.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the vasculature, ETA receptors are located on smooth muscle cells (SMCs) and fibroblasts, whereas ETB receptors are predominantly localized on endothelial cells and, to a lesser extent, on SMCs, fibroblasts, and macrophages.
Localization (localized) of ETB in smooth muscle cells
1) Confidence 0.16 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.71 Pain Relevance 0.03
The inhibition of platelet aggregation by IRL 1620 is due to an ETB receptor-mediated release of prostacyclin into the circulation, for it is inhibited by indomethacin, but not by FR 139317.
Localization (release) of ETB receptor in platelet
2) Confidence 0.06 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957593 Disease Relevance 0.27 Pain Relevance 0.15

General Comments

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