INT55014

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 16.61
Pain Relevance 9.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
Endothelial cell 4
smooth muscle cells 3
hypothalamus 2
MCA 2
brain 1
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 53 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
agonist 63 99.96 Very High Very High Very High
Cannabinoid 1 99.80 Very High Very High Very High
cva 67 99.72 Very High Very High Very High
Analgesic 19 99.56 Very High Very High Very High
tetrodotoxin 3 99.52 Very High Very High Very High
Neurotransmitter 2 99.40 Very High Very High Very High
Kinase C 261 99.36 Very High Very High Very High
menstrual migraine 1 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 48 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 78 99.90 Very High Very High Very High
Stroke 60 99.74 Very High Very High Very High
Cv General 4 Under Development 192 99.72 Very High Very High Very High
Pulmonary Hypertension 250 99.54 Very High Very High Very High
Middle Cerebral Artery Infarction 258 99.48 Very High Very High Very High
Diabetes Mellitus 29 99.38 Very High Very High Very High
Infarction 92 99.12 Very High Very High Very High
Menstral Migraine 1 99.12 Very High Very High Very High
Injury 22 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also induced genes related to pain, including 5-Hydroxytryptamine (serotonin) receptor 3a (Htr3a) and Endothelin receptor type B (Ednrb) in the hypothalamus, and increased the activity of superoxide dismutase in the hypothalamus, liver, and red blood cells.
Positive_regulation (induced) of Endothelin receptor type B in hypothalamus associated with pain and serotonin
1) Confidence 0.70 Published 2008 Journal Mol. Cells Section Abstract Doc Link 18413997 Disease Relevance 0.10 Pain Relevance 0.44
Stimulation of the neuronal ETB receptor produced a tetrodotoxin-sensitive increase in the intracellular calcium concentration in neurons which was followed by contraction of the neighboring smooth muscle cells.
Positive_regulation (Stimulation) of ETB receptor in smooth muscle cells associated with tetrodotoxin
2) Confidence 0.56 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8405366 Disease Relevance 0.09 Pain Relevance 0.10
Moreover, whether the decrease in cerebral infarct volume is due to PKC inhibition in the neuronal tissue or an effect of the attenuation of the ETB receptor upregulation in the arteries remains to be investigated.


Positive_regulation (upregulation) of ETB receptor in neuronal associated with kinase c and cv general 4 under development
3) Confidence 0.54 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.68 Pain Relevance 0.44
It also induced genes related to pain, including 5-Hydroxytryptamine (serotonin) receptor 3a (Htr3a) and Endothelin receptor type B (Ednrb) in the hypothalamus, and increased the activity of superoxide dismutase in the hypothalamus, liver, and red blood cells.
Positive_regulation (induced) of Ednrb in hypothalamus associated with pain and serotonin
4) Confidence 0.50 Published 2008 Journal Mol. Cells Section Abstract Doc Link 18413997 Disease Relevance 0.10 Pain Relevance 0.44
This is also seen in organ culture, where the upregulation of contractile ETB receptors in MCA is attenuated by both PKC inhibitors and ERK1/2 inhibitors [13,14,29].
Positive_regulation (upregulation) of ETB associated with kinase c
5) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.62 Pain Relevance 0.36
Treatment with the PKC inhibitor Ro-32-0432 reduces the upregulation of ETB receptors in the ipsilateral MCA 24 hours after transient middle cerebral artery occlusion.
Positive_regulation (upregulation) of ETB in middle cerebral artery associated with kinase c and middle cerebral artery infarction
6) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.65 Pain Relevance 0.41
In previous studies, we have demonstrated that in experimental ischemic stroke and subarachnoid hemorrhage (SAH) there is an upregulation of endothelin type B (ETB) receptors in the cerebral arteries [10,11].
Positive_regulation (upregulation) of ETB associated with cv general 4 under development, stroke and cva
7) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.86 Pain Relevance 0.42
The ETB receptors are normally situated on the endothelial cells, mediating dilatation, but in the case of SAH and experimental ischemic stroke there is an upregulation of contractile ETB receptors in the vascular smooth muscle cells [10,11].
Positive_regulation (upregulation) of ETB in smooth muscle cells associated with stroke and cva
8) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 1.03 Pain Relevance 0.44
The Ro-32-0432 treatment decreased the ETB receptor upregulation, as well as diminished the ischemic infarct area and improved the neurological status of the animals.
Positive_regulation (upregulation) of ETB receptor
9) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.89 Pain Relevance 0.21
Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat

Background

Positive_regulation (upregulation) of ETB receptor in brain associated with kinase c, cv general 4 under development and ischemia
10) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Title Doc Link PMC1770924 Disease Relevance 0.52 Pain Relevance 0.28
Furthermore, the contractile ETB receptor upregulation seen in the ipsilateral MCA of the control animals is attenuated by the Ro-32-0432 treatment.
Positive_regulation (upregulation) of ETB receptor
11) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.59 Pain Relevance 0.38
The results suggest that treatment with Ro-32-0432 in ischemic stroke decreases the ischemic infarction area, neurological symptoms and associated endothelin B receptor upregulation.
Positive_regulation (upregulation) of endothelin B receptor associated with stroke and infarction
12) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1770924 Disease Relevance 0.59 Pain Relevance 0.13
The aim of the present study was to examine if a general PKC inhibitor, Ro-32-0432, can decrease the ETB receptor upregulation in MCA and reduce the ischemic infarct volume after experimental ischemic stroke.
Positive_regulation (upregulation) of ETB receptor associated with kinase c and stroke
13) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.94 Pain Relevance 0.31
In diabetes, ET-1 levels are elevated and upregulation of ETA and ETB occurs in the vasculature, along with a reduction in NO bioavailability.1,4 Activated ET receptors can also be found in diabetic complications such as cardiomyopathy and testopathy.24–26 NOX is stimulated mainly by ETA, with PKC actively involved.27 The vasoconstrictive activity of ET-1 is mediated by the activity of NOX, and an activation of the L-type calcium channels by ET-1 causes an influx of calcium ions through activating NOX.28 An interaction of ET-1 with ROS is known as the ET–ROS pathway, which activates the ERK signaling pathway and AP-1 transcriptional factor.29 There is a positive feedback mechanism between them via an activation of ERK.
Positive_regulation (upregulation) of ETB in vasculature associated with kinase c, diabetes complications, diabetes mellitus, calcium channel, coronary heart disease and bioavailability
14) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.09 Pain Relevance 0.14
The genes that were upregulated included synapsin-2, endothelin receptor type B, activity and neurotransmitter-induced early gene 7 (ania-7), phosphoserine aminotransferase, MHC-1b, and ERK-1.
Positive_regulation (upregulated) of endothelin receptor type B associated with neurotransmitter
15) Confidence 0.28 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396664 Disease Relevance 0.31 Pain Relevance 0.44
Endothelin 1 (ET-1) acts on ETA and ETB receptors to promote mitosis of pulmonary artery smooth muscle cells; activation of ETA and ETB on smooth muscle cells causes vasoconstriction, whereas activation of ETB on the endothelial cell releasing NO causes vasodilatation.
Positive_regulation (activation) of ETB in endothelial cell associated with increased venous pressure under development
16) Confidence 0.25 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.92 Pain Relevance 0.16
In summary, i.c.v. injections of ET-1 increased sympathetic nerve activity and blood pressure via ET-A receptors but not via ET-B receptors.
Neg (not) Positive_regulation (increased) of ET-B in sympathetic
17) Confidence 0.23 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10367590 Disease Relevance 0.10 Pain Relevance 0.24
The release of tachykinins and endothelin-3 (ET-3) from trigeminal neurons induces dural vascular permeability and vasodilatation via activation of tachykinin receptor 1 (Tacr1) and endothelin receptor type B (Ednrb) on endothelial cells.
Positive_regulation (activation) of endothelin receptor type B in endothelial cells associated with increased venous pressure under development
18) Confidence 0.21 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 16249526 Disease Relevance 0.90 Pain Relevance 0.40
We have observed a rapid transcriptional upregulation of contractile endothelin-1 (ETB receptors), and angiotensin II AT1 receptors in vascular smooth muscle cells in the middle cerebral artery (MCA) leading to the ischemic region starting immediately after induction of the cerebral ischemia [6,7].
Positive_regulation (upregulation) of ETB in MCA associated with cv general 4 under development and ischemia
19) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.67 Pain Relevance 0.25
The Western blot experiments showed a significant increase in ETB protein level after MCAO as compare to the vehicle group (122 ± 9 %; p < 0.05).
Positive_regulation (increase) of ETB protein associated with middle cerebral artery infarction
20) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.31 Pain Relevance 0.04

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