INT5502

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 69
Total Number 78
Disease Relevance 43.06
Pain Relevance 42.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
PVN 28
neurons 14
descending colon 12
locus coeruleus 12
visceral 11
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 489 100.00 Very High Very High Very High
Pain 378 100.00 Very High Very High Very High
Visceral pain 76 100.00 Very High Very High Very High
Serotonin 69 100.00 Very High Very High Very High
Locus ceruleus 67 100.00 Very High Very High Very High
Hippocampus 65 100.00 Very High Very High Very High
Enkephalin 55 100.00 Very High Very High Very High
Dynorphin 21 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
electroacupuncture 281 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 714 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

76 100.00 Very High Very High Very High
Hypoglycemia 14 100.00 Very High Very High Very High
Injury 88 99.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1552 99.84 Very High Very High Very High
Morphine Dependence 14 99.48 Very High Very High Very High
Hyperalgesia 65 99.38 Very High Very High Very High
INFLAMMATION 177 99.36 Very High Very High Very High
Cystitis 8 98.96 Very High Very High Very High
Unconsciousness 32 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose a specific role for down-regulation of opiate receptor signaling in increased expression of the CRH gene in the amygdala.
Positive_regulation (increased) of Gene_expression (expression) of CRH gene in amygdala associated with opiate and amygdala
1) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 12074902 Disease Relevance 0.23 Pain Relevance 1.37
Our findings of an increase in amygdalar CRH gene expression during early cocaine withdrawal support a potentially important role for amygdalar CRH activity in the anxiogenic and aversive consequences of withdrawal from cocaine during a time when humans are most subject to relapse.
Positive_regulation (increase) of Gene_expression (expression) of CRH associated with withdrawal, recurrence and cocaine
2) Confidence 0.70 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.30 Pain Relevance 1.05
Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus.
Positive_regulation (induced) of Gene_expression (expression) of CRH mRNA in hypothalamus associated with corticosteroid and agonist
3) Confidence 0.69 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0 Pain Relevance 0.48
Results indicate that TOT deafferentations resulted in significant increases in CRH mRNA expression in the PVN, and a slight but noticeable induction of AVP mRNA in the medial parvocellular but not posterior magnocellular divisions of the PVN.
Positive_regulation (increases) of Gene_expression (expression) of CRH mRNA in PVN
4) Confidence 0.68 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0
The data indicate that in the absence of neuronal input coming from anterior structures, CRH mRNA expression is up-regulated, suggesting that local effects of glucocorticoids on the PVN neuron are ineffective in maintaining normal CRH mRNA expression.
Positive_regulation (up-regulated) of Gene_expression (expression) of CRH mRNA in neuron
5) Confidence 0.68 Published 1990 Journal Endocrinology Section Abstract Doc Link 2171915 Disease Relevance 0 Pain Relevance 0
Upregulation of corticotropin-releasing hormone gene expression in the paraventricular nucleus of cyclophosphamide-induced cystitis in male rats.
Positive_regulation (Upregulation) of Gene_expression (expression) of corticotropin-releasing hormone in nucleus associated with nociceptor and cystitis
6) Confidence 0.68 Published 2004 Journal Brain Res. Section Title Doc Link 15276878 Disease Relevance 0.38 Pain Relevance 0.34
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (expression) of CRF in PVN associated with addiction, withdrawal and morphine
7) Confidence 0.66 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.45 Pain Relevance 1.14
Previous animal studies have suggested that exposures to psychological and physiological stresses immediately increase CRF expression in the CeA (29, 30).
Positive_regulation (increase) of Gene_expression (expression) of CRF associated with stress and amygdala
8) Confidence 0.63 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.67 Pain Relevance 0.82
Our results also indicate a sustained increased expression of CRF in the amygdala at 72 hr after CRD.
Positive_regulation (increased) of Gene_expression (expression) of CRF in amygdala associated with amygdala
9) Confidence 0.63 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.68 Pain Relevance 0.79
We observed (1) increases in pulp CRF-R immunoreactivity after injury, (2) increased CRF-R immunoreactivity expressed in 3 distinct zones in relation to the injury, and (3) increased CD45 and END immunoreactivity in regions surrounding the pulpal abscess.
Positive_regulation (increased) of Gene_expression (expressed) of CRF associated with injury and abscess
10) Confidence 0.63 Published 2007 Journal J Endod Section Abstract Doc Link 17963955 Disease Relevance 0.45 Pain Relevance 0.29
This conclusion is based on our finding that intravenous injection of IL-1 increases CRF biosynthesis in the PVN, and that lesion of this hypothalamic area interferes with IL-1's stimulatory action on ACTH secretion.
Positive_regulation (increases) of Gene_expression (biosynthesis) of CRF in PVN
11) Confidence 0.63 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.17
Psychological stress induces CRH gene expression in the amygdala (Makino et al. [49]), antagonism of CRH receptors in the CeA reduces freezing induced by foot shocks

(Diamant et al. [50]) and icv CRH administration promotes freezing and reduces shock-probe burying (Swiergiel et al. [51]).

Positive_regulation (induces) of Gene_expression (expression) of CRH in foot associated with stress, shock and amygdala
12) Confidence 0.61 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.44 Pain Relevance 0.56
A marked increase in steady-state levels of CRH gene expression in the hypothalamic paraventricular nucleus (PVN) was detected after icv PACAP injection, which was blocked by coadministration of a selective PACAP receptor antagonist (Grinevich et al. [6]).
Positive_regulation (increase) of Gene_expression (expression) of CRH in nucleus associated with antagonist
13) Confidence 0.61 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.28 Pain Relevance 0.16
These results suggest that 1) central administration of EP acts through the opioid receptor to inhibit hypoglycemia-induced CRF gene expression in the hypothalamus and CRF release, which results in a decrease in ACTH secretion and POMC mRNA levels in the AP; and 2) the active site of EP is the CRF neuron in the paraventricular nucleus.
Positive_regulation (induced) of Gene_expression (expression) of CRF gene in hypothalamus associated with hypoglycemia and opioid receptor
14) Confidence 0.52 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.43 Pain Relevance 0.16
Forskolin-stimulated CRH mRNA levels in the paraventricular nucleus were also inhibited by CORT or DEX in the presence and in the absence of TTX.
Positive_regulation (stimulated) of Gene_expression (levels) of CRH mRNA in nucleus associated with dexamethasone
15) Confidence 0.50 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.06 Pain Relevance 0.55
Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 +/- 2.54 vs 25.17 +/- 4.63; plasma CRF: 11.82 +/- 2.54 ng/L vs 25.17 +/- 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased significantly (fluorescence intensity of duodenal VIP: 67.37 +/- 18.90 vs 44.51 +/- 16.37; plasma VIP: 67.37 +/- 18.90 ng/L vs 44.51 +/- 16.37 ng/L, P < 0.01).
Positive_regulation (duodenal) of Gene_expression (expression) of CRF in plasma
16) Confidence 0.50 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.13 Pain Relevance 0
Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 +/- 2.54 vs 25.17 +/- 4.63; plasma CRF: 11.82 +/- 2.54 ng/L vs 25.17 +/- 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased significantly (fluorescence intensity of duodenal VIP: 67.37 +/- 18.90 vs 44.51 +/- 16.37; plasma VIP: 67.37 +/- 18.90 ng/L vs 44.51 +/- 16.37 ng/L, P < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of CRF in plasma
17) Confidence 0.50 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.13 Pain Relevance 0
In late pregnancy, inhibition of 5alpha-reductase (an allopregnanolone-synthesizing enzyme) with finasteride restored HPA axis responses (rapidly increased pPVN CRH mRNA expression, ACTH, and corticosterone secretion) to IL-1beta.
Positive_regulation (increased) of Gene_expression (expression) of pPVN CRH mRNA
18) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19458216 Disease Relevance 0.22 Pain Relevance 0.50
This PPT elevation was not influenced by i.v. injection of alpha-helical CRF or IL-1ra.
Positive_regulation (injection) of Gene_expression (injection) of CRF
19) Confidence 0.49 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15315264 Disease Relevance 0.47 Pain Relevance 1.23
Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression.
Positive_regulation (stimulation) of Gene_expression (expression) of corticotropin-releasing hormone
20) Confidence 0.49 Published 2002 Journal J. Neuroendocrinol. Section Title Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.34

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