INT5503

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 16.82
Pain Relevance 21.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 12
PVN 10
amygdala 10
MCG 4
Kidney 4
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 196 100.00 Very High Very High Very High
amygdala 95 100.00 Very High Very High Very High
antagonist 48 100.00 Very High Very High Very High
Analgesic 18 100.00 Very High Very High Very High
opiate 18 100.00 Very High Very High Very High
dexamethasone 13 100.00 Very High Very High Very High
cocaine 12 100.00 Very High Very High Very High
Visceral pain 23 99.98 Very High Very High Very High
fluoxetine 19 99.98 Very High Very High Very High
opioid receptor 95 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 248 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

242 100.00 Very High Very High Very High
Lordosis 24 100.00 Very High Very High Very High
Hypoglycemia 13 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

23 99.98 Very High Very High Very High
Urological Neuroanatomy 45 99.92 Very High Very High Very High
Thyroid Disease 3 99.46 Very High Very High Very High
Ulcers 3 99.28 Very High Very High Very High
INFLAMMATION 172 99.00 Very High Very High Very High
Opiate Addiction 3 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, in rats chronically treated with morphine, the intensity of labelling for CRF mRNA was significantly reduced, suggesting a decrease in the synthesis of CRF.
Negative_regulation (decrease) of Gene_expression (synthesis) of CRF associated with morphine
1) Confidence 0.59 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.90
CORT (500 nm) or DEX (50 nm) treatment for 24 h significantly inhibited CRH expression in the parvocellular neurones and this effect of corticosteroids was not affected following blockade of voltage dependent sodium channels by TTX.
Negative_regulation (inhibited) of Gene_expression (expression) of CRH associated with corticosteroid, sodium channel and dexamethasone
2) Confidence 0.59 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.06 Pain Relevance 0.54
In addition, rats pretreated with R121919 prior to precipitation of morphine withdrawal demonstrated decreased hypothalamic-pituitary-adrenal axis activation, as measured by plasma ACTH concentrations, and decreased early expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA.
Negative_regulation (decreased) of Gene_expression (expression) of CRF gene in hypothalamus associated with withdrawal and morphine
3) Confidence 0.57 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610870 Disease Relevance 0.39 Pain Relevance 0.89
However, elevated plasma ACTH levels and CRF levels in the median eminence were decreased by central administration of alpha MSH in adrenalectomized rats.
Negative_regulation (decreased) of Gene_expression (levels) of CRF in median eminence
4) Confidence 0.55 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970145 Disease Relevance 0 Pain Relevance 0.10
In conclusion, suppression of cortical activation by general anesthesia during visceral pain attenuated the expression of CRF in the CeA, suggesting that the conscious recognition of pain at a cortical level is an important determinant of the involvement of CRF in the mechanisms of subcortical pain control.



Negative_regulation (attenuated) of Gene_expression (expression) of CRF in visceral associated with pain, visceral pain, anesthesia and amygdala
5) Confidence 0.53 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.73 Pain Relevance 0.82
We speculate that the decreased CRF expression in the CeA of anesthetized rats is related to the reduction of cortical activity caused by general anesthesia, which disrupts the relay of pain-related information from the neocortex to the amygdala.
Negative_regulation (decreased) of Gene_expression (expression) of CRF in amygdala associated with pain, anesthesia and amygdala
6) Confidence 0.53 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.38 Pain Relevance 1.16
We propose a specific role for down-regulation of opiate receptor signaling in increased expression of the CRH gene in the amygdala.
Negative_regulation (regulation) of Gene_expression (expression) of CRH gene in amygdala associated with opiate and amygdala
7) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 12074902 Disease Relevance 0.24 Pain Relevance 1.39
We propose a specific role for down-regulation of opiate receptor signaling in increased expression of the CRH gene in the amygdala.
Negative_regulation (down) of Gene_expression (expression) of CRH gene in amygdala associated with opiate and amygdala
8) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 12074902 Disease Relevance 0.24 Pain Relevance 1.39
Type II corticosteroid receptor agonists act directly on paraventricular neurones to inhibit basal and forskolin-induced CRH mRNA expression in explant cultures of the rat hypothalamus.
Negative_regulation (inhibit) of Gene_expression (expression) of CRH mRNA in hypothalamus associated with corticosteroid and agonist
9) Confidence 0.43 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0 Pain Relevance 0.49
Fluoxetine improved depressed behavior, increased VIP expression and decreased CRF expression in plasma and the duodenal tissue of depressed rats.
Negative_regulation (decreased) of Gene_expression (expression) of CRF in plasma
10) Confidence 0.43 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0 Pain Relevance 0
In parallel with the decrease in the expression of CRF and AVP mRNAs in the PVN, there was a pronounced decrease in noradrenaline turnover and in the release of corticosterone in the morphine-pelleted rats.
Negative_regulation (decrease) of Gene_expression (expression) of CRF in PVN associated with noradrenaline and morphine
11) Confidence 0.43 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.95
In conclusion, present results show that, in addition to modifications in corticosterone secretion and in noradrenaline turnover, chronic morphine administration produces a reduction in the synthesis of CRF and AVP.
Negative_regulation (reduction) of Gene_expression (synthesis) of CRF associated with noradrenaline and morphine
12) Confidence 0.43 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.74
Studies were designed to investigate whether blocking CRF-1 receptors with selective antagonists or reducing their expression with CRF-Saporin, would attenuate ulcer, inflammatory- and neuropathic-like pain.
Spec (whether) Negative_regulation (reducing) of Gene_expression (expression) of CRF-Saporin associated with pain, inflammation, antagonist, neuropathic pain and ulcers
13) Confidence 0.43 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20470804 Disease Relevance 1.03 Pain Relevance 0.79
Forskolin-stimulated CRH mRNA levels in the paraventricular nucleus were also inhibited by CORT or DEX in the presence and in the absence of TTX.
Negative_regulation (absence) of Gene_expression (levels) of CRH mRNA in nucleus associated with dexamethasone
14) Confidence 0.43 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 18624927 Disease Relevance 0.06 Pain Relevance 0.56
A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis.
Negative_regulation (decreases) of Gene_expression (expression) of corticotropin releasing hormone in amygdala associated with dopamine, enkephalin and amygdala
15) Confidence 0.42 Published 2002 Journal Brain Res. Section Title Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.51
Increased neuronal 5-HT content induced by systemic administration of the precursor 5-hydroxytryptophan (5-HTP) in combination with the 5-HT reuptake inhibitor fluoxetine raised CRH mRNA expression in the paraventricular nucleus (PVN) by 64%, increased pro-opiomelanocortin (POMC) mRNA in the anterior pituitary lobe by 17% and stimulated ACTH secretion five-fold.
Negative_regulation (raised) of Gene_expression (expression) of CRH mRNA in lobe associated with fluoxetine
16) Confidence 0.42 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.36
RESULTS: Pretreatment with R121919 attenuated the subsequent HPA axis activation, behavioral measures of anxiety, and expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam.
Negative_regulation (attenuated) of Gene_expression (expression) of CRF gene in hypothalamus
17) Confidence 0.42 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17297634 Disease Relevance 0.08 Pain Relevance 0
These findings suggest that the inhibitory effect of repeated 'binge' cocaine on the hypothalamic CRH mRNA expression is absent when there is D(1), but not D(2), dopamine receptor blockade.
Negative_regulation (effect) of Neg (absent) Gene_expression (expression) of CRH mRNA associated with dopamine receptor and cocaine
18) Confidence 0.41 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.25 Pain Relevance 0.71
In contrast, no expression of CRF(2) transcripts was observed in the PVN either in basal conditions or after AA i.p.
Negative_regulation (observed) of Gene_expression (expression) of CRF in PVN
19) Confidence 0.41 Published 2004 Journal Pain Section Abstract Doc Link 15288415 Disease Relevance 0.08 Pain Relevance 0.47
An antisense oligonucleotide directed against the CRF(2) receptor mRNA reduced expression of CRF(2) receptors by 60--80%.
Negative_regulation (reduced) of Gene_expression (expression) of CRF
20) Confidence 0.41 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11311973 Disease Relevance 0.49 Pain Relevance 0.20

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