INT55033

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Context Info
Confidence 0.80
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.40
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3) cellular_component (Edn3)
Anatomy Link Frequency
sympathetic 2
endothelial cells 1
Edn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 43 100.00 Very High Very High Very High
tetrodotoxin 12 99.92 Very High Very High Very High
substance P 16 99.78 Very High Very High Very High
Inflammation 35 99.72 Very High Very High Very High
nMDA receptor 3 97.56 Very High Very High Very High
antagonist 42 96.48 Very High Very High Very High
intrathecal 2 94.96 High High
cva 2 94.76 High High
Spinal cord 2 94.44 High High
Migraine 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 8 99.72 Very High Very High Very High
Pressure Volume 2 Under Development 7 97.52 Very High Very High Very High
Increased Venous Pressure Under Development 7 97.12 Very High Very High Very High
Hemorrhage 2 94.76 High High
Headache 5 75.00 Quite High
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that sympathetic activation enhances endothelin-3 release but that nitroprusside may act directly to suppress release.
Localization (release) of endothelin-3 in sympathetic
1) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982458 Disease Relevance 0.37 Pain Relevance 0.13
The present study was designed to identify whether endothelin-3 is released upon changes in sympathetic nervous activity.
Localization (released) of endothelin-3 in sympathetic
2) Confidence 0.80 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7982458 Disease Relevance 0.33 Pain Relevance 0.14
Endothelin-3-evoked dopamine release was attenuated by D-2-amino-5-phosphnovaleric acid or Mg2+, N-methyl-D-aspartate receptor inhibitors, and this attenuation was not observed in the presence of tetrodotoxin, thereby indicating that the tetrodotoxin-sensitive component of dopamine release was partially mediated by glutamatergic pathways.
Localization (release) of Endothelin-3 associated with tetrodotoxin, dopamine and nmda receptor
3) Confidence 0.70 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957613 Disease Relevance 0 Pain Relevance 0.92
Two distinct pathways are involved in the endothelin-3-evoked dopamine release from rat striatal slices.
Localization (release) of endothelin-3 associated with dopamine
4) Confidence 0.70 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7957613 Disease Relevance 0 Pain Relevance 0.88
We investigated mechanisms mediating endothelin-3-evoked dopamine release from rat striatal slices.
Localization (release) of endothelin-3 associated with dopamine
5) Confidence 0.61 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957613 Disease Relevance 0 Pain Relevance 0.58
ETs release Substance P (406) and ET-3 release is augmented by IGF-I and inhibited by TGF-?
Localization (release) of ET-3 associated with substance p
6) Confidence 0.25 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.11
The release of tachykinins and endothelin-3 (ET-3) from trigeminal neurons induces dural vascular permeability and vasodilatation via activation of tachykinin receptor 1 (Tacr1) and endothelin receptor type B (Ednrb) on endothelial cells.
Localization (release) of endothelin-3 in endothelial cells associated with increased venous pressure under development
7) Confidence 0.04 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 16249526 Disease Relevance 0.69 Pain Relevance 0.31

General Comments

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