INT55034

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 14.10
Pain Relevance 6.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) aging (Adm) extracellular region (Adm)
response to stress (Adm) cytoplasm (Adm)
Anatomy Link Frequency
plasma 6
blood 2
ventricles 1
margin 1
spinal cord 1
Adm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 29 100.00 Very High Very High Very High
Dorsal horn 2 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
Kinase C 5 99.78 Very High Very High Very High
Pain 23 99.68 Very High Very High Very High
Spinal cord 7 99.68 Very High Very High Very High
Calcitonin gene-related peptide 20 99.56 Very High Very High Very High
anesthesia 23 99.24 Very High Very High Very High
cOX1 5 99.24 Very High Very High Very High
COX2 5 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 320 100.00 Very High Very High Very High
Hypoxia 148 100.00 Very High Very High Very High
Natriuresis 33 100.00 Very High Very High Very High
Sepsis 25 99.84 Very High Very High Very High
Pain 17 99.68 Very High Very High Very High
Pneumonia 26 99.40 Very High Very High Very High
Hypertension 30 99.28 Very High Very High Very High
Systemic Sclerosis 29 99.28 Very High Very High Very High
Porphyria 2 98.88 Very High Very High Very High
Death 17 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats.
Positive_regulation (Upregulation) of adrenomedullin in spinal cord associated with inflammation and spinal cord
1) Confidence 0.61 Published 2009 Journal Pain Section Title Doc Link 19683388 Disease Relevance 0.65 Pain Relevance 0.82
Adrenomedullin (ADM) is upregulated in cardiac tissue under various pathophysiological conditions.
Positive_regulation (upregulated) of Adrenomedullin
2) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.07 Pain Relevance 0.03
Adrenomedullin (ADM) is upregulated in cardiac tissue under various pathophysiological conditions.
Positive_regulation (upregulated) of ADM
3) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.07 Pain Relevance 0.03
Adrenomedullin (ADM), a peptide with potent vasodilatory and natriuretic actions, is elevated in patients with essential hypertension.
Positive_regulation (elevated) of ADM associated with natriuresis and hypertension
4) Confidence 0.60 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.70 Pain Relevance 0
ADM infusion elevated (P<.05) plasma ADM levels in ADM-infused SHR (679+/-47 pg/mL in ADM-50, 858+/-79 in ADM-100) compared with control (79.5+/-27.8).
Positive_regulation (elevated) of ADM in plasma
5) Confidence 0.60 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.60 Pain Relevance 0
Adrenomedullin (ADM), a peptide with potent vasodilatory and natriuretic actions, is elevated in patients with essential hypertension.
Positive_regulation (elevated) of Adrenomedullin associated with natriuresis and hypertension
6) Confidence 0.60 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.70 Pain Relevance 0
These findings demonstrate that plasma-mature adrenomedullin concentration increased and that increased plasma-mature adrenomedullin is associated with increased blood volume during pregnancy.
Positive_regulation (increased) of adrenomedullin in blood
7) Confidence 0.58 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16301265 Disease Relevance 0.10 Pain Relevance 0.06
A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats.
Positive_regulation (upregulation) of adrenomedullin associated with kinase c, tolerance and morphine
8) Confidence 0.56 Published 2010 Journal J. Neurosci. Section Title Doc Link 20844145 Disease Relevance 0.38 Pain Relevance 1.32
The present data demonstrate that the entire adrenomedullin molecule is not required for full systemic vasodilator activity in vivo suggesting that rat adrenomedullin-(11-50) or a structurally similar peptide, if formed endogenously, could mediate the hemodynamic properties of adrenomedullin in vivo.
Neg (not) Positive_regulation (required) of adrenomedullin
9) Confidence 0.50 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957618 Disease Relevance 0 Pain Relevance 0
Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis?
Positive_regulation (effects) of adrenomedullin associated with anesthesia and sepsis
10) Confidence 0.44 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 14766677 Disease Relevance 0.22 Pain Relevance 0.31
At 4 h after LPS injection, ADM levels markedly increased in plasma, ventricles, and freshly isolated ventricular myocytes.
Positive_regulation (increased) of ADM in plasma
11) Confidence 0.41 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.26 Pain Relevance 0.12
However, it is unclear whether elevation of plasma ADM within the pathophysiological range has similar actions.
Spec (whether) Positive_regulation (elevation) of ADM in plasma
12) Confidence 0.41 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.78 Pain Relevance 0
Thus, acute increases in ADM to levels found in pathophysiological conditions have no effect on blood pressure, pressure natriuresis, or renal autoregulation in the SHR.
Positive_regulation (increases) of ADM in blood associated with natriuresis
13) Confidence 0.41 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.30 Pain Relevance 0
ADM infusion elevated (P<.05) plasma ADM levels in ADM-infused SHR (679+/-47 pg/mL in ADM-50, 858+/-79 in ADM-100) compared with control (79.5+/-27.8).
Positive_regulation (elevated) of ADM in plasma
14) Confidence 0.41 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.61 Pain Relevance 0
Under constant force contraction, amplitude of surface EMG signal decreased in BIC and increased in ADM during pain with respect to control condition.
Positive_regulation (increased) of ADM in ADM associated with pain
15) Confidence 0.40 Published 2007 Journal Brain Res. Section Abstract Doc Link 17134682 Disease Relevance 0.57 Pain Relevance 0.49
We also demonstrated that a CGRP superfamily peptide, adrenomedullin, is distributed in perivascular nerves of rat mesenteric resistance arteries.
Positive_regulation (distributed) of adrenomedullin in nerves associated with calcitonin gene-related peptide
16) Confidence 0.38 Published 2007 Journal Neuroscience Section Abstract Doc Link 17101235 Disease Relevance 0 Pain Relevance 0.36
An increase in the activities of ADM in the short and median term application of clonidine and of 7-ERO-D in the long term application was detected.
Positive_regulation (increase) of ADM associated with clonidine
17) Confidence 0.30 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8141818 Disease Relevance 0.27 Pain Relevance 0.43
Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats.
Positive_regulation (Upregulation) of adrenomedullin in dorsal root ganglia associated with inflammation and spinal cord
18) Confidence 0.21 Published 2009 Journal Pain Section Title Doc Link 19683388 Disease Relevance 0.65 Pain Relevance 0.82
The replacement of the 4-methanesulfonyl benzoyl moiety in AP82 with the pyridine template, 3,5-dimethyl-4-methoxy-2-pyridyl function, gave rise to AP84, which was less active in the acute model, but gave 54% and 75% protection both during the first day and fifth day, respectively, in the chronic model.
Positive_regulation (active) of AP84
19) Confidence 0.17 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12535659 Disease Relevance 0.70 Pain Relevance 0.34
Following axotomy, AP and NDP were decreased in the dorsal horn and increased in large cells in the dorsolateral motor nuclei while CO was decreased in ventral horn neuropil.
Positive_regulation (increased) of AP in horn associated with dorsal horn
20) Confidence 0.15 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507983 Disease Relevance 0 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox