INT55044

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 1.73
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Si) plasma membrane (Si) carbohydrate metabolic process (Si)
Anatomy Link Frequency
skin 3
small intestine 2
ciliary 1
Si (Rattus norvegicus)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 342 100.00 Very High Very High Very High
dexamethasone 2 99.96 Very High Very High Very High
aspirin 12 99.42 Very High Very High Very High
qutenza 18 99.32 Very High Very High Very High
addiction 6 97.32 Very High Very High Very High
imagery 65 91.12 High High
cINOD 5 85.40 High High
ganglionectomy 4 80.40 Quite High
anesthesia 26 79.76 Quite High
abdominal pain 4 78.92 Quite High
Disease Link Frequency Relevance Heat
Gynecomastia 21 100.00 Very High Very High Very High
Kartagener Syndrome 1 99.62 Very High Very High Very High
Movement Disorders 1 98.08 Very High Very High Very High
Body Weight 3 96.80 Very High Very High Very High
INFLAMMATION 3 84.84 Quite High
Toxicity 2 82.84 Quite High
Death 1 80.16 Quite High
Convulsion 1 79.76 Quite High
Diarrhoea 1 79.36 Quite High
Abdominal Pain 4 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ileal expression of sucrase-isomaltase was increased by 1. 6-fold (P < 0.05).
Positive_regulation (increased) of sucrase-isomaltase
1) Confidence 0.24 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10712262 Disease Relevance 0 Pain Relevance 0.08
Henning and collaborators have shown that administration of a synthetic glucocorticoid, dexamethasone, increased the activities of sucrase, trehalase and glucoamylase in the small intestine of weaning rats [11, 13, 14].
Positive_regulation (increased) of sucrase in small intestine associated with dexamethasone
2) Confidence 0.21 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0.08
The intake of only 2.5% sulfite induced an increase in the specific activities of sucrase, maltase, and alkaline phosphatase compared to control levels (P < 0.05).
Positive_regulation (increase) of sucrase
3) Confidence 0.20 Published 1994 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 7958644 Disease Relevance 0.40 Pain Relevance 0.08
Sucrase specific activity in jejunal mucosa was not significantly different; ileal mucosal sucrase specific activity was significantly increased by resection in capsaicin-treated rats.
Positive_regulation (increased) of Sucrase associated with qutenza
4) Confidence 0.13 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17028287 Disease Relevance 0 Pain Relevance 0.69
Sucrase specific activity in jejunal mucosa was not significantly different; ileal mucosal sucrase specific activity was significantly increased by resection in capsaicin-treated rats.
Positive_regulation (increased) of sucrase associated with qutenza
5) Confidence 0.11 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17028287 Disease Relevance 0 Pain Relevance 0.68
About 20-25% of SI cases are associated ciliary dyskinesia syndromes and respiratory symptoms as part of the complex known as Kartagener syndrome [6], however, the cause of SI is currently unknown [7].
Positive_regulation (cause) of SI in ciliary associated with kartagener syndrome, movement disorders and gynecomastia
6) Confidence 0.10 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2803176 Disease Relevance 0.84 Pain Relevance 0
After 28 days, biochemical estimations in both drug treated groups showed an increase in sucrase, lactase, maltase and alkaline phosphatase as compared to the control.
Positive_regulation (increase) of sucrase
7) Confidence 0.10 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16855794 Disease Relevance 0.35 Pain Relevance 0.47
Aspirin and nimesulide exhibited an increase in the brush border membrane (BBM) bound enzyme activities like sucrase, lactase, maltase and alkaline phosphatase in the small intestine while celecoxib showed decrease in lactase, maltase and alkaline phosphatase.
Positive_regulation (increase) of sucrase in small intestine associated with aspirin
8) Confidence 0.02 Published 2006 Journal Nutr Hosp Section Abstract Doc Link 17147060 Disease Relevance 0.07 Pain Relevance 0.28
Measurement of the spatial extent of the activated SI region showed that higher amplitudes of stimulation do not produce a more extensive region of SI activation.
Positive_regulation (activation) of SI associated with primary somatosensory cortex
9) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1166561 Disease Relevance 0 Pain Relevance 0.36
However, the primary focus of their report was that the response to simultaneous stimulation of multiple adjacent sites on the skin produced a smaller, more intense region of SI activation than would be normally predicted by summation of the two, and their findings did not detail the effects of amplitude on the dynamics of the response to a flutter stimulus at a single site on the skin.
Positive_regulation (activation) of SI in skin associated with primary somatosensory cortex
10) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1166561 Disease Relevance 0 Pain Relevance 0.30
Dietary curcumin, capsaicin, piperine and ginger prominantly enhanced intestinal lipase activity and also the disaccharidases sucrase and maltase.
Positive_regulation (enhanced) of disaccharidases sucrase associated with qutenza
11) Confidence 0.01 Published 1996 Journal Int J Food Sci Nutr Section Abstract Doc Link 8616674 Disease Relevance 0 Pain Relevance 0.19
The relatively constant spatial extent of this stimulus-evoked increase in absorbance suggests that an increase in the amplitude of a 25 Hz skin stimulus does not evoke a larger area of SI neuronal activation due to an amplitude-dependent lateral inhibitory effect that spatially funnels the responding SI neuronal population.



Positive_regulation (activation) of SI in skin associated with primary somatosensory cortex
12) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1166561 Disease Relevance 0 Pain Relevance 0.26
Figure 8 suggests that at high amplitudes of stimulation the ROI in SI becomes more homogeneously activated with longer stimulus duration.
Positive_regulation (activated) of SI associated with primary somatosensory cortex
13) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1166561 Disease Relevance 0 Pain Relevance 0.08
An increase in SI absorbance in response to an increase in stimulus intensity has been reported previously by Chen et al [13].
Positive_regulation (increase) of SI associated with primary somatosensory cortex
14) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1166561 Disease Relevance 0.05 Pain Relevance 0.22
The results suggest that increasing the amplitude of a skin flutter stimulus evokes a proportionally larger absorbance increase in SI that remains confined to the same SI territory.
Positive_regulation (increase) of SI in skin associated with primary somatosensory cortex
15) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1166561 Disease Relevance 0 Pain Relevance 0.41

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