INT55047

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.20
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNRHR) signal transducer activity (GNRHR)
Anatomy Link Frequency
follicle 1
brain 1
nucleus 1
endometrium 1
GNRHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 5 98.88 Very High Very High Very High
agonist 6 91.16 High High
Neuropeptide 3 89.64 High High
endometriosis 2 68.40 Quite High
Somatostatin 18 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 30 99.88 Very High Very High Very High
Endometrial Cancer 18 99.68 Very High Very High Very High
Dysmenorrhea 3 98.88 Very High Very High Very High
Disease 20 97.88 Very High Very High Very High
Malignant Neoplastic Disease 5 96.32 Very High Very High Very High
Reprotox - General 1 13 95.84 Very High Very High Very High
Reprotox - General 3 30 94.16 High High
Disease Progression 1 90.72 High High
Adenocarcinoma 3 88.56 High High
Growth Problems 1 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Gn-RH receptor provides a possible point of attack for therapeutic approaches using Gn-RH analogs in this malignancy.
Gene_expression (expression) of Gn-RH receptor associated with malignant neoplastic disease
1) Confidence 0.78 Published 1994 Journal Gynecol. Oncol. Section Abstract Doc Link 7959256 Disease Relevance 0.68 Pain Relevance 0.10
Moreover, the presence of GnRHR in a multitude of non-reproductive tissues including the recent discovery of GnRHR expression in the hippocampi and cortex of the human brain indicates that GnRH analogs such as leuprolide acetate may also act directly via tissue GnRHRs to modulate (brain) function.
Gene_expression (expression) of GnRHR in brain
2) Confidence 0.76 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17970643 Disease Relevance 0.78 Pain Relevance 0.20
Presence of gonadotropin-releasing hormone receptor and its messenger ribonucleic acid in endometrial carcinoma and endometrium.
Gene_expression (Presence) of gonadotropin-releasing hormone in endometrium associated with endometrial cancer
3) Confidence 0.68 Published 1994 Journal Gynecol. Oncol. Section Title Doc Link 7959256 Disease Relevance 0.56 Pain Relevance 0
Gn-RH receptor mRNA was detected in all endometrial carcinoma and endometrial specimens and cell lines where the specific binding sites were detected, but not in adenomyosis or myometrial samples.
Neg (not) Gene_expression (detected) of Gn-RH receptor mRNA associated with dismenorea and endometrial cancer
4) Confidence 0.60 Published 1994 Journal Gynecol. Oncol. Section Abstract Doc Link 7959256 Disease Relevance 0.63 Pain Relevance 0.09
Over the last 50 years of this century, new insight into reproductive processes enabled the following development: hormonal contraception, gonadotropin-releasing hormone (GnRH) and its agonistic and antagonistic analogues, prostaglandins: induction of labor and conquering dysmenorrhea, selective estrogen receptor modulators (SERM), assisted reproductive technologies (ART), and recombinant DNA technology and cloning.
Gene_expression (contraception) of gonadotropin-releasing hormone associated with dismenorea
5) Confidence 0.58 Published 1999 Journal Bratisl Lek Listy Section Abstract Doc Link 10645035 Disease Relevance 0.10 Pain Relevance 0.10
This factor, named gonadotropin-inhibitory hormone (GnIH), is synthesized in neurons of the paraventricular nucleus (PVN) in birds [9]–[13].
Gene_expression (synthesized) of gonadotropin-inhibitory hormone in nucleus
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.04
Some of these pure somatotrope adenomas also express free alpha-subunit, which is common to the glycoprotein hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and chorionic gonadotropin hormone (CG, co-localized in the same cells or even in the same granules as GH) [36].
Gene_expression (express) of gonadotropin hormone in follicle associated with adenoma
7) Confidence 0.20 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 2.07 Pain Relevance 0
Gonadotropin releasing hormone therapy
Gene_expression (therapy) of Gonadotropin releasing hormone
8) Confidence 0.13 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.38 Pain Relevance 0

General Comments

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