INT55048

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNRHR) signal transducer activity (GNRHR)
Anatomy Link Frequency
hypothalamus 2
GNRHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 1 94.80 High High
Neuropeptide 6 68.40 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
endometriosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 6 99.68 Very High Very High Very High
Dysmenorrhea 1 94.80 High High
Adenocarcinoma 1 88.56 High High
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Precocious Puberty 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Appetite Loss 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gn-RH receptor mRNA was detected in all endometrial carcinoma and endometrial specimens and cell lines where the specific binding sites were detected, but not in adenomyosis or myometrial samples.
Neg (not) Transcription (detected) of Gn-RH receptor mRNA associated with dismenorea and endometrial cancer
1) Confidence 0.69 Published 1994 Journal Gynecol. Oncol. Section Abstract Doc Link 7959256 Disease Relevance 0.63 Pain Relevance 0.09
In starlings, GnIH receptor (GPR147) mRNA is expressed in GnRH neurons [19] and we demonstrated expression of the GPR147 in human hypothalamus.
Transcription (expressed) of GnIH receptor in hypothalamus
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0
RT-PCR and subsequent DNA sequencing of the PCR products identified human GnIH receptor (GPR147) mRNA expression in the hypothalamus as well as in the pituitary.
Transcription (expression) of GnIH receptor in hypothalamus
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2791420 Disease Relevance 0 Pain Relevance 0.03

General Comments

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