INT5505

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2010
Negated 4
Speculated 13
Reported most in Abstract
Documents 54
Total Number 67
Disease Relevance 6.96
Pain Relevance 30.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 11
brain 10
pituitary 10
plasma 8
melanocyte 8
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 60 100.00 Very High Very High Very High
Opioid 48 100.00 Very High Very High Very High
antagonist 47 100.00 Very High Very High Very High
Enkephalin 46 100.00 Very High Very High Very High
alcohol 37 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
Serotonin 29 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
opioid receptor 22 100.00 Very High Very High Very High
Dynorphin 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Burns 11 100.00 Very High Very High Very High
Injury 7 100.00 Very High Very High Very High
Sepsis 8 99.84 Very High Very High Very High
Stress 19 99.28 Very High Very High Very High
Depression 18 99.28 Very High Very High Very High
INFLAMMATION 3 99.06 Very High Very High Very High
Hyperalgesia 3 98.92 Very High Very High Very High
Pain 5 98.72 Very High Very High Very High
Hypotension 2 97.60 Very High Very High Very High
Hypoglycemia 5 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effects of the opiate antagonist naloxone on the release of beta-endorphin and cortisol in rats subjected to sepsis.
Spec (investigated) Regulation (effects) of Localization (release) of beta-endorphin associated with antagonist, narcan, opiate and sepsis
1) Confidence 0.61 Published 1996 Journal Res Exp Med (Berl) Section Abstract Doc Link 8903101 Disease Relevance 0.32 Pain Relevance 0.28
Herein, the microdialysis method was used to assess in vivo the effects of serotonin on beta-endorphin release in a rat model of depressive behavior (the Flinders sensitive line, FSL), before and after antidepressant treatment.
Regulation (effects) of Localization (release) of beta-endorphin associated with antidepressant, depression and serotonin
2) Confidence 0.61 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.27 Pain Relevance 0.61
Similar effects on beta-endorphin secretion were observed with the selective mu-opioid agonist dermorphin.
Regulation (effects) of Localization (secretion) of beta-endorphin associated with mu agonist
3) Confidence 0.61 Published 2000 Journal Neuropeptides Section Abstract Doc Link 10688972 Disease Relevance 0 Pain Relevance 0.93
Caffeine treatment did not effect CSF beta-endorphin levels or the release of beta-endorphin from hemipituitaries incubated in vitro.
Neg (not) Regulation (effect) of Localization (release) of beta-endorphin
4) Confidence 0.60 Published 1982 Journal Life Sci. Section Abstract Doc Link 6290811 Disease Relevance 0 Pain Relevance 0.22
Significance of testosterone in regulating hypothalamic content and in vitro release of beta-endorphin and dynorphin.
Regulation (regulating) of Localization (release) of beta-endorphin associated with dynorphin
5) Confidence 0.59 Published 1987 Journal J. Neurochem. Section Title Doc Link 2886553 Disease Relevance 0 Pain Relevance 0.19
A pharmacological approach was used to investigate serotonergic control of the secretion of pituitary beta-endorphin-like immunoreactivity (beta-END-LI) in the rat.
Spec (investigate) Regulation (control) of Localization (secretion) of pituitary beta-endorphin-like immunoreactivity in pituitary
6) Confidence 0.59 Published 1981 Journal Endocrinology Section Abstract Doc Link 6265189 Disease Relevance 0 Pain Relevance 0.18
Our data support a role for local mu-opioid receptor control of intermediate lobe pro-opiomelanocortin peptide secretion.
Regulation (control) of Localization (secretion) of pro-opiomelanocortin peptide in lobe associated with opioid receptor
7) Confidence 0.53 Published 2000 Journal Neuropeptides Section Abstract Doc Link 10688972 Disease Relevance 0 Pain Relevance 0.95
Cocaine influences beta-endorphin levels and release.
Regulation (influences) of Localization (release) of beta-endorphin associated with cocaine
8) Confidence 0.52 Published 1988 Journal Life Sci. Section Title Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.35
Relatively little is known about the regulation of secretion of hypothalamic beta-endorphin, the potent opioid that is believed to play a variety of physiological roles in brain.
Regulation (regulation) of Localization (secretion) of beta-endorphin in brain associated with opioid
9) Confidence 0.46 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1422853 Disease Relevance 0 Pain Relevance 0.24
Thus, painful inflammation enhances signal sequence-encoding lymphocytic POMC mRNA needed for regulated secretion of functionally active END.
Regulation (regulated) of Localization (secretion) of POMC mRNA associated with pain and inflammation
10) Confidence 0.45 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17223201 Disease Relevance 0.43 Pain Relevance 0.47
As a test of the hypothesis that an animal responds to a severe peripheral painful stimulus by a central release of beta-endorphin, antibody microprobes were inserted stereotactically into the midbrain of urethane anesthetized rats.
Regulation (responds) of Localization (release) of beta-endorphin in midbrain associated with pain and midbrain
11) Confidence 0.45 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8474693 Disease Relevance 0.07 Pain Relevance 0.19
[Study of the effect of analgeton on the release of beta-endorphin and its effect on chronic hyperalgesia].
Regulation (effect) of Localization (release) of beta-endorphin associated with hyperesthesia and hyperalgesia
12) Confidence 0.45 Published 1989 Journal Eksp Med Morfol Section Title Doc Link 2530083 Disease Relevance 0.34 Pain Relevance 0.55
However, the chronic antidepressant treatment did normalize the serotonin-induced release of beta-endorphin in FSL rats, as well as their behavioral manifestation of depressive behavior.
Regulation (normalize) of Localization (release) of beta-endorphin associated with antidepressant, depression and serotonin
13) Confidence 0.45 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.41 Pain Relevance 0.78
The present study aimed to evaluate, in 12 healthy postmenopausal women, the effect of 60 mg/day raloxifene hydrochloride administration for 6 months on plasma beta-endorphin and allopregnanolone levels, and on the dynamic changes of both beta-endorphin and allopregnanolone secretion after the administration of: (1) clonidine, an alpha 2-presynaptic adrenergic agonist; (2) naloxone, an opioid receptor antagonist; and (3) fluoxetine, a serotonin selective reuptake inhibitor.
Regulation (changes) of Localization (secretion) of beta-endorphin in plasma associated with antagonist, narcan, agonist, opioid receptor, serotonin, fluoxetine and clonidine
14) Confidence 0.44 Published 2001 Journal Gynecol. Endocrinol. Section Abstract Doc Link 11727358 Disease Relevance 0 Pain Relevance 0.73
To further explore the effects of burn trauma on the peripheral release of beta-endorphin and the occurrence of centrally mediated stress analgesia, plasma iB-EP levels and tail flick latency (TFL) were measured in rats subjected (while anesthetized) to scald injury.
Regulation (effects) of Localization (release) of beta-endorphin in plasma associated with stress, burns, injury, tail-flick and analgesia
15) Confidence 0.44 Published 1987 Journal Life Sci. Section Abstract Doc Link 2949129 Disease Relevance 1.43 Pain Relevance 0.36
In the present study we examined the effects of central administration of EP on ACTH secretion and gene expression of both CRF in the hypothalamus and POMC in the anterior pituitary gland (AP) during basal and insulin-induced hypoglycemia in pentobarbital-anesthetized rats.
Spec (examined) Regulation (effects) of Localization (secretion) of POMC in anterior pituitary associated with hypoglycemia
16) Confidence 0.44 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.38 Pain Relevance 0.15
[The inhibition of yohimbine injected intrathecally on electroacupuncture-induced analgesia and release of beta-endorphin from rat brain].
Regulation (injected) of Localization (release) of beta-endorphin in brain associated with electroacupuncture and analgesia
17) Confidence 0.43 Published 1996 Journal Zhen Ci Yan Jiu Section Title Doc Link 9387357 Disease Relevance 0.17 Pain Relevance 0.93
The effects of castration and testosterone replacement on hypothalamic pools of beta-endorphin and dynorphin and on the basal and corticotropin-releasing factor (CRF)-stimulated release of these peptides from hypothalamic slices in vitro were studied.
Regulation (effects) of Localization (release) of beta-endorphin associated with dynorphin
18) Confidence 0.43 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2886553 Disease Relevance 0 Pain Relevance 0.12
The sites in the brainstem most sensitive to beta-endorphin (2 micrograms) for inhibition of the tail-flick response and Met-enkephalin release were located in areas in the caudal medial medulla such as raphe obsacurus nucleus and raphe pallidus nucleus and the adjacent midline reticular formation.
Regulation (sensitive) of Localization (release) of beta-endorphin in midline associated with medulla, tail-flick, enkephalin and raphe
19) Confidence 0.42 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2141638 Disease Relevance 0 Pain Relevance 1.61
Forebrain sites differentially sensitive to beta-endorphin and morphine for analgesia and release of Met-enkephalin in the pentobarbital-anesthesized rat.
Regulation (sensitive) of Localization (release) of beta-endorphin in Forebrain associated with anesthesia, enkephalin, analgesia and morphine
20) Confidence 0.41 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1318368 Disease Relevance 0.08 Pain Relevance 1.28

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