INT55052

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.46
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 3
spinal cord 1
brain 1
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 99.74 Very High Very High Very High
Sciatic nerve 1 98.70 Very High Very High Very High
Spinal cord 4 97.20 Very High Very High Very High
adenocard 1 94.68 High High
Inflammatory response 4 93.64 High High
cytokine 2 90.76 High High
ischemia 34 89.16 High High
medulla 21 84.40 Quite High
Hyperalgesia 1 77.12 Quite High
Chronic pancreatitis 1 74.04 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.74 Very High Very High Very High
Stress 68 99.40 Very High Very High Very High
Diabetes Mellitus 115 96.64 Very High Very High Very High
Injury 50 95.32 Very High Very High Very High
Nociception 2 94.96 High High
INFLAMMATION 26 93.28 High High
Increased Venous Pressure Under Development 69 91.84 High High
Adhesions 1 91.48 High High
Neurological Disease 1 91.16 High High
Cv Unclassified Under Development 33 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol is metabolized in the brain by catalase/H2O2 to yield acetaldehyde and by an ethanol-inducible form of cytochrome P450 (P450 IIE1) in a reaction that yields oxygen radicals.
catalase Binding (metabolized) of in brain
1) Confidence 0.36 Published 1997 Journal Alcohol Section Abstract Doc Link 9160798 Disease Relevance 0.15 Pain Relevance 0
This drug also inhibits catalase activity, thus increasing endogenous H2O2.5
catalase Binding (activity) of
2) Confidence 0.31 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020346 Disease Relevance 0.16 Pain Relevance 0.04
In this study, rats were submitted to sciatic nerve transection (SNT) for induction of neuropathic pain, and enzyme activities of SOD and catalase as well as lipid peroxidation (LPO) were measured in the lumbosacral spinal cord.
catalase Binding (activities) of in spinal cord associated with neuropathic pain, sciatic nerve and spinal cord
3) Confidence 0.29 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16770731 Disease Relevance 0.53 Pain Relevance 0.42
Vascular reactivity in the presence of the hydrogen peroxide scavenger catalase (1200 U/mL) or an inhibitor of cyclooxygenase (COX) (indomethacin, 10 ?
catalase Binding (indomethacin) of
4) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.35 Pain Relevance 0
Catalase assay
Catalase Binding (assay) of
5) Confidence 0.21 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1291371 Disease Relevance 0 Pain Relevance 0.12
The antioxidant system has an important role in protection from the damage of oxidative stress.16,21,23,26 In our study, by measuring the liver tissue catalase, paraoxonase, arylesterase, ceruloplasmin, and lipid hydroperoxide levels, we obtained information about hepatic IR injury.
catalase Binding (measuring) of in liver associated with stress and injury
6) Confidence 0.18 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 1.13 Pain Relevance 0.20
In both models, a combination of catalase and superoxide dismutase effectively prevented cell damage.
catalase Binding (combination) of
7) Confidence 0.15 Published 1994 Journal Hepatogastroenterology Section Abstract Doc Link 7959563 Disease Relevance 0.44 Pain Relevance 0.12
Effects of P. persica methanol extract on liver superoxide dismutase, catalase and glutathione peroxidase
catalase Binding (extract) of in liver
8) Confidence 0.15 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2950386 Disease Relevance 1.03 Pain Relevance 0
Effects of P. persica methanol extract on liver superoxide dismutase, catalase and glutathione peroxidase
catalase Binding (liver) of in liver
9) Confidence 0.15 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2950386 Disease Relevance 1.03 Pain Relevance 0
Similar results were also found with SOD and catalase, which were increased by treatment with the extract.
catalase Binding (found) of
10) Confidence 0.11 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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