INT5506

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2010
Negated 7
Speculated 9
Reported most in Abstract
Documents 132
Total Number 141
Disease Relevance 26.78
Pain Relevance 54.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
plasma 23
pituitary 18
hypothalamus 17
NAS 14
arcuate nucleus 13
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 108 100.00 Very High Very High Very High
Morphine 106 100.00 Very High Very High Very High
Enkephalin 75 100.00 Very High Very High Very High
Nucleus accumbens 60 100.00 Very High Very High Very High
Endogenous opioid 57 100.00 Very High Very High Very High
Analgesic 38 100.00 Very High Very High Very High
opiate 29 100.00 Very High Very High Very High
Versed 20 100.00 Very High Very High Very High
antagonist 174 99.98 Very High Very High Very High
electroacupuncture 147 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 205 100.00 Very High Very High Very High
Urological Neuroanatomy 57 100.00 Very High Very High Very High
Aids-related Complex 34 100.00 Very High Very High Very High
Nociception 32 100.00 Very High Very High Very High
Shock 21 100.00 Very High Very High Very High
Hypoglycemia 5 99.98 Very High Very High Very High
Endotoxemia 2 99.90 Very High Very High Very High
Hyperglycemia 6 99.52 Very High Very High Very High
Liver Failure 2 98.88 Very High Very High Very High
Diabetes Mellitus 35 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus.
Positive_regulation (increases) of Gene_expression (expression) of proopiomelanocortin in arcuate nucleus
1) Confidence 0.70 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9128838 Disease Relevance 0 Pain Relevance 0.21
RESULT: EOAD could increase beta-endorphin, NO and the amount of masculine cell expression of Proopiomelanocortin mRNA significantly in hypothalamus and brainstem of rats.
Positive_regulation (increase) of Gene_expression (expression) of Proopiomelanocortin mRNA in brainstem
2) Confidence 0.70 Published 2002 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776573 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: The POMC gene can be transferred in the bladder using the gene gun and increased bladder expression of endorphin can suppress nociceptive responses induced by bladder irritation.
Positive_regulation (transferred) of Gene_expression (transferred) of POMC gene in bladder
3) Confidence 0.70 Published 2003 Journal J. Urol. Section Body Doc Link 14532850 Disease Relevance 0.05 Pain Relevance 0
In this study we developed a gene gun method for the transfer of POMC cDNA in vivo and investigated its therapeutic effect on acetic acid induced bladder hyperactivity in rats.
Positive_regulation (transfer) of Gene_expression (transfer) of POMC cDNA in bladder associated with attention deficit hyperactivity disorder
4) Confidence 0.70 Published 2003 Journal J. Urol. Section Abstract Doc Link 14532850 Disease Relevance 0.61 Pain Relevance 0.43
CONCLUSIONS: The POMC gene can be transferred in the bladder using the gene gun and increased bladder expression of endorphin can suppress nociceptive responses induced by bladder irritation.
Positive_regulation (increased) of Gene_expression (expression) of endorphin in bladder
5) Confidence 0.70 Published 2003 Journal J. Urol. Section Body Doc Link 14532850 Disease Relevance 0 Pain Relevance 0
In this study, we developed a gene-gun method for the transfer of POMC cDNA in vivo, and investigated its therapeutic effect on inflammatory pain in a rat model of formalin-induced pain.
Positive_regulation (transfer) of Gene_expression (transfer) of POMC cDNA associated with pain and ipn
6) Confidence 0.70 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12101431 Disease Relevance 0.42 Pain Relevance 0.61
Increase of beta-endorphin biosynthesis in the adrenal gland of streptozotocin-induced diabetic rats.
Positive_regulation (Increase) of Gene_expression (biosynthesis) of beta-endorphin in adrenal gland associated with diabetes mellitus
7) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11796185 Disease Relevance 0.57 Pain Relevance 0.20
These results suggest that hyperglycemia is responsible for the increase of POMC gene expression to enhance beta-endorphin biosynthesis in the adrenal gland of STZ-diabetic rats.
Positive_regulation (increase) of Gene_expression (expression) of POMC gene in adrenal gland associated with hyperglycemia and diabetes mellitus
8) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.87 Pain Relevance 0.08
These results suggest that hyperglycemia is responsible for the increase of POMC gene expression to enhance beta-endorphin biosynthesis in the adrenal gland of STZ-diabetic rats.
Positive_regulation (enhance) of Gene_expression (biosynthesis) of beta-endorphin in adrenal gland associated with hyperglycemia and diabetes mellitus
9) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.81 Pain Relevance 0.08
RIA and RT-PCR both showed increased expression of beta-endorphin in group D.
Positive_regulation (increased) of Gene_expression (expression) of beta-endorphin
10) Confidence 0.70 Published 2003 Journal Pain Section Abstract Doc Link 12855325 Disease Relevance 0.17 Pain Relevance 0.79
There was an increase in the number of beta-endorphin-immunoreactive cells in the arcuate nucleus and an increase in the density of beta-endorphin fibres within the supraoptic nucleus and peri-supraoptic region in late pregnancy and parturition, suggesting enhanced expression of beta-endorphin and increased beta-endorphin innervation of the supraoptic nucleus.
Positive_regulation (enhanced) of Gene_expression (expression) of beta-endorphin in supraoptic nucleus
11) Confidence 0.70 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372001 Disease Relevance 0 Pain Relevance 0.07
Pro-opiomelanocortin mRNA expression in the arcuate nucleus increased in late compared to early pregnancy: the number of positive neurones significantly increased in the caudal region.
Positive_regulation (increased) of Gene_expression (expression) of Pro-opiomelanocortin mRNA in arcuate nucleus
12) Confidence 0.70 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372001 Disease Relevance 0 Pain Relevance 0.12
We have previously demonstrated that testosterone stimulates POMC gene expression in neurons of the arcuate nucleus.
Positive_regulation (stimulates) of Gene_expression (expression) of POMC gene in neurons
13) Confidence 0.69 Published 1989 Journal Endocrinology Section Abstract Doc Link 2721451 Disease Relevance 0 Pain Relevance 0.09
The density of beta-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment.
Positive_regulation (increases) of Gene_expression (expression) of POMC mRNA in MPOA associated with urological neuroanatomy
14) Confidence 0.69 Published 1994 Journal Horm Behav Section Abstract Doc Link 7729811 Disease Relevance 0.76 Pain Relevance 0.59
This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course.
Positive_regulation (increased) of Gene_expression (expression) of POMC mRNA in median eminence
15) Confidence 0.69 Published 1994 Journal Horm Behav Section Abstract Doc Link 7729811 Disease Relevance 0.69 Pain Relevance 0.52
In daily repeated exercise the production of beta-endorphin increases and exceeds the elevated release in hypophysis and adrenals.
Positive_regulation (increases) of Gene_expression (production) of beta-endorphin in hypophysis
16) Confidence 0.69 Published 1991 Journal Int J Sports Med Section Abstract Doc Link 1752719 Disease Relevance 0 Pain Relevance 0.10
However, the de novo biosynthesis of beta-endorphin and its prohormones beta-lipotropin and pro-opiomelanocortin was increased in the intermediate pituitary and to an even more pronounced degree, in the adenohypophysis, after chronic treatment of rats with ethanol liquid diet, nevertheless, the amounts of opiate-active beta-endorphin were found to be reduced in both lobes of the pituitary: In the adenohypophysis, this was due to a retardation of the enzymatic processing of beta-endorphin from its precursor beta-lipotropin, while in the intermediate pituitary the alpha-N-acetylation of beta-endorphin to opiate-inactive alpha-N-acetyl-beta-endorphin was stimulated.
Positive_regulation (increased) of Gene_expression (biosynthesis) of beta-lipotropin in adenohypophysis associated with opiate
17) Confidence 0.68 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6138772 Disease Relevance 0 Pain Relevance 0.75
Beta-endorphin precursor mRNA expression increased with LLLT, both in vivo and in vitro.
Positive_regulation (increased) of Gene_expression (expression) of Beta-endorphin precursor mRNA
18) Confidence 0.68 Published 2007 Journal Lasers Surg Med Section Body Doc Link 18081143 Disease Relevance 0 Pain Relevance 0
These findings, that the effects of morphine on HPA activation or POMC mRNA expression depend on the presence of stress, suggest a counter-regulatory role of opiates on a stress response and opioid gene expression.
Positive_regulation (depend) of Gene_expression (expression) of POMC mRNA associated with stress, opiate, opioid and morphine
19) Confidence 0.68 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10556776 Disease Relevance 0.33 Pain Relevance 0.96
STUDY DESIGN: The effect of proopiomelanocortin (POMC) gene transfer with radial shock waves (RSW) was investigated in vitro and in vivo rat pain models.
Positive_regulation (transfer) of Gene_expression (transfer) of POMC in radial associated with pain and shock
20) Confidence 0.67 Published 2009 Journal Spine Section Abstract Doc Link 19934807 Disease Relevance 0.35 Pain Relevance 0.17

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