INT5507

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2009
Negated 5
Speculated 13
Reported most in Abstract
Documents 57
Total Number 70
Disease Relevance 8.43
Pain Relevance 30.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 29
blood 12
melanocyte 6
plasma 4
pituitary 4
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 145 100.00 Very High Very High Very High
narcan 100 100.00 Very High Very High Very High
antagonist 67 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
Opioid 51 100.00 Very High Very High Very High
Enkephalin 45 100.00 Very High Very High Very High
opiate 39 100.00 Very High Very High Very High
Neuropeptide 36 100.00 Very High Very High Very High
Serotonin 27 100.00 Very High Very High Very High
opioid receptor 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 7 100.00 Very High Very High Very High
Morphine Dependence 2 100.00 Very High Very High Very High
Pain 9 99.42 Very High Very High Very High
Stress 142 99.32 Very High Very High Very High
Depression 5 98.84 Very High Very High Very High
INFLAMMATION 94 97.68 Very High Very High Very High
Hypoglycemia 10 96.00 Very High Very High Very High
Colitis 4 95.12 Very High Very High Very High
Ileus 2 94.72 High High
Cystitis 1 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of beta-endorphin on the secretion of corticotrophin releasing factor (CRF) by isolated rat hypothalami in vitro was studied. beta-Endorphin (10(-11)-10(-10) M) caused dose-related increases in the CRF contents of the hypothalami and of the medium in which they were incubated.
Regulation (influence) of Localization (secretion) of corticotrophin releasing factor
1) Confidence 0.61 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2936971 Disease Relevance 0 Pain Relevance 0.21
It is possible that CRH secretion from the posterior pituitary gland is at least partly responsible for the persistent plasma ACTH increase in ether-laparotomy stress.
Regulation (responsible) of Localization (secretion) of CRH in plasma associated with stress
2) Confidence 0.61 Published 1993 Journal Endocr. J. Section Abstract Doc Link 7951507 Disease Relevance 0.51 Pain Relevance 0
The effects of selective agonists and antagonists of opioid receptors on the secretion of corticotrophin releasing factor (CRF) by isolated rat hypothalami in vitro were studied.
Regulation (effects) of Localization (secretion) of CRF associated with antagonist, agonist and opioid receptor
3) Confidence 0.61 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3024056 Disease Relevance 0 Pain Relevance 0.67
Hypothalamic corticotropin-releasing hormone (CRH) secretion into hypophysial portal blood is regulated by cutaneous sensory stimulation in anesthetized rats.
Regulation (regulated) of Localization (secretion) of Hypothalamic corticotropin-releasing hormone in blood
4) Confidence 0.61 Published 1992 Journal Jpn. J. Physiol. Section Title Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.13
A survey of neural inputs to the hypophyseotropic zone of the PVH suggests potential substrates for the control of CRF release and/or synthesis by interoceptive stimuli, by the limbic region, and by a number of cell groups in the basal forebrain.
Regulation (control) of Localization (release) of CRF in forebrain
5) Confidence 0.61 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981743 Disease Relevance 0 Pain Relevance 0.13
Interrelationships of opioidergic and adrenergic mechanisms controlling the secretion of corticotrophin releasing factor in the rat.
Regulation (controlling) of Localization (secretion) of corticotrophin releasing factor associated with narcan
6) Confidence 0.59 Published 1987 Journal Neuroendocrinology Section Title Doc Link 2821423 Disease Relevance 0.28 Pain Relevance 0.50
The effects of castration and testosterone replacement on hypothalamic pools of beta-endorphin and dynorphin and on the basal and corticotropin-releasing factor (CRF)-stimulated release of these peptides from hypothalamic slices in vitro were studied.
Regulation (effects) of Localization (release) of CRF associated with dynorphin
7) Confidence 0.59 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2886553 Disease Relevance 0 Pain Relevance 0.12
Interleukin-1 beta (IL-1 beta) is involved in hypothalamic regulation of corticotropin releasing hormone (CRH) secretion and consequent downstream modulation of the neuroimmune response.
Regulation (regulation) of Localization (secretion) of corticotropin releasing hormone
8) Confidence 0.59 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535154 Disease Relevance 0 Pain Relevance 0.07
The influence of opioid substances on the secretion in vivo and in vitro of corticosterone, corticotrophin (ACTH) and corticotrophin releasing factor (CRF) in the rat was studied.
Regulation (influence) of Localization (secretion) of CRF associated with opioid
9) Confidence 0.58 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328347 Disease Relevance 0.16 Pain Relevance 0.57
However, the results indicate that morphine and stadol change HPA activity by acting on specific receptors in the hypothalamus and raise the possibility that opioid peptides and their receptors are physiologically important in the control of the secretion of CRH.
Regulation (control) of Localization (secretion) of CRH in hypothalamus associated with opioid and morphine
10) Confidence 0.55 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950285 Disease Relevance 0.14 Pain Relevance 0.58
The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies.
Regulation (regulation) of Localization (release) of hypothalamic corticotropin-releasing factor
11) Confidence 0.54 Published 1993 Journal Ciba Found. Symp. Section Title Doc Link 8491084 Disease Relevance 0.08 Pain Relevance 0.29
Effects of catecholamines on immunoreactive corticotropin-releasing factor (I-CRF) release from the rat hypothalamus were examined using a rat hypothalamic perifusion system and a rat CRF RIA in vitro.
Spec (examined) Regulation (Effects) of Localization (release) of I-CRF in hypothalamus associated with catecholamine
12) Confidence 0.52 Published 1987 Journal Life Sci. Section Abstract Doc Link 2882402 Disease Relevance 0 Pain Relevance 0.15
The results indicate that morphine and the enkephalins evoke hypothalamo-pituitary-adrenocortical activity by stimulating specific receptors in the hypothalamus and raise the possibility that opioid peptides and their receptors are physiologically important in the control of the secretion of CRF.
Regulation (important) of Localization (secretion) of CRF in hypothalamus associated with enkephalin, opioid and morphine
13) Confidence 0.52 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6290921 Disease Relevance 0.07 Pain Relevance 1.20
To accomplish this, we first explored the effect of the sodium channel blocker tetrodotoxin (TTX) on basal and stimulated immunoreactive CRH (iCRH) secretion by explanted rat hypothalami.
Regulation (effect) of Localization (secretion) of CRH associated with tetrodotoxin and sodium channel
14) Confidence 0.45 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.16 Pain Relevance 1.09
The influence of beta-endorphin on the secretion of corticotrophin releasing factor (CRF) by isolated rat hypothalami in vitro was studied. beta-Endorphin (10(-11)-10(-10) M) caused dose-related increases in the CRF contents of the hypothalami and of the medium in which they were incubated.
Regulation (influence) of Localization (secretion) of CRF
15) Confidence 0.45 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2936971 Disease Relevance 0 Pain Relevance 0.21
The effects of selective agonists and antagonists of opioid receptors on the secretion of corticotrophin releasing factor (CRF) by isolated rat hypothalami in vitro were studied.
Regulation (effects) of Localization (secretion) of corticotrophin releasing factor associated with antagonist, agonist and opioid receptor
16) Confidence 0.45 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3024056 Disease Relevance 0 Pain Relevance 0.67
Hypothalamic corticotropin-releasing hormone (CRH) secretion into hypophysial portal blood is regulated by cutaneous sensory stimulation in anesthetized rats.
Regulation (regulated) of Localization (secretion) of CRH in blood
17) Confidence 0.45 Published 1992 Journal Jpn. J. Physiol. Section Title Doc Link 1434108 Disease Relevance 0 Pain Relevance 0.13
Because CRF may serve as a neurotransmitter in the locus coeruleus (LC), it was proposed that CRF hypersecretion in the LC is responsible for some characteristics of depression, and that antidepressants act by interfering with CRF neurotransmission in the LC.
Regulation (responsible) of Localization (hypersecretion) of CRF in locus coeruleus associated with antidepressant, neurotransmitter, depression and locus ceruleus
18) Confidence 0.44 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7859115 Disease Relevance 0.20 Pain Relevance 0.79
In the present study we examined the effects of central administration of EP on ACTH secretion and gene expression of both CRF in the hypothalamus and POMC in the anterior pituitary gland (AP) during basal and insulin-induced hypoglycemia in pentobarbital-anesthetized rats.
Spec (examined) Regulation (effects) of Localization (secretion) of CRF in anterior pituitary associated with hypoglycemia
19) Confidence 0.44 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.32 Pain Relevance 0.15
The effects of castration and testosterone replacement on hypothalamic pools of beta-endorphin and dynorphin and on the basal and corticotropin-releasing factor (CRF)-stimulated release of these peptides from hypothalamic slices in vitro were studied.
Regulation (effects) of Localization (release) of corticotropin-releasing factor associated with dynorphin
20) Confidence 0.43 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2886553 Disease Relevance 0 Pain Relevance 0.12

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