INT5509

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 91
Total Number 101
Disease Relevance 30.65
Pain Relevance 53.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 38
nucleus 10
CeA 10
pituitary 10
neurons 6
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 87 100.00 Very High Very High Very High
amygdala 73 100.00 Very High Very High Very High
Locus ceruleus 56 100.00 Very High Very High Very High
Eae 10 100.00 Very High Very High Very High
Morphine 126 99.98 Very High Very High Very High
agonist 102 99.98 Very High Very High Very High
cocaine 66 99.98 Very High Very High Very High
lidocaine 35 99.98 Very High Very High Very High
anesthesia 21 99.98 Very High Very High Very High
Kappa opioid receptor 12 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 579 99.98 Very High Very High Very High
Hypoglycemia 18 99.98 Very High Very High Very High
Hypotension 5 99.74 Very High Very High Very High
INFLAMMATION 409 99.44 Very High Very High Very High
Disease 137 99.44 Very High Very High Very High
Opiate Addiction 2 99.42 Very High Very High Very High
Depression 61 99.34 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

5 99.06 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

202 98.90 Very High Very High Very High
Functional Bowel Disorder 10 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that procaine and lidocaine stimulate corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami.
Positive_regulation (stimulate) of Localization (secretion) of CRH associated with lidocaine
1) Confidence 0.70 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.17 Pain Relevance 0.37
In early-life psychological stress such as maternal separation, chronic pain occurs later in life due to dysregulation of the hypothalamic-pituitary-adrenal axis and significant increase in corticotrophin releasing factor (CRF) secretion.
Positive_regulation (increase) of Localization (secretion) of corticotrophin releasing factor in pituitary associated with stress and lasting pain
2) Confidence 0.69 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 19655104 Disease Relevance 1.55 Pain Relevance 1.07
Naloxone (10(-7)-10(-5) M) had no significant effect on either basal or norepinephrine-induced CRF-41 release, but reversed the inhibitory effect of morphine on norepinephrine-induced CRF-41 secretion in a dose-dependent manner.
Positive_regulation (induced) of Localization (release) of CRF-41 associated with narcan and morphine
3) Confidence 0.69 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.28
The effect of 5-HT is predominantly indirect and may be mediated via release of hypothalamic corticotropin-releasing hormone (CRH).
Spec (may) Positive_regulation (mediated) of Localization (release) of CRH
4) Confidence 0.68 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.20
To test this hypothesis, the acute and chronic effects of four antidepressants and cocaine were characterized on LC spontaneous and sensory-evoked discharge, LC activation by a stressor that requires CRF release, and LC activation by exogenously administered CRF.
Positive_regulation (requires) of Localization (release) of CRF associated with antidepressant, locus ceruleus and cocaine
5) Confidence 0.68 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7859115 Disease Relevance 0.32 Pain Relevance 0.94
Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation.
Positive_regulation (stimulates) of Localization (release) of CRF in median eminence associated with morphine
6) Confidence 0.67 Published 1998 Journal Brain Res. Section Title Doc Link 9593913 Disease Relevance 0 Pain Relevance 0.63
Exposure of ARC/PVN cocultures to the glucocorticoid dexamethasone (DEX) resulted in a dose-dependent increase of CRH secretion and an inhibition of AVP and beta-END; the CRH responses deviated strikingly from predictions based on in vivo experiments.
Positive_regulation (increase) of Localization (secretion) of CRH associated with aids-related complex and dexamethasone
7) Confidence 0.66 Published 1998 Journal FASEB J. Section Abstract Doc Link 9472985 Disease Relevance 0.26 Pain Relevance 0.56
Hypercortisolism in depression seems to preferentially reflect activation of hypothalamic CRH secretion.
Positive_regulation (activation) of Localization (secretion) of CRH associated with depression
8) Confidence 0.63 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8597444 Disease Relevance 0.83 Pain Relevance 0.34
These changes are primarily dependent upon increased release of corticotropin-releasing factor (CRF) into the portal circulation, and recent studies have indicated that the paraventricular nucleus (PVN) of the hypothalamus is the main source of this CRF.
Positive_regulation (dependent) of Localization (release) of corticotropin-releasing factor in hypothalamus
9) Confidence 0.63 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.08
Procaine and lidocaine stimulate corticotropin-releasing hormone secretion by explanted rat hypothalami through a sodium conductance-independent mechanism.
Positive_regulation (stimulate) of Localization (secretion) of corticotropin-releasing hormone associated with lidocaine
10) Confidence 0.61 Published 1990 Journal Horm. Metab. Res. Section Title Doc Link 1968416 Disease Relevance 0.17 Pain Relevance 0.77
Naloxone (10(-7)-10(-5) M) had no significant effect on either basal or norepinephrine-induced CRF-41 release, but reversed the inhibitory effect of morphine on norepinephrine-induced CRF-41 secretion in a dose-dependent manner.
Positive_regulation (induced) of Localization (secretion) of CRF-41 associated with narcan and morphine
11) Confidence 0.60 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.17
Morphine (10(-8)-10(-6) M) and the mu-opioid receptor agonists, FK33-824CH (10(-8)-10(-6) M) and Tyr-D-Ala-Gly-MePhe-NH(CH2)2OH (10(-8)-10(-6) M), caused dose-related increases in the release of CRF from isolated hypothalami.
Positive_regulation (increases) of Localization (release) of CRF associated with agonist, opioid receptor and morphine
12) Confidence 0.60 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3024056 Disease Relevance 0 Pain Relevance 0.88
It also stimulated the secretion of CRF by hypothalami in vitro.
Positive_regulation (stimulated) of Localization (secretion) of CRF
13) Confidence 0.58 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.36 Pain Relevance 0.50
Irritable bowel syndrome (IBS) is known to be related to stress, which is likely to induce corticotrophin-releasing factor (CRF) release (1).
Positive_regulation (induce) of Localization (release) of corticotrophin-releasing factor in bowel associated with stress and spastic colon
14) Confidence 0.54 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.85 Pain Relevance 0.35
Since stress is known to be closely related to IBS, our results of the present study provide evidence that stress-mediated release of CRF may play a role in increasing mast cell number in IBS.
Positive_regulation (mediated) of Localization (release) of CRF in mast cell associated with stress and spastic colon
15) Confidence 0.54 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.95 Pain Relevance 0.74
Dynorphin can exert dual actions on adrenocorticotropin (ACTH) release: (i) via activation of hypothalamic kappa-opioid receptors leading to release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), and (ii) via a non-opioid mechanism that involves N-methyl-D-aspartate (NMDA) receptors and prostaglandins, and which is not dependent on CRH or AVP.
Positive_regulation (leading) of Localization (release) of CRH associated with dynorphin, kappa opioid receptor and opioid
16) Confidence 0.51 Published 2003 Journal Life Sci. Section Abstract Doc Link 12801596 Disease Relevance 0 Pain Relevance 0.75
At a central level increased activity in the noradrenergic locus coeruleus (LC) and an enhanced secretion of corticotrophin-releasing factor (CRF) and vasopressin produced in the paraventricular nucleus (PVN) integrate stress response.
Positive_regulation (enhanced) of Localization (releasing) of CRF in nucleus associated with stress and locus ceruleus
17) Confidence 0.51 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.24 Pain Relevance 0.10
To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent animals injected with saline or 5 mg/kg naloxone.
Positive_regulation (induction) of Localization (secretion) of CRH in hypothalamus associated with narcan, withdrawal, opioid and morphine
18) Confidence 0.50 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286593 Disease Relevance 0.17 Pain Relevance 1.05
To reveal secretory, activational and transcriptional changes in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) in naïve and morphine dependent animals injected with saline or 5 mg/kg naloxone.
Positive_regulation (induction) of Localization (secretion) of corticotropin-releasing hormone in hypothalamus associated with narcan, withdrawal, opioid and morphine
19) Confidence 0.50 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286593 Disease Relevance 0.17 Pain Relevance 1.05
There is evidence that suggests that increased corticotropin-releasing hormone (CRH) release in the central nucleus of the amygdala underlies the anxiogenic and stress-like consequences of withdrawal that are common in phenomenology to all drugs of abuse.
Positive_regulation (increased) of Localization (release) of CRH in amygdala associated with stress, withdrawal and amygdala
20) Confidence 0.50 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.23 Pain Relevance 0.39

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