INT55090

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Context Info
Confidence 0.37
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.25
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt7a) extracellular space (Wnt7a) extracellular region (Wnt7a)
proteinaceous extracellular matrix (Wnt7a) plasma membrane (Wnt7a) cell-cell signaling (Wnt7a)
Anatomy Link Frequency
liver 2
hepatocytes 1
Wnt7a (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 99.30 Very High Very High Very High
Paracetamol 22 98.00 Very High Very High Very High
fluoxetine 1 75.64 Quite High
Hippocampus 1 71.92 Quite High
antidepressant 1 67.28 Quite High
Nicotine 3 13.36 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 8 99.30 Very High Very High Very High
Poisoning 8 98.56 Very High Very High Very High
Stress 49 97.24 Very High Very High Very High
Death 2 93.52 High High
Injury 22 81.76 Quite High
Middle Cerebral Artery Infarction 1 67.36 Quite High
Toxicity 2 66.92 Quite High
Cancer 14 58.08 Quite High
Nicotine Addiction 16 46.52 Quite Low
Disease 16 25.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed.
Positive_regulation (increase) of GSH-Px in liver
1) Confidence 0.37 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities.
Positive_regulation (increased) of GSH-Px
2) Confidence 0.37 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities.
Positive_regulation (consequence) of GSH-Px
3) Confidence 0.27 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed.
Positive_regulation (increase) of GSH-Px in liver
4) Confidence 0.27 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of GSH-Px
5) Confidence 0.25 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.17
Pretreatment with NT before acetaminophen decreased the contents of GSH further but increased the contents of GSSG and total glutathione and enhanced the activity of GSH-Px.
Positive_regulation (enhanced) of GSH-Px associated with paracetamol
6) Confidence 0.23 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7973799 Disease Relevance 0.14 Pain Relevance 0.49
These results indicated that NT may enhance synthesis of glutathione and the ability for hepatocytes to scavenge free radicals by increasing the activity of GSH-Px accompanied by oxidation of GSH to GSSG.
Positive_regulation (increasing) of GSH-Px in hepatocytes
7) Confidence 0.15 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7973799 Disease Relevance 0.14 Pain Relevance 0.45
Treatment with TFA (160, 80, and 40 mg/kg) significantly ameliorated mice escape-directed behavioral impairment induced by PSD, markedly reduced MDA levels, and increased the activity of SOD, GSH-Px close to normal levels.
Positive_regulation (increased) of GSH-Px associated with depression
8) Confidence 0.07 Published 2009 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 19248161 Disease Relevance 0.99 Pain Relevance 0.45
Twenty-four hours after Cd intoxication an increased lipid peroxidation (p<0.05), depleted GSH level (p<0.01), increased activity of GSH-Px (p<0.05) and inhibited CAT activity (p<0.01) were found in Cd-treated group compared to controls.
Positive_regulation (increased) of GSH-Px associated with poisoning
9) Confidence 0.06 Published 2010 Journal Interdisciplinary Toxicology Section Abstract Doc Link PMC2984133 Disease Relevance 0.41 Pain Relevance 0
CS inhalation induced catalase, GSH-Px and GR activities without affecting the SOD activity in the smoked group as well as AT + smoked group.
Positive_regulation (induced) of GSH-Px
10) Confidence 0.06 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0 Pain Relevance 0
Effects of the high dosage of marine drug on the changes were also observed, but the results were diverse, as the medicine changed significantly activities of CAT and GSH-Px (P<0.01) as well as content of MDA (P<0.05), and did not alter the activity of SOD (P>0.05).
Positive_regulation (changed) of GSH-Px
11) Confidence 0.06 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666885 Disease Relevance 0.06 Pain Relevance 0
We also observed that the other antioxidant enzymes like catalase, GSH-Px, and GR increased significantly in both the smoked as well as AT + smoked groups after 4, 6 and 8 weeks of CS exposure but still could not prevent the increase in LPO levels.
Positive_regulation (increased) of GSH-Px
12) Confidence 0.05 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.37 Pain Relevance 0
There was a significant increase in the activities of catalase, glutathione peroxidase (GSH-Px) and GR observed in all the groups exposed to CS for 4,6 or 8 weeks.
Positive_regulation (increase) of GSH-Px
13) Confidence 0.05 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.14 Pain Relevance 0

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