INT55091

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 10.77
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Anatomy Link Frequency
liver 7
kidney 2
1A2 1
reticulum 1
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 84 99.66 Very High Very High Very High
Inflammation 73 94.56 High High
Bile 40 92.64 High High
Glutamate 9 84.92 Quite High
depression 4 84.44 Quite High
Morphine 6 82.64 Quite High
Opioid 2 81.44 Quite High
ischemia 5 81.20 Quite High
Angina 1 72.04 Quite High
Pain 6 67.64 Quite High
Disease Link Frequency Relevance Heat
Aging 163 99.92 Very High Very High Very High
Stress 149 99.92 Very High Very High Very High
Diabetes Mellitus 77 99.84 Very High Very High Very High
Toxicity 36 99.48 Very High Very High Very High
Poisoning 32 99.44 Very High Very High Very High
Hepatotoxicity 53 99.00 Very High Very High Very High
Lymphatic System Cancer 6 98.88 Very High Very High Very High
Body Weight 41 98.20 Very High Very High Very High
Colon Cancer 6 94.60 High High
INFLAMMATION 71 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol (acetaminophen) 90-150 mg.kg-1 increased the activity of serum glutathione S-transferase (GST) and yet reduced the activities of liver microsomal and homogenate GST in mice.
Positive_regulation (increased) of GST in liver associated with paracetamol
1) Confidence 0.69 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 8010073 Disease Relevance 0 Pain Relevance 0.47
The hepatic GST activity and protein levels of alpha class (Ya, Yc) and mu class (Yb1, Yb2) of GST were elevated in a dose-dependent manner after treatment with PEITC (0, 3.16, 10, 31.6, 100 and 200 mg/kg, p.o., 3 days).
Positive_regulation (elevated) of GST
2) Confidence 0.69 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.22 Pain Relevance 0.37
The hepatic GST activity and protein levels of alpha class (Ya, Yc) and mu class (Yb1, Yb2) of GST were elevated in a dose-dependent manner after treatment with PEITC (0, 3.16, 10, 31.6, 100 and 200 mg/kg, p.o., 3 days).
Positive_regulation (elevated) of GST
3) Confidence 0.69 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.22 Pain Relevance 0.38
We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities.
Positive_regulation (increased) of GST enzyme
4) Confidence 0.64 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed.
Positive_regulation (increase) of GST in liver
5) Confidence 0.64 Published 1994 Journal J Appl Toxicol Section Abstract Doc Link 7963244 Disease Relevance 0 Pain Relevance 0.16
For conjugation activities, methanol extract elevated UGT and GST activities.
Positive_regulation (elevated) of GST
6) Confidence 0.60 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.13 Pain Relevance 0.06
Induction of GST subunits was detected in the liver of Gstz1(-/-) mice by Western blotting with specific antisera and high-performance liquid chromatography analysis of glutathione affinity column-purified proteins.
Positive_regulation (Induction) of GST in liver
7) Confidence 0.54 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16278372 Disease Relevance 0.13 Pain Relevance 0.04
This toxicity may be attributed to the increased GST activity or the decreased hepatic concentrations of glutathione, or both.
Positive_regulation (increased) of GST associated with toxicity
8) Confidence 0.54 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16278372 Disease Relevance 0.44 Pain Relevance 0.13
A single dose of the prodrugs alone had no effect on hepatic drug metabolizing enzymes [glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase (QOR), UDP-glucuronosyltransferase (UGT), and cytochrome P450], but, concordant with the reduction of hepatotoxicity, the latentiated forms prevented the significant elevation in QOR activity and mRNA and GST mRNA elicited by acetaminophen itself.
Positive_regulation (elevation) of GST associated with paracetamol and hepatotoxicity
9) Confidence 0.52 Published 1998 Journal Chem. Res. Toxicol. Section Abstract Doc Link 9815187 Disease Relevance 0.38 Pain Relevance 0.47
Hepatic GSH levels and GST activity were increased by treatment with AC alone.
Positive_regulation (increased) of GST
10) Confidence 0.48 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.47 Pain Relevance 0.10
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Positive_regulation (increased) of GST
11) Confidence 0.47 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.23 Pain Relevance 0.44
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Positive_regulation (increased) of GST
12) Confidence 0.41 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.23 Pain Relevance 0.44
Among the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) levels were restored to almost normal levels compared with the control group.
Positive_regulation (restored) of GST
13) Confidence 0.40 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.31 Pain Relevance 0.43
Elevated GST activities in the livers of Gstz1(-/-) mice suggest that GSTZ1-1 deficiency may alter the metabolism of some drugs and xenobiotics.
Positive_regulation (Elevated) of GST in livers
14) Confidence 0.37 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16278372 Disease Relevance 0.43 Pain Relevance 0.13
GST activities were also marginally increased in both animals.
Positive_regulation (increased) of GST
15) Confidence 0.32 Published 2005 Journal Afr J Med Med Sci Section Abstract Doc Link 15971552 Disease Relevance 0 Pain Relevance 0.37
GST was similarly increased to a maximum at 6 h and the level also returned to normal after 24 h.
Positive_regulation (increased) of GST
16) Confidence 0.32 Published 2005 Journal Afr J Med Med Sci Section Abstract Doc Link 15971552 Disease Relevance 0 Pain Relevance 0.33
A prolonged paracetamol challenge (0.6% diet for 10 days) elevated liver cytosolic GSH-S-transferase activity (GST) two-fold and decreased liver GSH to 46% of control values.
Positive_regulation (elevated) of GST in liver associated with paracetamol
17) Confidence 0.32 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8237062 Disease Relevance 0 Pain Relevance 0.45
In rats, PP (50 and 100 mg/kg, p.o.) decreased the activity of P4502E1, but significantly increased the activities of GST and PST.
Positive_regulation (increased) of GST
18) Confidence 0.32 Published 2003 Journal Phytother Res Section Abstract Doc Link 12672155 Disease Relevance 0.31 Pain Relevance 0.14
GST activity is significantly increased in dwarf kidney compared with age-matched wild-type mice, certainly contributing to overall stress resistance (Figure 1).
Positive_regulation (increased) of GST in kidney associated with stress
19) Confidence 0.29 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.38 Pain Relevance 0
Administration of the protein restored the activities of intracellular antioxidant enzymes SOD, CAT, GR and GST.
Positive_regulation (restored) of GST
20) Confidence 0.29 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.83 Pain Relevance 0

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