INT55093

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 15.11
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
Anatomy Link Frequency
liver 2
inferior 1
SPINK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 401 99.76 Very High Very High Very High
fibrosis 55 98.84 Very High Very High Very High
Inflammation 41 87.20 High High
Bile 25 71.84 Quite High
Pain 26 58.24 Quite High
cytokine 9 39.44 Quite Low
Pain management 12 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 589 99.76 Very High Very High Very High
Cancer 94 99.60 Very High Very High Very High
Cystic Fibrosis 51 98.84 Very High Very High Very High
Colon Cancer 102 97.60 Very High Very High Very High
Disease 183 96.12 Very High Very High Very High
Genetic Predisposition To Disease 1 94.84 High High
Metastasis 27 94.16 High High
Pancreatic Cancer 71 92.48 High High
Protein-energy Malnutrition 1 91.92 High High
Diabetes Mellitus 34 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently an association was identified between idiopathic pancreatitis in the USA and Europe and mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene (previously termed pancreatic secretory trypsin inhibitor, PSTI).
Negative_regulation (inhibitor) of PSTI associated with pancreatitis
1) Confidence 0.42 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120202 Disease Relevance 0.85 Pain Relevance 0.08
SPINK1 is a potent protease inhibitor thought to be a specific inactivation factor of intrapancreatic trypsin activity.
Negative_regulation (inactivation) of SPINK1
2) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.32 Pain Relevance 0.67
Witt and colleagues described at first an association between mutations of the serine protease inhibitor, Kazal type 1 (SPINK1) and chronic pancreatitis [14].
Negative_regulation (inhibitor) of SPINK1 associated with chronic pancreatitis
3) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.25 Pain Relevance 0.58
SPINK1 is a potent protease inhibitor thought to be a specific inactivation factor of intrapancreatic trypsin activity.
Negative_regulation (inhibitor) of SPINK1
4) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.27 Pain Relevance 0.62
Witt and colleagues described at first an association between mutations of the serine protease inhibitor, Kazal type 1 (SPINK1) and chronic pancreatitis [14].
Negative_regulation (inhibitor) of Kazal type 1 associated with chronic pancreatitis
5) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.25 Pain Relevance 0.58
In a previous study by our group, we found that a high expression of tumour-associated trypsin inhibitor (TATI; synonymous to pancreatic secretory trypsin inhibitor, PSTI, and serine protease inhibitor Kazal type 1, SPINK1) in tumour tissue (t-TATI) was associated with an increased risk of metachronous liver metastasis and an impaired prognosis in CRC patients [3].
Negative_regulation (inhibitor) of TATI in liver associated with cancer, colon cancer and metastasis
6) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.30 Pain Relevance 0
In a previous study by our group, we found that a high expression of tumour-associated trypsin inhibitor (TATI; synonymous to pancreatic secretory trypsin inhibitor, PSTI, and serine protease inhibitor Kazal type 1, SPINK1) in tumour tissue (t-TATI) was associated with an increased risk of metachronous liver metastasis and an impaired prognosis in CRC patients [3].
Negative_regulation (inhibitor) of TATI in liver associated with cancer, colon cancer and metastasis
7) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.28 Pain Relevance 0
As high age is associated with a poor DFS and OS in CRC, and also with an impaired renal function, this relationship could to some extent contribute to the adverse prognostic impact of high s-TATI levels.
Negative_regulation (impact) of s-TATI associated with colon cancer
8) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.91 Pain Relevance 0.04
The results suggest that the diagnostic value of TATI is inferior to that of the established markers, but because of its different nature, it may be of help when used in combination as a complementary serum tumour marker in the diagnosis of pancreatic cancer.
Negative_regulation (value) of TATI in inferior associated with cancer and pancreatic cancer
9) Confidence 0.24 Published 1994 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8207049 Disease Relevance 1.26 Pain Relevance 0.17
CONCLUSIONS: PRSS1 defects seem to be causative for pancreatitis, whereas defects in SPINK1 are suggested to be associated with the disease.
Negative_regulation (defects) of SPINK1
10) Confidence 0.24 Published 2006 Journal J. Pediatr. Gastroenterol. Nutr. Section Body Doc Link 16954950 Disease Relevance 0.11 Pain Relevance 0
Mutations of SPINK1, the main intraacinar trypsin inhibitor, are associated to idiopathic [23], alcolholic [24] and the tropical form [25] of chronic pancreatitis.
Negative_regulation (inhibitor) of SPINK1 associated with chronic pancreatitis
11) Confidence 0.18 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 1.27 Pain Relevance 0.40
Human pancreatic secretory trypsin inhibitor in the assessment of the severity of acute pancreatitis.
Negative_regulation (inhibitor) of pancreatic secretory trypsin inhibitor associated with pancreatitis
12) Confidence 0.10 Published 1994 Journal J. Clin. Gastroenterol. Section Title Doc Link 7963355 Disease Relevance 0.77 Pain Relevance 0.06
Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene.
Negative_regulation (inhibitor) of pancreatic secretory trypsin inhibitor associated with fibrosis, cystic fibrosis and chronic pancreatitis
13) Confidence 0.10 Published 2003 Journal Can. J. Gastroenterol. Section Abstract Doc Link 12560855 Disease Relevance 0.64 Pain Relevance 0.30
In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP.
Negative_regulation (inhibitor) of Kazal type 1 associated with pancreatitis
14) Confidence 0.01 Published 2002 Journal Gastroenterology Section Abstract Doc Link 12360463 Disease Relevance 0.96 Pain Relevance 0.09
Mutations in the gene encoding for the pancreatic secretory trypsin inhibitor or serine protease inhibitor, Kazal type I (SPINK1) have been associated with different entities of chronic pancreatitis.
Negative_regulation (inhibitor) of Kazal type I associated with chronic pancreatitis
15) Confidence 0.00 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120224 Disease Relevance 0.68 Pain Relevance 0.21

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