INT5510

Context Info Confidence 0.43 First Reported 1986 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 1.05 Pain Relevance 2.61

extracellular space (Crh) extracellular region (Crh) response to stress (Crh) cytoplasm (Crh)

Anatomy Link Frequency hypothalamus 6 bowel 2 frontal cortex 2 Crh (Rattus norvegicus)

Pain Link Frequency Relevance Heat dexamethasone 2 99.78 Enkephalin 2 99.76 narcan 7 99.52 fluoxetine 6 98.64 Kinase C inhibitor 1 98.52 Morphine 2 98.36 Opioid 3 95.28 Locus ceruleus 2 95.20 amygdala 8 94.72 antagonist 4 93.96

Disease Link Frequency Relevance Heat Hypoglycemia 5 99.20 Depression 3 79.12 Arthritis 1 76.24 Nociception 2 75.00 Urological Neuroanatomy 2 74.12 Pain 5 56.60 Anxiety Disorder 2 51.68 Stress 1 37.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The decrease in pain behavior and BDNF-IR, CRF mRNA levels in frontal cortex of arthritic rats due to Cor were partly prevented by adrenalectomy (ADX).

Negative_regulation (prevented) of Negative_regulation (decrease) of CRF mRNA in frontal cortex

1) Confidence 0.43 Published 2000 Journal Acta Pharmacol. Sin. Section Body Doc Link 11360665 Disease Relevance 0.15 Pain Relevance 0

The inhibition of CRF release was associated with a rise in the tissue content of the hormone and was not blocked readily by naloxone.

Negative_regulation (blocked) of Negative_regulation (inhibition) of CRF associated with narcan

2) Confidence 0.42 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2936971 Disease Relevance 0 Pain Relevance 0.49

Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.

Negative_regulation (decreased) of Negative_regulation (decreased) of CRH in hypothalamus associated with locus ceruleus and fluoxetine

3) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.41

Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.

Negative_regulation (decreased) of Negative_regulation (decreased) of corticotropin-releasing hormone in hypothalamus associated with locus ceruleus and fluoxetine

4) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.41

Either chlorisondamine, naloxone, or vagotomy--but not bretylium--reversed the inhibitory effect of central CRF on small bowel transit.

Negative_regulation (reversed) of Negative_regulation (effect) of CRF in bowel associated with narcan

5) Confidence 0.38 Published 1988 Journal Gastroenterology Section Abstract Doc Link 3257450 Disease Relevance 0 Pain Relevance 0.35

Inhibitory effects of CRF (10 microM) were reversed by astressin-2B.

Negative_regulation (reversed) of Negative_regulation (effects) of CRF

6) Confidence 0.37 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18171711 Disease Relevance 0.30 Pain Relevance 0.53

Hypoglycemia-induced POMC mRNA levels in the AP and CRF mRNA levels in the hypothalamus were also dose-dependently inhibited by the administration of EP.

Negative_regulation (inhibited) of Negative_regulation (inhibited) of CRF mRNA in hypothalamus associated with hypoglycemia

7) Confidence 0.32 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.44 Pain Relevance 0.16

Dexamethasone treatment prevents the inhibitory effect of corticotropin-releasing hormone on gonadotropin release in the primate.

Negative_regulation (prevents) of Negative_regulation (effect) of corticotropin-releasing hormone associated with dexamethasone

8) Confidence 0.09 Published 1989 Journal Neuroendocrinology Section Title Doc Link 2498756 Disease Relevance 0 Pain Relevance 0.27

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