INT55106

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.81
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sub1) nucleus (Sub1) DNA binding (Sub1)
Anatomy Link Frequency
neurons 3
IB4 1
vessels 1
Sub1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 97.32 Very High Very High Very High
medulla 1 97.12 Very High Very High Very High
antagonist 1 96.56 Very High Very High Very High
Sciatic nerve 1 96.28 Very High Very High Very High
Pain 12 96.16 Very High Very High Very High
substance P 2 94.96 High High
Spinal cord 4 92.88 High High
noradrenaline 1 91.84 High High
spinal dorsal horn 2 90.00 High High
Inflammation 30 88.40 High High
Disease Link Frequency Relevance Heat
Pain 15 96.16 Very High Very High Very High
Fever 1 94.96 High High
Apoptosis 6 94.72 High High
Cancer 4 92.32 High High
Shock 1 92.04 High High
Nociception 7 90.76 High High
INFLAMMATION 34 87.80 High High
Stress 9 87.44 High High
Ganglion Cysts 28 87.28 High High
Frailty 1 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bath application of Sub-P induced an inward current (I(Sub-P)) in NAergic neurons, which was significantly blocked by Neurokinin 1 (NK1) receptor antagonist.
Positive_regulation (induced) of Sub-P in neurons associated with antagonist
1) Confidence 0.20 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19463951 Disease Relevance 0.09 Pain Relevance 0.28
CFA evoked a 34% increase in the number of Y1 mRNA-positive neurons in ipsilateral DRGs as compared to contralateral DRGs.
Positive_regulation (increase) of Y1 mRNA-positive in neurons
2) Confidence 0.05 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965047 Disease Relevance 0.14 Pain Relevance 0.51
Twenty-four hours and 7 days after injection, many inducible nitric oxide synthase-positive cells and a high level of nitrite were detected at the injection site.
Positive_regulation (inducible) of synthase-positive
3) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886331 Disease Relevance 0.51 Pain Relevance 0.19
Seven days of nimesulide (10 mg/kg/day, i.m.) treatment strongly attenuated the microglial reaction, reduced the number of inducible nitric oxide synthase-positive cells and completely abolished the increase in prostaglandin-E2 formation.
Positive_regulation (inducible) of synthase-positive
4) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886331 Disease Relevance 0.28 Pain Relevance 0.10
However, that study did not divide cells into IB4-positive and IB4-negative cells, yet still showed over 2 fold increases in magnitude of the faster inactivating component, whereas in the present study a similar increase was observed in IB4-negative cells with no increase in IB4-positive cells.
Neg (no) Positive_regulation (increase) of IB4-positive in IB4
5) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0.26 Pain Relevance 0.13
Immunohistochemistry showed increased numbers of active caspase-3-, HSP70-, and HSP27-positive neurons.
Positive_regulation (increased) of HSP27-positive in neurons
6) Confidence 0.02 Published 2005 Journal Diabetes Section Abstract Doc Link 16249457 Disease Relevance 1.36 Pain Relevance 0.56
Trpv4 expression as well as Ki67-positive staining was significantly increased in collateral vessels.
Positive_regulation (increased) of Ki67-positive in vessels
7) Confidence 0.01 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.49 Pain Relevance 0.06
Laboratory data showed leucocytosis, mild elevation of aspartate aminotransferase, alanine aminotransferase and sugar, positive-HBsAg, and normal range CEA and AFP.
Positive_regulation (elevation) of positive-HBsAg
8) Confidence 0.01 Published 1993 Journal Changgeng Yi Xue Za Zhi Section Abstract Doc Link 8387867 Disease Relevance 0.67 Pain Relevance 0.10

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