INT5511

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 47
Total Number 48
Disease Relevance 12.08
Pain Relevance 23.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 9
ARC 7
pituitary 6
medial 4
forebrain 4
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 59 100.00 Very High Very High Very High
antagonist 56 100.00 Very High Very High Very High
Enkephalin 52 100.00 Very High Very High Very High
Dopamine 28 100.00 Very High Very High Very High
midbrain 17 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
depression 6 100.00 Very High Very High Very High
Nicotine 40 99.98 Very High Very High Very High
narcan 39 99.98 Very High Very High Very High
agonist 31 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 62 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 7 100.00 Very High Very High Very High
Respiratory Failure 1 100.00 Very High Very High Very High
Starvation 15 99.90 Very High Very High Very High
Diabetes Mellitus 19 99.84 Very High Very High Very High
Hypoglycemia 7 99.82 Very High Very High Very High
Anorexia 6 99.80 Very High Very High Very High
Hyperalgesia 2 99.68 Very High Very High Very High
Cancer 31 99.52 Very High Very High Very High
Hyperglycemia 2 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, there was a 30-40% decline in the number of cells expressing POMC mRNA in middle-aged and old animals, suggesting an overall age-related decline in POMC gene expression in middle-aged and old animals independent of reproductive status.
Negative_regulation (decline) of Gene_expression (expression) of POMC gene
1) Confidence 0.59 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0 Pain Relevance 0.06
Thus, moderate-dosage nocturnal melatonin supplementation suppressed nocturnal hypothalamic POMC gene expression in both middle-aged males and females, suggesting that melatonin supplementation during aging decreases, rather than increases, forebrain opiomelanocortinergic activity.
Negative_regulation (suppressed) of Gene_expression (expression) of POMC gene in forebrain associated with aging
2) Confidence 0.59 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12562504 Disease Relevance 0.22 Pain Relevance 0
All antidepressants, but not saline, cocaine and haloperidol, reduced POMC mRNA expression.
Negative_regulation (reduced) of Gene_expression (expression) of POMC mRNA associated with antidepressant and cocaine
3) Confidence 0.58 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679057 Disease Relevance 0.54 Pain Relevance 0.42
In conclusion, antidepressant treatments decrease basal POMC mRNA expression without affecting the acute stress response, and the reduced POMC mRNA may be related to reduced 5-HT(1A)-stimulated hypothalamic output.
Negative_regulation (decrease) of Gene_expression (expression) of POMC mRNA associated with stress and antidepressant
4) Confidence 0.58 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679057 Disease Relevance 0.56 Pain Relevance 0.35
Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: effects of acute stress and 5-HT(1A) receptor activation.
Negative_regulation (decrease) of Gene_expression (expression) of pro-opiomelanocortin mRNA in pituitary gland associated with stress and antidepressant
5) Confidence 0.58 Published 2001 Journal J. Neuroendocrinol. Section Title Doc Link 11679057 Disease Relevance 0.46 Pain Relevance 0.35
Age-related decrease in proopiomelanocortin gene expression in the arcuate nucleus of the male rat brain.
Negative_regulation (decrease) of Gene_expression (expression) of proopiomelanocortin gene in arcuate nucleus
6) Confidence 0.58 Published 1991 Journal Neurobiol. Aging Section Title Doc Link 1711159 Disease Relevance 0.25 Pain Relevance 0.09
Therefore, correction of hyperglycemia in STZ-diabetic rats could reverse the higher gene expression of POMC in the adrenal gland.
Negative_regulation (reverse) of Gene_expression (expression) of POMC in adrenal gland associated with hyperglycemia and diabetes mellitus
7) Confidence 0.57 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.81 Pain Relevance 0.11
In contrast, the synthetic mu-agonist loperamide significantly inhibited basal and yet enhanced cAMP-induced POMC expression.
Negative_regulation (inhibited) of Gene_expression (expression) of POMC associated with agonist
8) Confidence 0.57 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474216 Disease Relevance 0 Pain Relevance 0.95
Analysis of beta-endorphin-related peptides on sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that chronic ethanol treatment reduced the in vitro biosynthesis of the beta-endorphin precursor pro-opiomelanocortin.
Negative_regulation (reduced) of Gene_expression (biosynthesis) of beta-endorphin precursor pro-opiomelanocortin
9) Confidence 0.51 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6086835 Disease Relevance 0 Pain Relevance 0.08
Intraperitoneal injections of various doses of doxycycline were made to elucidate the possible exogenous downregulation of transfected beta-endorphin gene expression in vivo.
Spec (possible) Negative_regulation (downregulation) of Gene_expression (expression) of beta-endorphin gene
10) Confidence 0.51 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15116065 Disease Relevance 0.52 Pain Relevance 0.91
These results suggest that chronic nicotine inhibited POMC gene expression and thus, probably, biosynthesis of beta-endorphin and other opiomelanocortins.
Negative_regulation (inhibited) of Gene_expression (expression) of POMC gene associated with nicotine
11) Confidence 0.49 Published 1998 Journal Psychoneuroendocrinology Section Abstract Doc Link 9695129 Disease Relevance 0.07 Pain Relevance 0.72
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Negative_regulation (Down-regulation) of Gene_expression (synthesis) of beta-endorphin in hypothalamus associated with enkephalin and morphine
12) Confidence 0.43 Published 1989 Journal J. Mol. Neurosci. Section Title Doc Link 2534967 Disease Relevance 0.07 Pain Relevance 1.01
The concomitant administration of morphine and naloxone completely prevented the effect of morphine on POMC gene expression indicating that the inhibitory influence of morphine is likely to be mediated by opioid receptors.
Negative_regulation (prevented) of Gene_expression (expression) of POMC gene associated with narcan, opioid receptor and morphine
13) Confidence 0.43 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8413862 Disease Relevance 0 Pain Relevance 1.28
The levels of beta-endorphin in midbrain, hypothalamus, and pituitary of morphine tolerant-dependent rats were decreased significantly.
Negative_regulation (decreased) of Gene_expression (levels) of beta-endorphin in pituitary associated with midbrain and morphine
14) Confidence 0.43 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.47
The development of POMC gene expression in the medial basal hypothalamus of prepubertal rats.
Negative_regulation (development) of Gene_expression (expression) of POMC gene in medial
15) Confidence 0.43 Published 1999 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 10446343 Disease Relevance 0 Pain Relevance 0.18
In vitro exposure of hypothalamic and striatal dopaminergic nerve terminals to a wide range of concentrations of beta-endorphin failed to reproduce the in vivo results; some concentrations of beta-endorphin produced small decreases in [3H]dopamine uptake which were not reversed by naloxone.
Neg (not) Negative_regulation (reversed) of Gene_expression (produced) of beta-endorphin in nerve associated with dopamine and narcan
16) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6291701 Disease Relevance 0 Pain Relevance 0.76
CONCLUSIONS: The POMC gene can be transferred in the bladder using the gene gun and increased bladder expression of endorphin can suppress nociceptive responses induced by bladder irritation.
Negative_regulation (suppress) of Gene_expression (expression) of endorphin in bladder
17) Confidence 0.43 Published 2003 Journal J. Urol. Section Body Doc Link 14532850 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To examine the efficacy of POMC gene transfer with RSW, efficiency of beta-endorphin production in transfected cells, and its effects and side effects in pain models.
Negative_regulation (efficiency) of Gene_expression (production) of beta-endorphin
18) Confidence 0.43 Published 2009 Journal Spine Section Body Doc Link 19934807 Disease Relevance 0.19 Pain Relevance 0
In addition, naloxone blocked the impairment produced by beta-endorphin.
Negative_regulation (blocked) of Gene_expression (produced) of beta-endorphin associated with narcan
19) Confidence 0.43 Published 1983 Journal Behav. Neural Biol. Section Abstract Doc Link 6322740 Disease Relevance 0.51 Pain Relevance 0.41
We hypothesize that suppression of forebrain beta-endorphin synthesis in response to long-term nicotine exposure produces a chronically opioid deficient condition which may play an important role in maintaining nicotine self-administration and in mediating some changes during the nicotine withdrawal syndrome.
Negative_regulation (suppression) of Gene_expression (synthesis) of beta-endorphin in forebrain associated with nicotine, withdrawal and opioid
20) Confidence 0.43 Published 1998 Journal Psychoneuroendocrinology Section Abstract Doc Link 9695129 Disease Relevance 0.15 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox