INT55113

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Context Info
Confidence 0.29
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.92
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
CRS (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 4 99.08 Very High Very High Very High
Opioid 2 96.84 Very High Very High Very High
Inflammatory response 2 96.80 Very High Very High Very High
hypoalgesia 3 95.88 Very High Very High Very High
aspirin 64 95.12 Very High Very High Very High
adenocard 28 91.92 High High
cytokine 8 88.88 High High
Central grey 5 75.00 Quite High
Antinociceptive 3 75.00 Quite High
Rostral ventromedial medulla 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Chronic Sinusitis 174 100.00 Very High Very High Very High
Syndrome 100 100.00 Very High Very High Very High
Eosinophilia 50 100.00 Very High Very High Very High
Pressure And Volume Under Development 14 100.00 Very High Very High Very High
Rhinitis 136 99.98 Very High Very High Very High
Shock 5 99.98 Very High Very High Very High
Hypersensitivity 36 99.68 Very High Very High Very High
Polyps 44 98.78 Very High Very High Very High
INFLAMMATION 14 96.80 Very High Very High Very High
Hypoalagesia 3 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The percentage of CRs was on average 74.0?
Positive_regulation (percentage) of Gene_expression (percentage) of CRs
1) Confidence 0.29 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2996171 Disease Relevance 0 Pain Relevance 0
In CRS, there is no balance between NO and ROS because of the increased production of the latter.
Positive_regulation (increased) of Gene_expression (production) of CRS associated with syndrome
2) Confidence 0.29 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 0.91 Pain Relevance 0.13
Arginine vasopressin (AVP) has also detrimental effects on CRS progression by fluid retention and enhancement of angiotensin II and noradrenaline actions.
Positive_regulation (enhancement) of Gene_expression (progression) of CRS associated with pressure and volume under development, syndrome and noradrenaline
3) Confidence 0.29 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.23 Pain Relevance 0.32
This suggested that unknown nonallergic mechanism(s) contributed to both eosinophilia and higher IgE levels in CRS.


Positive_regulation (contributed) of Gene_expression (levels) of CRS associated with chronic sinusitis and eosinophilia
4) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 0.74 Pain Relevance 0
This suggested that mechanism(s) responsible for polyp formation predominated in NPasa and NPother, but that atopy modified the expression of CRS in the allergic NPother subset.
Positive_regulation (modified) of Gene_expression (expression) of CRS associated with rhinitis, chronic sinusitis, hypersensitivity and polyps
5) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 1.50 Pain Relevance 0.40
The presentation of an auditory stimulus that signals a noxious event such as foot shock results in the simultaneous expression of multiple aversive conditional responses (CRs), which include a transient elevation of arterial blood pressure (ABP) and an opioid-mediated form of hypoalgesia.
Positive_regulation (results) of Gene_expression (expression) of CRs in blood associated with shock, hypoalgesia and opioid
6) Confidence 0.06 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965101 Disease Relevance 0.54 Pain Relevance 0.39

General Comments

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