INT5512

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 7.33
Pain Relevance 9.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
hypothalamus 3
blood 3
NK cell 2
plasma 1
PVH 1
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 26 99.84 Very High Very High Very High
dexamethasone 3 99.84 Very High Very High Very High
Potency 7 99.82 Very High Very High Very High
Acupuncture 9 99.70 Very High Very High Very High
fluoxetine 2 99.70 Very High Very High Very High
midbrain 3 99.64 Very High Very High Very High
Opioid 22 99.58 Very High Very High Very High
allodynia 4 99.52 Very High Very High Very High
opioid receptor 9 99.28 Very High Very High Very High
Periaqueductal grey 8 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 32 99.96 Very High Very High Very High
Neuropathic Pain 16 99.52 Very High Very High Very High
Urological Neuroanatomy 15 99.28 Very High Very High Very High
Infection 116 98.44 Very High Very High Very High
Hypoglycemia 15 98.20 Very High Very High Very High
Weight Loss 7 98.06 Very High Very High Very High
Nociception 19 97.76 Very High Very High Very High
Influenza Virus Infection 92 97.24 Very High Very High Very High
Death 17 95.80 Very High Very High Very High
Targeted Disruption 21 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In adrenalectomized rats, fluoxetine significantly decreased beta-Ep levels in the hypothalamus and increased the levels in the PAG.
Negative_regulation (decreased) of beta-Ep in hypothalamus associated with central grey and fluoxetine
1) Confidence 0.36 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3010328 Disease Relevance 0.44 Pain Relevance 0.44
Thus, the data indicate that the aversive properties of naloxone are attenuated by disruption of central (but not peripheral) beta-EP activity.
Negative_regulation (disruption) of beta-EP associated with narcan
2) Confidence 0.33 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2863837 Disease Relevance 0 Pain Relevance 0.57
In contrast to the effect of the lesions, suppression of circulating beta-EP by dexamethasone treatment failed to influence conditioning produced by naloxone.
Negative_regulation (suppression) of beta-EP associated with narcan and dexamethasone
3) Confidence 0.33 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2863837 Disease Relevance 0 Pain Relevance 0.58
In contrast, Nav 1.8 AS ODN failed to reduce mechanical allodynia in the vincristine chemotherapy-induced neuropathic pain model or a skin-incision model of post-operative pain.
Neg (failed) Negative_regulation (reduce) of ODN in skin associated with pain, vincristine, allodynia and neuropathic pain
4) Confidence 0.33 Published 2006 Journal Pain Section Abstract Doc Link 16545521 Disease Relevance 1.03 Pain Relevance 1.20
The integral optical density (IOD) and mean optical density (OD) of the stained sections were measured with a computer-assisted image-processing and analytical system. beta-Ep immunoreactivity was much decreased in the sections treated with melatonin and the IOD and OD were also decreased significantly (P<0.01; P<0.05).
Negative_regulation (decreased) of beta-Ep
5) Confidence 0.28 Published 2000 Journal Sheng Li Xue Bao Section Abstract Doc Link 11956578 Disease Relevance 0 Pain Relevance 0.16
AS-ODN and ODN control oligonucleotides were mixed with 1 ml of aCSF at 122 ?
Negative_regulation (oligonucleotides) of ODN
6) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0
AS-ODN and ODN control oligonucleotides were mixed with 1 ml of aCSF at 122 ?
Negative_regulation (oligonucleotides) of ODN
7) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0
The inhibitory effect of EP was reversed by naloxone.
Negative_regulation (reversed) of EP associated with narcan
8) Confidence 0.25 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.43 Pain Relevance 0.16
The inhibitory effect of EP was reversed by naloxone.
Negative_regulation (effect) of EP associated with narcan
9) Confidence 0.25 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.43 Pain Relevance 0.16
These results suggest that 1) central administration of EP acts through the opioid receptor to inhibit hypoglycemia-induced CRF gene expression in the hypothalamus and CRF release, which results in a decrease in ACTH secretion and POMC mRNA levels in the AP; and 2) the active site of EP is the CRF neuron in the paraventricular nucleus.
Negative_regulation (administration) of EP in hypothalamus associated with hypoglycemia and opioid receptor
10) Confidence 0.24 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.43 Pain Relevance 0.16
The in vitro NK cell response to beta-EP was reduced in the splenocytes obtained from animals treated with ethanol for 2 wk, but not in those obtained from animals treated with ethanol for 1 wk as compared with those in control animals.
Negative_regulation (reduced) of beta-EP in NK cell
11) Confidence 0.24 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11698436 Disease Relevance 0 Pain Relevance 0.29
However, animals treated with ethanol for 2, 3, or 4 wk showed decreased hypothalamic and plasma levels of IR-beta-EP and decreased splenic NK cell activity.
Negative_regulation (decreased) of beta-EP in NK cell
12) Confidence 0.21 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11698436 Disease Relevance 0 Pain Relevance 0.18
Icv administration of NT antiserum increased splenic NKCA and decreased blood beta-EP.
Negative_regulation (decreased) of beta-EP in blood
13) Confidence 0.21 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9299063 Disease Relevance 0.13 Pain Relevance 0.19
The potency of beta h-EP was reduced in a dose-related fashion by applications of nanomolar concentrations of naloxone or N-allylnormetazocine and by micromolar concentrations of levorphanol or morphine.
Negative_regulation (reduced) of h-EP associated with narcan, morphine and potency
14) Confidence 0.18 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6123591 Disease Relevance 0 Pain Relevance 0.96
Stimulated animals displayed a pronounced decrease in levels of immunoreactive (ir)-beta-endorphin (beta-EP) in the midbrain PAG.
Negative_regulation (decrease) of beta-EP in midbrain associated with periaqueductal grey and midbrain
15) Confidence 0.18 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884014 Disease Relevance 0.42 Pain Relevance 0.75
Inhibition of the [125I]beta-EP binding by naloxone (10 microM) was approximately only 20%, and that by D-Ala2-D-Leu5-enkephalin (10 microM) was null, suggesting the major role of a non-opioid binding component in specific [125I]beta-EP binding to basolateral membranes.
Negative_regulation (Inhibition) of beta-EP associated with narcan, enkephalin and opioid
16) Confidence 0.18 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2092936 Disease Relevance 0 Pain Relevance 0.35
Pretreatment with naloxone methyl bromide (Br-naloxone), a quaternary naloxone derivative, which does not cross the blood-brain barrier, had no effect on the PRL response to beta EP but prevented the conjugated effect of beta EP and TRH on PRL secretion.
Negative_regulation (effect) of EP in blood associated with narcan
17) Confidence 0.17 Published 1987 Journal Life Sci. Section Abstract Doc Link 3104708 Disease Relevance 0 Pain Relevance 0.47
Several weeks after the ethanol treatment, we detected a reduction in the number of beta-EP neuronal perikarya in arcuate nuclei and in the number of beta-EP neuronal terminals in paraventricular nuclei of the hypothalamus in the treated rats.
Negative_regulation (reduction) of beta-EP in neuronal
18) Confidence 0.14 Published 2007 Journal Endocrinology Section Abstract Doc Link 17347308 Disease Relevance 0.46 Pain Relevance 0.11
Thus in the setting of chronic opioid antagonism although beta-EP content decreases, there is relatively more beta-EP1-31, the biologically active opioid form of the peptide, compared to the C-terminally cleaved forms of beta-EP which have reduced biological activity.
Negative_regulation (decreases) of beta-EP associated with opioid
19) Confidence 0.14 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922523 Disease Relevance 0 Pain Relevance 0.42
The inhibitory effect of beta-endorphin (EP) or other opioids on TSH secretion is, in contrast to their stimulating properties on PRL release, still a matter of debate.
Negative_regulation (effect) of EP associated with opioid
20) Confidence 0.13 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2975264 Disease Relevance 0 Pain Relevance 0.17

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