INT55123

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Context Info
Confidence 0.30
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.86
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
plasma cell 1
spike 1
B cell 1
oligodendrocytes 1
Ceacam1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.72 Very High Very High Very High
opioid receptor 1 99.50 Very High Very High Very High
Demyelination 492 98.88 Very High Very High Very High
Opioid 3 98.68 Very High Very High Very High
analgesia 3 98.40 Very High Very High Very High
Spinal cord 132 84.88 Quite High
Enkephalin 2 81.68 Quite High
Inflammation 172 78.52 Quite High
Central nervous system 140 74.84 Quite High
Multiple sclerosis 88 73.08 Quite High
Disease Link Frequency Relevance Heat
Infection 354 99.96 Very High Very High Very High
Hepatitis 28 99.68 Very High Very High Very High
Epstein-barr Virus 43 99.08 Very High Very High Very High
Demyelinating Disease 916 98.88 Very High Very High Very High
Sprains And Strains 334 94.08 High High
Viral Meningitis 56 91.12 High High
Meningitis 24 88.88 High High
INFLAMMATION 172 78.52 Quite High
Optic Neuritis 68 72.80 Quite High
Apoptosis 3 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of the systemically active irreversible opioid receptor antagonist clocinnamox (C-CAM; 14 beta-(p-chlorocinnamoylamino)-7,8-dihydro-N- cyclopropylmethyl normorphinone mesylate) on mu receptor binding to cerebral membranes and on mu opioid analgesia were assessed using mice.
C-CAM Binding (binding) of associated with antagonist, opioid receptor, opioid and analgesia
1) Confidence 0.30 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965787 Disease Relevance 0 Pain Relevance 0.86
As alteration of the MHV S protein influences pathogenesis, it is important to understand how alteration of the S protein alters the virus-host interaction.
MHV Binding (alteration) of
2) Confidence 0.19 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.50 Pain Relevance 0.23
On the other hand, neurotropic nondemyelinating MHV3 has an in vitro affinity for neurons, ependymal cells and meningothelial cells but not for astrocytes or oligodendrocytes.
MHV3 Binding (affinity) of in oligodendrocytes
3) Confidence 0.19 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 1.39 Pain Relevance 0.43
The ~1300 amino acid spike protein in MHV-A59 is usually posttranslationally cleaved into two domains which associate with each other to form a functional dimer.
MHV-A59 Binding (associate) of in spike
4) Confidence 0.16 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.98 Pain Relevance 0.42
To avoid a high mortality rate of MHV-2 due to hepatitis, 0.5?
MHV-2 Binding (rate) of associated with hepatitis
5) Confidence 0.16 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 1.45 Pain Relevance 0.50
The latter observation raises the possibility that, like EBV and KSHV, plasma cell differentiation may be associated with MHV68 reactivation.
MHV68 Binding (associated) of in plasma cell associated with epstein-barr virus
6) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.39 Pain Relevance 0
Proliferating B cells harbor the majority of latent MHV68 genomes, and splenic B cell activation is associated with MHV68 infection at the onset of latency [30],[31].
MHV68 Binding (associated) of in B cell associated with infection
7) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.17 Pain Relevance 0

General Comments

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