INT5513

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 295
Total Number 298
Disease Relevance 60.90
Pain Relevance 158.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 25
plasma 24
pituitary 21
brain 18
arcuate nucleus 16
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 367 100.00 Very High Very High Very High
Opioid 363 100.00 Very High Very High Very High
Enkephalin 307 100.00 Very High Very High Very High
narcan 268 100.00 Very High Very High Very High
antagonist 204 100.00 Very High Very High Very High
withdrawal 145 100.00 Very High Very High Very High
opiate 124 100.00 Very High Very High Very High
Dynorphin 102 100.00 Very High Very High Very High
midbrain 87 100.00 Very High Very High Very High
Neuropeptide 82 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 125 100.00 Very High Very High Very High
Aids-related Complex 68 100.00 Very High Very High Very High
Pressure And Volume Under Development 25 100.00 Very High Very High Very High
Sleep Disorders 12 100.00 Very High Very High Very High
Depression 10 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 8 100.00 Very High Very High Very High
Shock 27 99.98 Very High Very High Very High
Starvation 25 99.98 Very High Very High Very High
Hyperalgesia 91 99.96 Very High Very High Very High
Diabetes Mellitus 59 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in POMC mRNA levels in the middle-aged and old animals occurred regardless of their reproductive status prior to ovariectomy.
Negative_regulation (decrease) of POMC mRNA
1) Confidence 0.59 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0.05 Pain Relevance 0.16
POMC mRNA levels decreased 20-30% by the time animals were middle-aged, and no further decline was noted in the old animal groups.
Negative_regulation (decreased) of POMC mRNA
2) Confidence 0.59 Published 1991 Journal Endocrinology Section Abstract Doc Link 1915074 Disease Relevance 0.06 Pain Relevance 0.17
The results showed that morphine treatment induced a decrease in the incorporation of the radioactive amino acid into total protein, pro-opiomelanocortin, beta-LPH and beta-endorphin.
Negative_regulation (decrease) of beta-endorphin associated with morphine
3) Confidence 0.59 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6268419 Disease Relevance 0.07 Pain Relevance 0.46
Intraperitoneal doxycycline decreased the antinociceptive effect and spinal beta-endorphin levels in a dose-dependent manner.
Negative_regulation (decreased) of beta-endorphin in spinal associated with antinociceptive
4) Confidence 0.59 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15116065 Disease Relevance 0.51 Pain Relevance 0.93
Levels of the POMC opioid products, ACTH and beta-endorphin, were significantly reduced in splenocytes incubated with POMC antisense probes.
Negative_regulation (reduced) of beta-endorphin associated with opioid
5) Confidence 0.59 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10814777 Disease Relevance 0 Pain Relevance 0.56
Antisense inhibition of pro-opiomelanocortin and proenkephalin A messenger RNA translation alters rat immune cell function in vitro.
Negative_regulation (inhibition) of pro-opiomelanocortin in immune cell associated with enkephalin
6) Confidence 0.59 Published 2000 Journal J. Neuroimmunol. Section Title Doc Link 10814777 Disease Relevance 0 Pain Relevance 0.56
Chronic administration of morphine to rats for a period of 4 weeks resulted in a 50-60% decrease in the tissue concentrations of beta-endorphin and in the in vitro release from the neurointermediate pituitary.
Negative_regulation (decrease) of beta-endorphin in pituitary associated with morphine
7) Confidence 0.59 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6268751 Disease Relevance 0 Pain Relevance 0.17
Finally, 10 wk administration of 30 microg melatonin kg bw(-1) day(-1) suppressed (31%, P < 0.01) POMC mRNA content in middle-aged male rats killed at the end of the dark period.
Negative_regulation (suppressed) of POMC mRNA
8) Confidence 0.59 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12562504 Disease Relevance 0.21 Pain Relevance 0.06
To test whether the decline in melatonin is responsible for the decline in POMC mRNA, we investigated the effects of daily melatonin treatment on hypothalamic POMC mRNA content in middle-aged and older Sprague-Dawley rats.
Spec (whether) Negative_regulation (decline) of POMC mRNA
9) Confidence 0.59 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12562504 Disease Relevance 0.17 Pain Relevance 0.09
During protracted withdrawal beta-endorphin levels were decreased in amygdala, spinal cord and pituitary.
Negative_regulation (decreased) of beta-endorphin in spinal cord associated with amygdala, withdrawal and spinal cord
10) Confidence 0.59 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.56
These results suggest that during morphine tolerance-dependence and during protracted abstinence beta-endorphin and methionine-enkephalin levels in discrete brain regions and pituitary gland are decreased.
Negative_regulation (decreased) of beta-endorphin in pituitary gland associated with addiction, tolerance, enkephalin and morphine
11) Confidence 0.59 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.76
In addition, in naloxone-precipitated abstinence beta-endorphin levels were decreased in pituitary gland and hippocampus but increased in plasma.
Negative_regulation (decreased) of beta-endorphin in pituitary gland associated with narcan and hippocampus
12) Confidence 0.59 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.93
The levels of beta-endorphin in midbrain, hypothalamus, and pituitary of morphine tolerant-dependent rats were decreased significantly.
Negative_regulation (decreased) of beta-endorphin in pituitary associated with midbrain and morphine
13) Confidence 0.59 Published 1991 Journal Brain Res. Section Abstract Doc Link 1933285 Disease Relevance 0 Pain Relevance 1.47
We conclude that in sheep, POMC mRNA levels are not reduced at the time of the preovulatory LH surge, and reduced POMC gene transcription does not appear to be part of the neural mechanism of oestrogen positive feedback in this species.
Neg (not) Negative_regulation (reduced) of POMC mRNA in neural
14) Confidence 0.59 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.06
Proopiomelanocortin mRNA levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge.
Neg (not) Negative_regulation (reduced) of Proopiomelanocortin in hypothalamus
15) Confidence 0.59 Published 1998 Journal J. Neuroendocrinol. Section Title Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.09
Hyperprolactinemia achieved by pituitary implants also led to a significant decrease in POMC mRNA levels.
Negative_regulation (decrease) of POMC mRNA in pituitary associated with galactorrhea
16) Confidence 0.59 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475014 Disease Relevance 0.17 Pain Relevance 0.10
Depletion of central beta-endorphin blocks midbrain stimulation produced analgesia in the freely-moving rat.
Negative_regulation (Depletion) of beta-endorphin in midbrain associated with narcan, midbrain and analgesia
17) Confidence 0.59 Published 1986 Journal Neuroscience Section Title Doc Link 2944030 Disease Relevance 0.18 Pain Relevance 0.90
Bilateral, radiofrequency lesions of the mediobasal arcuate hypothalamus greatly depleted immunoreactive beta-endorphin from brain tissues without affecting its levels in plasma.
Negative_regulation (depleted) of beta-endorphin in plasma
18) Confidence 0.59 Published 1986 Journal Neuroscience Section Abstract Doc Link 2944030 Disease Relevance 0.21 Pain Relevance 1.10
Fasting associated with decrease in hypothalamic beta-endorphin.
Negative_regulation (decrease) of beta-endorphin
19) Confidence 0.59 Published 1980 Journal Science Section Title Doc Link 6254156 Disease Relevance 0 Pain Relevance 0.09
After castration, POMC mRNA content was reduced in cells of the most rostral arcuate area (intact, 152 +/- 5 grains/cell; castrate, 119 +/- 2 grains/cell; P less than 0.0005), and replacement with physiological levels of testosterone prevented the decline in POMC mRNA levels so that they remained equivalent to that of the intact animal (castrated testosterone-replaced, 153 +/- 6 grains/cell).
Negative_regulation (decline) of POMC mRNA
20) Confidence 0.58 Published 1989 Journal Endocrinology Section Abstract Doc Link 2721451 Disease Relevance 0 Pain Relevance 0

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