INT5514

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 64
Total Number 64
Disease Relevance 8.12
Pain Relevance 29.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 15
pituitary 6
anterior pituitary 3
plasma 2
nucleus 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 112 100.00 Very High Very High Very High
Serotonin 59 100.00 Very High Very High Very High
Neurotransmitter 52 100.00 Very High Very High Very High
Opioid 41 99.98 Very High Very High Very High
GABAergic 1 99.98 Very High Very High Very High
dexamethasone 15 99.92 Very High Very High Very High
opioid receptor 7 99.92 Very High Very High Very High
Clonidine 13 99.84 Very High Very High Very High
Enkephalin 35 99.80 Very High Very High Very High
gABA 58 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 301 100.00 Very High Very High Very High
Hypoglycemia 14 100.00 Very High Very High Very High
Anxiety Disorder 9 99.88 Very High Very High Very High
Hypotension 4 98.66 Very High Very High Very High
Cv Unclassified Under Development 4 93.96 High High
Natriuresis 23 91.48 High High
Hypertension 10 90.52 High High
Depression 27 88.64 High High
Hyperalgesia 2 88.28 High High
Pressure Volume 2 Under Development 6 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The diurnal response to ovine corticotropin-releasing factor (CRF-41), arginine vasopressin (AVP), and adrenocorticotropic hormone (ACTH) was studied in rats in which the endogenous release of CRF was blocked by chlorpromazine, morphine sulfate, and pentobarbital sodium.
Negative_regulation (blocked) of Localization (release) of CRF associated with morphine
1) Confidence 0.58 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2844097 Disease Relevance 0 Pain Relevance 0.10
Similarly, morphine (10(-6) M) inhibited acetylcholine (10(-9) M)- and serotonin (10(-7) M)-stimulated CRF-41 release.
Negative_regulation (inhibited) of Localization (release) of CRF-41 associated with serotonin and morphine
2) Confidence 0.58 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.13
However, similar concentrations of morphine inhibited CRF-41 release stimulated by norepinephrine in a dose-dependent manner.
Negative_regulation (inhibited) of Localization (release) of CRF-41 associated with morphine
3) Confidence 0.58 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.04
However, chronic administration of desmethylimipramine and mianserin inhibited LC activation by a hypotensive stress that requires endogenous CRF release, suggesting that they decrease CRF release in the LC.
Negative_regulation (decrease) of Localization (release) of CRF associated with stress, locus ceruleus and hypotension
4) Confidence 0.58 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7859115 Disease Relevance 0.34 Pain Relevance 1.07
On the other hand, cocaine-induced iCRH secretion was inhibited by GABA, a potent inhibitor of CRH secretion, dexamethasone, verapamil, a calcium channel blocker, tetrodotoxin, a sodium channel blocker, and carbamazepine, an antiepileptic and antidepressive agent.
Negative_regulation (inhibitor) of Localization (secretion) of CRH associated with tetrodotoxin, gaba, calcium channel, sodium channel, dexamethasone, carbamazepine and cocaine
5) Confidence 0.57 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.79
Intravenous administration of 0.5 and 2.0 mg/kg cocaine to rats in which the endogenous release of CRF was blocked by chlorpromazine, morphine, and pentobarbital elicited a significant increase in plasma corticosterone concentrations.
Negative_regulation (blocked) of Localization (release) of CRF in plasma associated with morphine and cocaine
6) Confidence 0.57 Published 1987 Journal Peptides Section Abstract Doc Link 2829143 Disease Relevance 0 Pain Relevance 0.40
Finally, tetraethylammonium and apamine also antagonized the inhibition of CRF/AVP-evoked ACTH release by 8-Br-cGMP.
Negative_regulation (inhibition) of Localization (release) of CRF
7) Confidence 0.57 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2169519 Disease Relevance 0 Pain Relevance 0.06
However, in rats with a pharmacological block of the endogenous CRF release, exogenous CRH (0.3 micrograms/kg iv), administered 15 min after a first similar dose, was unable to stimulate pituitary-adrenocortical activity above the level attained with the first peptide injection.
Negative_regulation (block) of Localization (release) of CRF in pituitary
8) Confidence 0.57 Published 1991 Journal Endocrinology Section Abstract Doc Link 2036982 Disease Relevance 0.17 Pain Relevance 0
Hypothalamic CRH secretion, determined by direct RIA, without extraction and reported as pg CRH/MBH per 1 h incubation, was inhibited by ACTH administration in a dose-dependent manner, as demonstrated by a significant negative correlation obtained by linear regression analysis of CRH secretion as a function of ACTH dose.
Negative_regulation (inhibited) of Localization (secretion) of CRH in MBH
9) Confidence 0.56 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9196563 Disease Relevance 0.08 Pain Relevance 0.08
However, the percentage of inhibition of CRH secretion was higher at 1 and 3 days than at 14 days after ADX.
Negative_regulation (inhibition) of Localization (secretion) of CRH
10) Confidence 0.56 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9196563 Disease Relevance 0.07 Pain Relevance 0.07
Central administration of alpha-melanocyte-stimulating hormone inhibits corticotropin-releasing factor release in adrenalectomized rats.
Negative_regulation (inhibits) of Localization (release) of corticotropin-releasing factor in melanocyte
11) Confidence 0.55 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 7970145 Disease Relevance 0 Pain Relevance 0.08
To block endogenous corticotropin releasing factor secretion and nonspecific systemic responses, both groups were pretreated with chlorpromazine, morphine, and sodium pentobarbital anesthesia before measurement of ACTH responses to corticotropin releasing factor and vasopressin infusion.
Negative_regulation (block) of Localization (secretion) of corticotropin releasing factor associated with anesthesia and morphine
12) Confidence 0.53 Published 1986 Journal Hypertension Section Abstract Doc Link 3009324 Disease Relevance 0.17 Pain Relevance 0.19
Isoproterenol also had a potent inhibitory effect at 0.01-100 nM concentrations, and a high dose of phenylephrine (10 nM) inhibited I-CRF release.
Negative_regulation (inhibited) of Localization (release) of I-CRF
13) Confidence 0.50 Published 1987 Journal Life Sci. Section Abstract Doc Link 2882402 Disease Relevance 0 Pain Relevance 0.18
Pretreatment of CPZ-MS-Nb animals with 20 micrograms dexamethasone 4 h before assay abolished the CRF-induced hormone secretion.
Negative_regulation (abolished) of Localization (secretion) of CRF associated with dexamethasone
14) Confidence 0.49 Published 1982 Journal Endocrinology Section Abstract Doc Link 6274623 Disease Relevance 0 Pain Relevance 0.13
The results suggest that opioid substances stimulate HPA activity by depressing the activity of the adrenergic pathways which inhibit the secretion of CRF.
Negative_regulation (inhibit) of Localization (secretion) of CRF associated with opioid
15) Confidence 0.49 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.33 Pain Relevance 0.45
The ability of the neurohypophyseal hormones and related synthetic peptides to potentiate the action of synthetic ovine corticotropin releasing factor (CRF-41) was examined using male rats whose endogenous CRF release was blocked with chlorpromazine, morphine and nembutal.
Negative_regulation (blocked) of Localization (release) of CRF associated with morphine
16) Confidence 0.43 Published 1984 Journal Life Sci. Section Abstract Doc Link 6332965 Disease Relevance 0 Pain Relevance 0.15
Inhibition of corticotrophin releasing factor secretion in the pentobarbitone-morphine-treated rat.
Negative_regulation (Inhibition) of Localization (secretion) of corticotrophin releasing factor associated with morphine
17) Confidence 0.43 Published 1984 Journal Eur. J. Pharmacol. Section Title Doc Link 6325216 Disease Relevance 0.07 Pain Relevance 0.47
Stimulation and inhibition of corticotrophin releasing factor secretion by beta endorphin.
Negative_regulation (inhibition) of Localization (secretion) of corticotrophin releasing factor associated with narcan
18) Confidence 0.43 Published 1986 Journal Neuroendocrinology Section Title Doc Link 2936971 Disease Relevance 0 Pain Relevance 0.42
The stimulatory effect on CRF-41 release induced by veratridine (10(-6) M) was inhibited by approximately 50% in the presence of morphine.
Negative_regulation (inhibited) of Localization (release) of CRF-41 associated with morphine
19) Confidence 0.43 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.19
KCl (28 nM)-mediated CRF-41 release was also significantly inhibited by morphine.
Negative_regulation (inhibited) of Localization (release) of CRF-41 associated with morphine
20) Confidence 0.43 Published 1989 Journal Endocrinology Section Abstract Doc Link 2539975 Disease Relevance 0 Pain Relevance 1.24

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