INT55141

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.81
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (P4hb) endoplasmic reticulum (P4hb) plasma membrane (P4hb)
Anatomy Link Frequency
Paw 1
P4hb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 4 98.68 Very High Very High Very High
cytokine 1 88.56 High High
Inflammation 3 85.40 High High
Arthritis 2 76.16 Quite High
Pain 1 64.88 Quite High
anesthesia 3 45.32 Quite Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 33 95.60 Very High Very High Very High
Bronchospasm 57 85.52 High High
INFLAMMATION 3 85.40 High High
Arthritis 2 76.16 Quite High
Hepatitis 4 75.00 Quite High
Paralysis 12 5.00 Very Low Very Low Very Low
Shock 9 5.00 Very Low Very Low Very Low
Asthma 9 5.00 Very Low Very Low Very Low
Respiratory Failure 6 5.00 Very Low Very Low Very Low
Obstructive Airway Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mechanism of the production of the anti-PDI autoantibody is unclear, the occurrence of anti-PDI antibody correlated with high serum GPT activities.
Gene_expression (production) of PDI
1) Confidence 0.56 Published 1994 Journal J Toxicol Sci Section Abstract Doc Link 7966453 Disease Relevance 0.07 Pain Relevance 0.18
Lyprinol also decreased the expressions of 5 other proteins: protein-o-mannosyl- transferase 2 (PMT-2), Tdrd 7, telethonin, dynactin 2 and protein disulfide isomerase (PDI or glucose-regulated protein (GRP)).
Gene_expression (expressions) of PDI
2) Confidence 0.55 Published 2008 Journal Inflammopharmacology Section Abstract Doc Link 18759077 Disease Relevance 0.31 Pain Relevance 0.30
The anti-PDI antibody was not detected in rats treated with diethylmaleate alone.
Neg (not) Gene_expression (detected) of PDI
3) Confidence 0.49 Published 1994 Journal J Toxicol Sci Section Abstract Doc Link 7966453 Disease Relevance 0.07 Pain Relevance 0.19
This was true for both absolute tidal pressure swings and the pressureĀ–time products for both Ppl and Pdi.
Gene_expression (products) of Pdi
4) Confidence 0.09 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0 Pain Relevance 0
PressureĀ–time products of Ppl and transdiaphragmatic pressure (Pdi) were calculated as the area of the inspiratory portion of the pressure curve (Fig. 2).
Gene_expression (products) of Pdi
5) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0 Pain Relevance 0
COPD = chronic obstructive pulmonary disease; CPAP = continuous positive airway pressure; EELV = end-expiratory lung volume; EPAP = expiratory positive airway pressure; IPAP = inspiratory positive airway pressure; Pabd = abdominal pressure; Paw = airway pressure; Pdi = transdiaphragmatic pressure; PEEP = positive end-expiratory pressure; Ppl = pleural pressure; Vt = tidal ventilation.



Gene_expression (pressure) of Pdi in Paw associated with chronic obstructive pulmonary disease
6) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420031 Disease Relevance 0.34 Pain Relevance 0

General Comments

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