INT55162

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Context Info
Confidence 0.30
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.82
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1, RELA) cytoplasm (NFKB1, RELA) cytosol (NFKB1, RELA)
nucleus (NFKB1, RELA) mitochondrion (NFKB1) aging (RELA)
Anatomy Link Frequency
monocytes 3
T cells 1
NFKB1 (Homo sapiens)
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 3 99.20 Very High Very High Very High
cytokine 49 99.00 Very High Very High Very High
Inflammatory mediators 11 96.72 Very High Very High Very High
Hippocampus 7 93.12 High High
cerebral cortex 1 91.28 High High
cINOD 8 87.20 High High
Inflammatory response 8 81.40 Quite High
Neurotransmitter 1 80.16 Quite High
Inflammation 62 79.76 Quite High
Glutamate 1 78.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 96.72 Very High Very High Very High
Necrosis 12 94.96 High High
Cancer 38 94.60 High High
Disease 30 92.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 142 85.76 High High
Adhesions 7 82.84 Quite High
Stress 3 61.44 Quite High
Aging 21 50.00 Quite Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
NF-kappa B Binding (heterodimer) of p65 in monocytes associated with inflammatory mediators
1) Confidence 0.30 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.54 Pain Relevance 0.27
Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
p50 Binding (heterodimer) of Nuclear factor kappa B in monocytes associated with inflammatory mediators
2) Confidence 0.30 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.54 Pain Relevance 0.27
Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
p50 Binding (heterodimer) of p65 in monocytes associated with inflammatory mediators
3) Confidence 0.28 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.54 Pain Relevance 0.27
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
NF-kappa B Binding (heterodimer) of p65
4) Confidence 0.23 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
p50 Binding (heterodimer) of p65
5) Confidence 0.12 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
p50 Binding (heterodimer) of p65
6) Confidence 0.12 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
p50 Binding (heterodimer) of p65
7) Confidence 0.12 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
B as a heterodimer of the DNA-binding subunits p50 and p65, complexed with I?
p50 Binding (heterodimer) of p65
8) Confidence 0.06 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0.16 Pain Relevance 0.27
B in T cells is predominantly composed of p65 or c-Rel bound to p50 or p52, whereas in MDMs, Rel B replaces p65 [97-100].
p50 Binding (bound) of p65 in T cells
9) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.40 Pain Relevance 0
While transcriptionally active homodimers of both p50 and p65 can form, the p50/65 heterodimer is preferentially formed in most cell types [45].
p50 Binding (homodimers) of p65
10) Confidence 0.01 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.28 Pain Relevance 0.11

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