INT55168

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 55
Total Number 59
Disease Relevance 22.94
Pain Relevance 13.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
MNCs 7
monocytes 4
THP-1 2
neutrophils 2
liver 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 100 100.00 Very High Very High Very High
qutenza 21 99.84 Very High Very High Very High
Morphine 28 99.80 Very High Very High Very High
narcan 15 99.64 Very High Very High Very High
dexamethasone 15 99.00 Very High Very High Very High
Opioid 7 98.68 Very High Very High Very High
cytokine 176 98.66 Very High Very High Very High
tramadol 7 98.60 Very High Very High Very High
Dynorphin 4 98.40 Very High Very High Very High
Inflammation 201 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 284 100.00 Very High Very High Very High
Nicotine Addiction 80 100.00 Very High Very High Very High
Alagille Syndrome 12 99.84 Very High Very High Very High
Colon Cancer 251 99.20 Very High Very High Very High
Necrosis 36 98.96 Very High Very High Very High
Cancer 167 98.78 Very High Very High Very High
Cirrhosis 5 98.46 Very High Very High Very High
Apoptosis 139 97.96 Very High Very High Very High
Leukemia 15 95.80 Very High Very High Very High
Injury 47 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a weak interaction between NFkB -94ins/del polymorphism and intake of red and processed meat in relation to CRC risk (Table 3).
NFkB Binding (interaction) of associated with colon cancer
1) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.56 Pain Relevance 0.12
We found no interaction between the NFkB -94ins/del polymorphism and smoking status, suggesting that the carcinogen exposure from tobacco smoke, which comes from ingestion of inhaled tobacco smoke particles, is less than the carcinogen exposure from ingestion of red and processed meat.
NFkB Neg (no) Binding (interaction) of associated with nicotine addiction
2) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.62 Pain Relevance 0.06
Furthermore, interaction between meat and NFkB may be caused by a lower activation of NFkB del-allele relative to the ins-allele resulting in a high load of reactive oxygen species provided by heme degradation and which may contribute to carcinogenesis [60].
NFkB Binding (interaction) of
3) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.40 Pain Relevance 0
Similarly, decreased NF-kappa B DNA binding and transcriptional activities were detected in cells treated with the combination compared with the single agents, demonstrating cooperative targeting of the NF-kappa B pathway.
NF-kappa B Binding (binding) of
4) Confidence 0.47 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.49 Pain Relevance 0.37
The NO synthase inhibitors Nomega-nitro-l-arginine-methyl-esther and Nomega-nitro-l-arginine completely abolished the morphine-induced attenuation of NF-kappaB nuclear binding, demonstrating that the inhibitory action is mediated by NO release.
NF-kappaB Binding (binding) of
5) Confidence 0.47 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Morphine causes immunosuppression, at least in part, via the NO-stimulated depression of NF-kappaB nuclear binding.


NF-kappaB Binding (binding) of
6) Confidence 0.47 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism.
NF-kappaB Binding (binding) of in neutrophils associated with morphine
7) Confidence 0.47 Published 2000 Journal Anesthesiology Section Title Doc Link 10839919 Disease Relevance 0.19 Pain Relevance 0.37
Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.
NF-kappaB Binding (binding) of associated with qutenza
8) Confidence 0.42 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.33 Pain Relevance 0.10
Low pH resulted in enhancement of H. pylori-induced NF-kappaB nuclear binding.
NF-kappaB Binding (binding) of
9) Confidence 0.41 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.76 Pain Relevance 0.12
NF-kappaB DNA-binding in gastric epithelial cells dramatically increased when the pH of the culture medium decreased.
NF-kappaB Binding (binding) of in epithelial cells
10) Confidence 0.41 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.98 Pain Relevance 0.15
Similar to H. pylori, low pH potently and independently augments NF-kappaB nuclear binding in AGS cells and such activation appears to be mediated through MEK1-dependant signaling pathways.
NF-kappaB Binding (binding) of in AGS associated with alagille syndrome
11) Confidence 0.41 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.65 Pain Relevance 0.08
Increases in NF-kappaB nuclear binding were paralleled by decreasing amounts of cytosolic IkappaB-alpha.
NF-kappaB Binding (binding) of
12) Confidence 0.41 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.92 Pain Relevance 0.14
Addition of recombinant human PARP-1 protein to nuclear extracts of MNCs significantly increased the DNA binding activity of NF-kappaB.
NF-kappaB Binding (activity) of in MNCs
13) Confidence 0.38 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.05 Pain Relevance 0
Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding.
NF-kappaB Binding (binding) of associated with qutenza
14) Confidence 0.38 Published 2002 Journal Arch. Pharm. Res. Section Abstract Doc Link 12214859 Disease Relevance 0.48 Pain Relevance 0.53
Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements.
NF-kappaB Binding (interact) of associated with inflammation and cinod
15) Confidence 0.36 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049733 Disease Relevance 0.42 Pain Relevance 0.25
There was no interaction between use of nonsteroid antiinflammatory drugs (NSAID) or smoking status and NFkB, PXR or LXR polymorphisms.


NFkB Neg (no) Binding (interaction) of associated with nicotine addiction, inflammation and cinod
16) Confidence 0.36 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2949803 Disease Relevance 0.89 Pain Relevance 0.16
Parthenolide treatment also dose-dependently increased the amount of the NF-kappa B inhibitory protein, I kappa B-alpha, and decreased NF-kappa B DNA binding activity.
NF-kappa B Binding (activity) of
17) Confidence 0.35 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.52 Pain Relevance 0.35
Parthenolide treatment also dose-dependently increased the amount of the NF-kappa B inhibitory protein, I kappa B-alpha, and decreased NF-kappa B DNA binding activity.
NF-kappa B Binding (binding) of
18) Confidence 0.35 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.52 Pain Relevance 0.34
In the electrophoretic mobility shift assay, dexamethasone and rofecoxib dose-dependently inhibited the DNA binding activity of NF-kappaB in stimulated monocytes, whereas indomethacin failed to inhibit the LPS-evoked one.
NF-kappaB Binding (binding) of in monocytes associated with dexamethasone
19) Confidence 0.35 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.46
In the electrophoretic mobility shift assay, dexamethasone and rofecoxib dose-dependently inhibited the DNA binding activity of NF-kappaB in stimulated monocytes, whereas indomethacin failed to inhibit the LPS-evoked one.
NF-kappaB Binding (activity) of in monocytes associated with dexamethasone
20) Confidence 0.35 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464079 Disease Relevance 0.66 Pain Relevance 0.46

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