INT55169

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 4.91
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
mere 4
nucleus 2
dentate gyrus 1
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 2 98.40 Very High Very High Very High
qutenza 6 97.16 Very High Very High Very High
Catechol-O-methyltransferase 333 97.12 Very High Very High Very High
Hippocampus 7 95.60 Very High Very High Very High
cytokine 112 93.68 High High
Inflammation 164 92.96 High High
Inflammatory response 29 81.40 Quite High
tetrodotoxin 1 65.12 Quite High
Inflammatory mediators 5 51.16 Quite High
antagonist 8 50.00 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 147 99.60 Very High Very High Very High
Apoptosis 234 96.32 Very High Very High Very High
Anaplastic Astrocytoma 24 94.12 High High
INFLAMMATION 219 92.96 High High
Respiratory Syncytial Virus 116 89.92 High High
Htlv Types I And Ii 4 88.44 High High
Repression 17 87.84 High High
Death 83 82.96 Quite High
Adhesions 127 82.84 Quite High
Malignant Neoplastic Disease 24 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
nuclear re-localization is expected to inhibit p65 binding.
p65 Binding (binding) of
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
enhances promoter clearance in the nucleus [31,32] and recruits and mediates the phosphorylation of proteins [35], allowing binding of p65 to ?
p65 Binding (binding) of in nucleus
2) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
p65 Binding (activity) of associated with qutenza
3) Confidence 0.35 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.58 Pain Relevance 0.44
B1 p50 oligonucleotides had no effect. 3) Simultaneous incubation with antisense RelA p65 and NF-?
p65 Neg (no) Binding (incubation) of
4) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Expression of ICAM-1 was 90, 80, 63, and 49% after incubation with antisense RelA p65 and NF-?
p65 Binding (incubation) of
5) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
RelA Binding (mere) of in mere
6) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
M/mL and 73, 73, and 70% after incubation with antisense RelA p65 and NF-?
RelA Binding (/) of
7) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The expression of ICAM-1 was 88, 85, and 91% after incubation with antisense RelA p65 and NF-?
p65 Binding (incubation) of
8) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Expression of ICAM-1 was 90, 80, 63, and 49% after incubation with antisense RelA p65 and NF-?
RelA Binding (incubation) of
9) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
p65 Binding (addition) of in mere
10) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
The expression of ICAM-1 was 102, 83, and 85% after incubation with antisense RelA p65 and NF-?
RelA Binding (incubation) of
11) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The expression of ICAM-1 was 102, 83, and 85% after incubation with antisense RelA p65 and NF-?
p65 Binding (incubation) of
12) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 70, 42, and 38% after incubation with antisense RelA p65 and NF-?
RelA Binding (/) of
13) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
B1 p50 oligonucleotides had no effect. 3) Simultaneous incubation with antisense RelA p65 and NF-?
RelA Neg (no) Binding (incubation) of
14) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 70, 42, and 38% after incubation with antisense RelA p65 and NF-?
p65 Binding (/) of
15) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 73, 73, and 70% after incubation with antisense RelA p65 and NF-?
p65 Binding (/) of
16) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
p65 Binding (mere) of in mere
17) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
RelA Binding (addition) of in mere
18) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
The expression of ICAM-1 was 88, 85, and 91% after incubation with antisense RelA p65 and NF-?
RelA Binding (incubation) of
19) Confidence 0.34 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Predominantly a heterodimeric complex of two polypeptides (p65/RelA and p50), NF-?
RelA Binding (complex) of
20) Confidence 0.28 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.26 Pain Relevance 0.05

General Comments

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