INT55170

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 9
Speculated 8
Reported most in Abstract
Documents 97
Total Number 106
Disease Relevance 52.75
Pain Relevance 23.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
lymphocytes 4
endothelial cells 4
stromal cells 3
T-lymphocytes 3
ileum 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 495 100.00 Very High Very High Very High
cINOD 95 100.00 Very High Very High Very High
Morphine 37 100.00 Very High Very High Very High
COX2 16 100.00 Very High Very High Very High
Substantia nigra 2 100.00 Very High Very High Very High
Angina 45 99.98 Very High Very High Very High
glial activation 2 99.96 Very High Very High Very High
narcan 2 99.80 Very High Very High Very High
Neuropathic pain 10 99.72 Very High Very High Very High
Inflammation 679 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 860 100.00 Very High Very High Very High
Repression 19 100.00 Very High Very High Very High
Cv General 3 Under Development 45 99.98 Very High Very High Very High
Neuropathic Pain 10 99.72 Very High Very High Very High
Colon Cancer 189 99.60 Very High Very High Very High
Skin Cancer 43 99.60 Very High Very High Very High
Cancer 308 99.52 Very High Very High Very High
Pancreatitis 54 99.40 Very High Very High Very High
Necrosis 92 99.28 Very High Very High Very High
Meningoencephalitis 8 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NF-kappaB and metalloproteinases was examined in either HT-29 cells treated with IL-1beta and/or 5-aminosalicylic acid.
Spec (examined) Gene_expression (expression) of NF-kappaB in HT-29
1) Confidence 0.77 Published 2009 Journal Dig Liver Dis Section Body Doc Link 18976971 Disease Relevance 0.19 Pain Relevance 0
Indeed, deregulated NF-kappaB expression is a characteristic phenomenon in several inflammatory diseases and NF-kappaB has become a major target in drug discovery.
Gene_expression (expression) of NF-kappaB associated with inflammation and disease
2) Confidence 0.77 Published 2009 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 19275691 Disease Relevance 0.91 Pain Relevance 0.41
Activation of NK-1R could then impact NF-kappaB expression and therefore may be an important participant in the effect of morphine on immune responses in the central nervous system.
Gene_expression (expression) of NF-kappaB in central nervous system associated with central nervous system and morphine
3) Confidence 0.75 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0 Pain Relevance 1.40
Conversely, a high fat diet is capable of inducing the activation and expression of certain transcription factors like NF-kappa B and hence inflammation (Liao et al., 1993), which might lead to increased cellular stress.
Gene_expression (expression) of NF-kappa B in fat associated with stress and inflammation
4) Confidence 0.75 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 0.80 Pain Relevance 0.09
Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.
Gene_expression (production) of p50
5) Confidence 0.75 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.45 Pain Relevance 0.22
In order to examine the role of NFkappabeta in the pathophysiology of CFS, this study examines the production of NFkappabeta p50 in unstimulated, 10 ng/mL TNF-alpha (tumor necrosis factor alpha) and 50 ng/mL PMA (phorbolmyristate acetate) stimulated peripheral blood lymphocytes of 18 unmedicated patients with CFS and 18 age-sex matched controls.
Spec (examines) Gene_expression (production) of p50 in lymphocytes associated with necrosis and cancer
6) Confidence 0.75 Published 2007 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 17693979 Disease Relevance 0.78 Pain Relevance 0.09
TNF alpha production in morphine-treated human neural cells is NF-kappaB-dependent.
Gene_expression (production) of NF-kappaB-dependent in neural associated with narcan and morphine
7) Confidence 0.75 Published 2009 Journal J Neuroimmune Pharmacol Section Title Doc Link 19023660 Disease Relevance 0.39 Pain Relevance 0.78
Expression of nitrotyrosine proteins and activity of nuclear factor kappaB (NF-kappaB) were analyzed by Western blot and immunocytochemistry.
Spec (analyzed) Gene_expression (Expression) of NF-kappaB
8) Confidence 0.74 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
Expression of nitrotyrosine proteins and activity of nuclear factor kappaB (NF-kappaB) were analyzed by Western blot and immunocytochemistry.
Spec (analyzed) Gene_expression (Expression) of nuclear factor kappaB
9) Confidence 0.74 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
Importantly, it has been observed that Vpr downregulates NF-kappaB and the production of pro-inflammatory cytokines such as TNF-alpha, and IL-12.
Gene_expression (production) of NF-kappaB associated with inflammation and cytokine
10) Confidence 0.73 Published 2004 Journal DNA Cell Biol. Section Abstract Doc Link 15142381 Disease Relevance 0.96 Pain Relevance 0.38
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
Gene_expression (expression) of nuclear factor kappa B in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
11) Confidence 0.73 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.81 Pain Relevance 0.30
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
Gene_expression (expression) of NF-kappaB in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
12) Confidence 0.73 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.81 Pain Relevance 0.30
Immunofluorescene of its p65 subunit revealed that pre-incubation with hCG-A strongly decreased TNF-alpha-dependent nuclear expression of NF-kappaB.
Gene_expression (expression) of NF-kappaB
13) Confidence 0.73 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.64 Pain Relevance 0.30
Nuclear NF-kappaB and cytoplasmic IkappaB protein levels were determined by electrophoretic mobility shift assay and Western blot, respectively.
Gene_expression (levels) of NF-kappaB
14) Confidence 0.72 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.87 Pain Relevance 0.15
Moreover, inhibition of Akt or nuclear factor-kappaB (NF-kappaB) expression by RNA interference technology also dramatically increased morphine-induced apoptosis.
Gene_expression (expression) of nuclear factor-kappaB associated with apoptosis and morphine
15) Confidence 0.70 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.06 Pain Relevance 0.91
Moreover, inhibition of Akt or nuclear factor-kappaB (NF-kappaB) expression by RNA interference technology also dramatically increased morphine-induced apoptosis.
Gene_expression (expression) of NF-kappaB associated with apoptosis and morphine
16) Confidence 0.70 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.05 Pain Relevance 0.90
We investigated the expression of the active forms of NF-kappaB, JNK and p38 MAPK using immunohistochemistry with activation specific antibodies in human colonic adenomas.
Spec (investigated) Gene_expression (expression) of NF-kappaB associated with adenoma
17) Confidence 0.69 Published 2001 Journal Oncogene Section Abstract Doc Link 11314016 Disease Relevance 0.86 Pain Relevance 0.22
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps.
Gene_expression (expressed) of NF-kappaB in stroma associated with cox2 and adenomatous polyps
18) Confidence 0.69 Published 2001 Journal Oncogene Section Title Doc Link 11314016 Disease Relevance 0.84 Pain Relevance 0.32
The clinical documentation with regard to the efficiency and safety of NF-kappaB inhibition is still limited, but experimental evidence strongly suggests that NF-kappaB inhibition should be further investigated in human AML.
Neg (inhibition) Gene_expression (inhibition) of NF-kappaB associated with acute myeloid leukemia
19) Confidence 0.68 Published 2009 Journal Crit Rev Oncog Section Abstract Doc Link 20136626 Disease Relevance 0.78 Pain Relevance 0
The two studies may suggest that a lower NFkB response by the NFkB del-allele carriers after stimulation by intestinal carcinogens may lead to a lower expression of the MDR1 [21] and, thus, a lower transport activity and, eventually, an impaired defence against intestinal uptake of luminal carcinogens compared to homozygous ins-allele carriers.
Gene_expression (response) of NFkB
20) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.20 Pain Relevance 0

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