INT55171

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 80
Total Number 80
Disease Relevance 17.17
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
nucleus 3
T cells 2
monocytes 1
neurons 1
pancreas 1
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 222 98.52 Very High Very High Very High
Chronic pancreatitis 34 97.32 Very High Very High Very High
Inflammatory response 68 94.96 High High
cytokine 401 93.68 High High
Inflammation 585 93.28 High High
Angina 90 93.04 High High
cINOD 39 84.24 Quite High
Kinase C 15 84.24 Quite High
aspirin 187 82.56 Quite High
Inflammatory stimuli 11 78.72 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 143 99.60 Very High Very High Very High
Pancreatitis 34 97.32 Very High Very High Very High
Pancreatic Cancer 10 96.80 Very High Very High Very High
Skin Cancer 9 96.32 Very High Very High Very High
Adhesions 330 96.08 Very High Very High Very High
Adenocarcinoma 3 95.88 Very High Very High Very High
Apoptosis 309 95.16 Very High Very High Very High
Melanoma 3 95.08 Very High Very High Very High
INFLAMMATION 714 94.96 High High
Premature Aging 3 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.
Gene_expression (production) of p65
1) Confidence 0.75 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.45 Pain Relevance 0.22
In the present study, we found a close positive correlation between NF-kappaB p65 and Shh expression in surgically resected pancreas specimens, including specimens of chronic pancreatitis and pancreatic adenocarcinoma.
Gene_expression (expression) of p65 in pancreas associated with adenocarcinoma and chronic pancreatitis
2) Confidence 0.75 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16849549 Disease Relevance 0.93 Pain Relevance 0.18
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Gene_expression (expression) of p65
3) Confidence 0.75 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
In the study presented we added antisense RelA p65 and NF-?
Gene_expression (antisense) of p65
4) Confidence 0.71 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.11
After adding simultaneously antisense RelA p65 and NF-?
Gene_expression (antisense) of RelA
5) Confidence 0.71 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.10 Pain Relevance 0
In the study presented we added antisense RelA p65 and NF-?
Gene_expression (antisense) of RelA
6) Confidence 0.71 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.11
The NF-kappaB complex was composed of p50 and p65 subunits and its activation required inhibitor of NF-kappaBalpha degradation.
Gene_expression (composed) of p65
7) Confidence 0.65 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17896809 Disease Relevance 0.15 Pain Relevance 0
Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.
Gene_expression (production) of p65
8) Confidence 0.65 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.45 Pain Relevance 0.22
and RelA were diluted 1?
Gene_expression (diluted) of RelA
9) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.28 Pain Relevance 0.04
B (p50, p65/RelA, and p52/RelB) by ubiquitin-mediated degradation of inhibitor-?
Gene_expression (/) of RelA
10) Confidence 0.65 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.54 Pain Relevance 0
B1 p50 and RelA p65 oligonucleotides to HUVEC and HCAEC only RelA p65 had an inhibitory effect on TNF-?
Gene_expression (only) of p65
11) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
A predominance of RelA p65 in the dimers of the NF-?
Gene_expression (predominance) of RelA
12) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
B1 p50 and RelA p65 oligonucleotides to HUVEC and HCAEC only RelA p65 had an inhibitory effect on TNF-?
Gene_expression (only) of RelA
13) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
B1 p50 and RelA p65 oligonucleotides to HUVEC and HCAEC only RelA p65 had an inhibitory effect on TNF-?
Gene_expression (had) of p65
14) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
M/mL and 116, 129, and 107% after incubation with antisense RelA p65 oligonucleotides in a concentration of 10, 20, and 30 ?
Gene_expression (oligonucleotides) of RelA
15) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
A predominance of RelA p65 in the dimers of the NF-?
Gene_expression (predominance) of p65
16) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
M/mL and 74, 79, and 82% after incubation with antisense RelA p65 oligonucleotides in a concentration of 10, 20, and 30 ?
Gene_expression (oligonucleotides) of RelA
17) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
M/mL and 116, 129, and 107% after incubation with antisense RelA p65 oligonucleotides in a concentration of 10, 20, and 30 ?
Gene_expression (oligonucleotides) of p65
18) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The expression of ICAM-1 was 132, 129, and 113% after incubation with antisense p65 oligonucleotides in a concentration of 1, 2, and 4 ?
Gene_expression (oligonucleotides) of p65
19) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
B1 p50 and RelA p65 oligonucleotides to HUVEC and HCAEC only RelA p65 had an inhibitory effect on TNF-?
Gene_expression (oligonucleotides) of p65
20) Confidence 0.62 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0

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