INT55174

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Context Info
Confidence 0.25
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (REL) DNA binding (REL)
REL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 99.44 Very High Very High Very High
Inflammation 85 99.10 Very High Very High Very High
Dynorphin 2 98.40 Very High Very High Very High
rheumatoid arthritis 1 84.56 Quite High
Inflammatory response 17 79.52 Quite High
deep brain stimulation 57 56.92 Quite High
Enkephalin 1 25.00 Low Low
Thalamus 31 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 108 99.10 Very High Very High Very High
Death 6 98.10 Very High Very High Very High
Disease 78 85.68 High High
Rheumatoid Arthritis 2 84.56 Quite High
Apoptosis 2 80.16 Quite High
Colon Cancer 4 75.00 Quite High
Infection 3 66.56 Quite High
Neurodegenerative Disease 1 53.76 Quite High
Cancer 1 53.16 Quite High
Cognitive Disorder 3 16.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p50 homodimer, but not p65/c-Rel and NF-kappa B, bound specifically to a DNA-motif within the dynorphin A-encoding gene sequence.
c-Rel Binding (bound) of associated with dynorphin
1) Confidence 0.25 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.05 Pain Relevance 0.09
The genome-wide transcriptional responses of inflammation are usually focused on the known functional interactions of the master switch proteins, such as Rel or NF-?
Rel Binding (interactions) of associated with inflammation
2) Confidence 0.18 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 1.00 Pain Relevance 0.31
Cell death does correlate with alterations in NF-kappa B activity: the NSAIDs, butyrate and H2O2 enhance c-Rel complex formation by TNF-alpha and provide an overall enhancement of NF-kappa B activation by Fas.
c-Rel Binding (formation) of associated with cinod and death
3) Confidence 0.17 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.93 Pain Relevance 0.30
One way of implementing such a cost function is to integrate the current coming out of the stimulator, IDBS, and subtract this weighted integral from the reliability, Rel, as


Rel Binding (integrate) of
4) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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