INT5518

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.42
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pomc, Crh) extracellular space (Pomc, Crh) extracellular region (Pomc, Crh)
response to stress (Crh) cell-cell signaling (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
melanocyte 2
Pomc (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 8 97.20 Very High Very High Very High
Endogenous opioid 1 96.24 Very High Very High Very High
Opioid 6 95.36 Very High Very High Very High
narcan 11 90.60 High High
opiate 2 81.80 Quite High
Calcium channel 2 63.24 Quite High
opioid receptor 1 38.08 Quite Low
Disease Link Frequency Relevance Heat
Hypoglycemia 5 79.44 Quite High
Stress 4 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, beta-endorphin (EP) has been thought to inhibit CRF release in vivo and in vitro.
beta-endorphin Negative_regulation (inhibit) of CRF
1) Confidence 0.36 Published 1992 Journal Endocrinology Section Abstract Doc Link 1311237 Disease Relevance 0.28 Pain Relevance 0.10
As has been previously shown for IL-1 and IL-6, IL-2-induced CRF release was blocked by alpha-melanocyte-stimulating hormone (alpha-MSH), which at high concentrations also reduced basal CRF release.
alpha-melanocyte-stimulating hormone Negative_regulation (blocked) of CRF release in melanocyte
2) Confidence 0.12 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.07 Pain Relevance 0.58
As has been previously shown for IL-1 and IL-6, IL-2-induced CRF release was blocked by alpha-melanocyte-stimulating hormone (alpha-MSH), which at high concentrations also reduced basal CRF release.
alpha-melanocyte-stimulating hormone Negative_regulation (reduced) of CRF release in melanocyte
3) Confidence 0.12 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.07 Pain Relevance 0.58

General Comments

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