INT55185

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 4.43
Pain Relevance 7.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 4
neuronal 1
cerebrum 1
bands 1
cerebellum 1
Sert1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 102 100.00 Very High Very High Very High
Dopamine 38 100.00 Very High Very High Very High
cocaine 176 99.58 Very High Very High Very High
antidepressant 7 99.58 Very High Very High Very High
tolerance 24 99.24 Very High Very High Very High
antagonist 4 99.24 Very High Very High Very High
sSRI 49 98.78 Very High Very High Very High
Neurotransmitter 6 97.04 Very High Very High Very High
Raphe 52 96.28 Very High Very High Very High
tricyclic antidepressant 7 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 6 99.12 Very High Very High Very High
Gliosis 35 98.12 Very High Very High Very High
Urological Neuroanatomy 79 96.00 Very High Very High Very High
Depression 7 95.60 Very High Very High Very High
Anxiety Disorder 162 93.48 High High
Respiratory Tract Infection 3 92.48 High High
Drug Induced Neurotoxicity 140 84.64 Quite High
Sprains And Strains 73 83.68 Quite High
Increased Venous Pressure Under Development 8 82.36 Quite High
Headache 8 78.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SDS-PAGE/Western blots indicate that anti-SERT MoAb recognized two bands of 120 and 73 kDa in both preparations.
anti-SERT Binding (recognized) of in bands
1) Confidence 0.48 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11311448 Disease Relevance 0 Pain Relevance 0.38
Nitrile substituents at the 5 and 7 positions of the indole ring gave high affinity for hSERT, and the preferred cyclopropane stereochemistry was determined to be (1S,2S)-trans.
hSERT Binding (affinity) of
2) Confidence 0.47 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 16162005 Disease Relevance 0 Pain Relevance 0.12
These in vivo studies show that an interaction between MDMA and the serotonin transporter protein (SERT) is the .rst step in toxicity.
SERT Binding (interaction) of associated with toxicity and serotonin
3) Confidence 0.45 Published 2006 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 16510483 Disease Relevance 0.33 Pain Relevance 0.14
The aim of the present study was to study the in vivo effect of various antidepressants on [(3)H]paroxetine binding to SERT in regions of rat brain.
SERT Binding (binding) of in brain associated with antidepressant
4) Confidence 0.42 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18437564 Disease Relevance 0.19 Pain Relevance 0.94
No blockade of DAT or SERT binding was observed after intrastriatal injections of the reversible analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-benzyl nortropane (HD-206), and HD-205 treatment had no effect on D(2)- and mu-opioid-stimulated guanosine 5'-O-(3-[35S]thio)-triphosphate binding in sections from the same animals.
SERT Binding (binding) of associated with opioid
5) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18492949 Disease Relevance 0.09 Pain Relevance 0.26
Similar blockade of SERT binding (using [3H]-citalopram) was observed in the same area.
SERT Binding (binding) of
6) Confidence 0.42 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18492949 Disease Relevance 0.09 Pain Relevance 0.24
Of the seven SSRIs, [3H]-(S)-citalopram, [3H]MADAM, and [11C]DASB displayed significant specific binding to SERT in monkey cerebellum, with Bmax cortex:cerebellum ratios being 17, 3, and 4, respectively.
SERT Binding (binding) of in cerebellum associated with ssri
7) Confidence 0.40 Published 2007 Journal Synapse Section Abstract Doc Link 17657807 Disease Relevance 0 Pain Relevance 0.37
SERT is associated with lipid microdomains, which are required for efficient SERT activity.
SERT Binding (associated) of
8) Confidence 0.39 Published 2008 Journal Life Sci. Section Abstract Doc Link 18482738 Disease Relevance 0.13 Pain Relevance 0.53
Substitution of the indole N-1 position with methyl or ethyl groups gave a 10- to 30-fold decrease in affinity for hSERT, suggesting either a hydrogen-bonding interaction or limited steric tolerance in the region of the indole nitrogen.
hSERT Binding (interaction) of associated with tolerance
9) Confidence 0.36 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 16162005 Disease Relevance 0.08 Pain Relevance 0.27
The dopamine D2 receptor mediates both the rewarding and anxiogenic effects of cocaine [31], and there are interactions between the dopamine D2 receptor and SERT in mediating cocaine reward [32], both of which may modify SERT-/- rat behavioral responses to cocaine.
SERT Binding (interactions) of associated with dopamine and cocaine
10) Confidence 0.35 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.65 Pain Relevance 0.86
Here we provide proof of principle for a rat QTL analysis and identified significant SERT-/- specific QTLs, suggesting that there are genes throughout the genome interacting with the SERT gene in rat.
SERT Binding (interacting) of
11) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.47 Pain Relevance 0.07
Although the specific genetic modifiers remain to be identified, exploration of the QTL regions has lead to candidate genes that plausibly interact with SERT.
SERT Binding (interact) of
12) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.05 Pain Relevance 0
In addition, we have created an overview of candidate genes within QTL regions that may interact with SERT, including genes encoding 1] the 5-HT1D receptor, 2] components of other neurotransmitter systems, or 3] developmental and plasticity proteins.
SERT Binding (interact) of associated with neurotransmitter
13) Confidence 0.34 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.54 Pain Relevance 0.05
The serotonin transporter (SERT) is a target for many clinically significant drugs, such as cocaine, amphetamine, and antidepressants.
SERT Binding (target) of associated with antidepressant, serotonin and cocaine
14) Confidence 0.34 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7969065 Disease Relevance 0 Pain Relevance 0.25
The relationship between the structure of SERT and the binding of substrates and antagonists is virtually unknown, despite a large body of data describing the structure-activity relationships of transporter ligands.
SERT Binding (binding) of in body associated with antagonist
15) Confidence 0.33 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7969065 Disease Relevance 0 Pain Relevance 0.29
Previous studies have shown that the phenylisothiocyanate tropane analog 2-beta-propanoyl-3-beta-(2-naphthyl)-8-[4-isothiocyanato)benzyl]nortropane (HD-205) binds covalently to dopamine and serotonin transporters (DAT and SERT, respectively) in rat brain membranes (Biochem Pharmacol 74:336-344, 2007).
SERT Binding (binds) of in brain associated with dopamine and serotonin
16) Confidence 0.31 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18492949 Disease Relevance 0.07 Pain Relevance 0.14
Furthermore, the present data also indicate that the presence of the mRNA and protein for the neuronal SERT were established in cultured rat astrocytes, and the polypeptide portion of SERT in astrocytes and frontal cortex could be the same gene product.
SERT Binding (presence) of in neuronal associated with urological neuroanatomy
17) Confidence 0.31 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11311448 Disease Relevance 0.10 Pain Relevance 0.17
Compound (+)-12a demonstrated potent hSERT binding (Ki = 0.18 nM) in vitro and was more than 1000-fold less potent at hDAT, hNET, 5-HT1A, and 5-HT6.
hSERT Binding (binding) of
18) Confidence 0.30 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 16162005 Disease Relevance 0.08 Pain Relevance 0.28
The outcome of the ligands as emission tomography tracers was compared in relation with receptor density (Bmax) and/or ligand affinity (Kd) in rat and monkey cerebrum and cerebellum (reference region) membranes. [3H]-(S)-Citalopram and [3H]-(+)-McN5652 display statistically significantly lower affinity, whereas [3H]paroxetine displays statistically significantly higher affinity for SERT in monkey cortex when compared with the rat cerebrum.
SERT Binding (affinity) of in cerebrum
19) Confidence 0.29 Published 2007 Journal Synapse Section Abstract Doc Link 17657807 Disease Relevance 0 Pain Relevance 0.37
The specificity and selectivity of [(18)F]FMe-McN binding to SERT was studied by preinjecting blocking doses of serotonin, norepinephrine, and dopamine transporter inhibitors.
SERT Binding (binding) of associated with dopamine and serotonin
20) Confidence 0.29 Published 2003 Journal Synapse Section Abstract Doc Link 12422372 Disease Relevance 0 Pain Relevance 0.77

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