INT55196

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.82
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion organization (Nrf1) nucleus (Nrf1) DNA binding (Nrf1)
cytoplasm (Nrf1)
Anatomy Link Frequency
cortex 1
hippocampus 1
respiratory 1
Nrf1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 2 99.04 Very High Very High Very High
Hippocampus 26 98.92 Very High Very High Very High
Inflammation 52 94.12 High High
Inflammatory response 1 90.64 High High
cytokine 22 90.40 High High
Inflammatory mediators 1 68.32 Quite High
ischemia 3 64.64 Quite High
GABAergic 18 50.00 Quite Low
addiction 2 50.00 Quite Low
interneuron 10 32.68 Quite Low
Disease Link Frequency Relevance Heat
Shock 152 95.64 Very High Very High Very High
Stress 34 95.28 Very High Very High Very High
INFLAMMATION 45 94.12 High High
Aging 47 91.28 High High
Lung Injury 40 88.64 High High
Pressure And Volume Under Development 2 86.84 High High
Cognitive Disorder 70 82.56 Quite High
Disease 15 75.88 Quite High
Sprains And Strains 13 72.00 Quite High
Stroke 4 67.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NRF1 is activated by increased levels of heme and regulates a large number of genes involved in mitochondrial biogenesis and oxidative stress that overlap with those regulated by PGC-1?
Positive_regulation (activated) of NRF1 associated with stress
1) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.81 Pain Relevance 0
For example, a group of genes upregulated by HTV mechanical ventilation alone (ETF, E2F, Nrf1, CREB, and HIF1) is not found in the list of genes upregulated by LPS [49].
Positive_regulation (upregulated) of Nrf1
2) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 1.23 Pain Relevance 0.20
Lidocaine and quinidine had no significant effect on the activation of the respiratory burst oxidase.
Positive_regulation (activation) of respiratory burst oxidase in respiratory associated with lidocaine
3) Confidence 0.02 Published 1994 Journal Mol. Cell. Biochem. Section Abstract Doc Link 7969098 Disease Relevance 0 Pain Relevance 0.15
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Positive_regulation (increased) of respiratory burst oxidase in cortex associated with hippocampus
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.39 Pain Relevance 0.17
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Positive_regulation (increased) of respiratory burst oxidase in hippocampus associated with hippocampus
5) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.39 Pain Relevance 0.17

General Comments

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