INT55223

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Context Info
Confidence 0.09
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.77
Pain Relevance 5.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 5
immune cells 3
sensory neurons 2
DRG 2
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 318 100.00 Very High Very High Very High
dorsal root ganglion 193 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
Nerve growth factor 19 99.32 Very High Very High Very High
Arthritis 289 99.28 Very High Very High Very High
Inflammation 220 99.12 Very High Very High Very High
substance P 315 98.88 Very High Very High Very High
Sciatic nerve 1 97.20 Very High Very High Very High
anesthesia 1 96.36 Very High Very High Very High
agonist 66 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 198 100.00 Very High Very High Very High
Arthritis 325 99.28 Very High Very High Very High
INFLAMMATION 206 99.12 Very High Very High Very High
Pain 112 83.48 Quite High
Erythermalgia 31 83.04 Quite High
Somatoform Disorder 32 82.40 Quite High
Hyperalgesia 48 81.04 Quite High
Nociception 55 75.56 Quite High
Neurogenic Inflammation 13 74.92 Quite High
Disease 8 51.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.
Regulation (effect) of Gene_expression (expression) of DRG in sensory neurons associated with qutenza
1) Confidence 0.09 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16481104 Disease Relevance 0 Pain Relevance 0.46
However, expression of either P1308L or V1298F increased the number of DRG neurons that fired ?
Regulation (number) of Gene_expression (neurons) of DRG in neurons associated with dorsal root ganglion
2) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.71 Pain Relevance 0.60
Because the expression of BK receptors in cultured DRG neurons can be regulated, for example by nerve growth factor (NGF) [39], we assume that mediators of different sources (such as immune cells and nerve cells) could have a role.
Regulation (regulated) of Gene_expression (expression) of DRG in immune cells associated with dorsal root ganglion, nerve growth factor and bradykinin
3) Confidence 0.03 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.68 Pain Relevance 1.22
The expression of BK–gold-binding sites in the lumbar DRG neurons showed also changes in the course of AIA, but the pattern was different (Fig. 2b).
Regulation (changes) of Gene_expression (expression) of DRG in neurons associated with dorsal root ganglion, bradykinin and arthritis
4) Confidence 0.02 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.31 Pain Relevance 1.10
Because the expression of BK receptors in cultured DRG neurons can be regulated, for example by nerve growth factor (NGF) [39], we assume that mediators of different sources (such as immune cells and nerve cells) could have a role.
Regulation (regulated) of in nerve cells Gene_expression (expression) of DRG in immune cells associated with dorsal root ganglion, nerve growth factor and bradykinin
5) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.68 Pain Relevance 1.22
Our results suggest that electrical activity mediates, in part, the changes in DRG gene expression in response to acute inflammation.
Regulation (changes) of Gene_expression (expression) of DRG gene in DRG associated with inflammation
6) Confidence 0.00 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.40 Pain Relevance 0.55

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