INT55224

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 99
Total Number 102
Disease Relevance 67.55
Pain Relevance 67.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 49
DRG 13
sensory neurons 4
neuronal 4
spinal cord 3
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1900 100.00 Very High Very High Very High
bradykinin 766 100.00 Very High Very High Very High
sodium channel 409 100.00 Very High Very High Very High
hyperexcitability 231 100.00 Very High Very High Very High
Spinal cord 210 100.00 Very High Very High Very High
qutenza 167 100.00 Very High Very High Very High
nav1.8 140 100.00 Very High Very High Very High
chemokine 61 100.00 Very High Very High Very High
medulla 10 100.00 Very High Very High Very High
Nucleus accumbens 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1957 100.00 Very High Very High Very High
Nociception 528 100.00 Very High Very High Very High
Infection 15 100.00 Very High Very High Very High
Herpes Zoster 12 100.00 Very High Very High Very High
Arthritis 840 99.96 Very High Very High Very High
Congenital Pain Insensitivity 14 99.92 Very High Very High Very High
Injury 205 99.82 Very High Very High Very High
Erythermalgia 792 99.80 Very High Very High Very High
INFLAMMATION 873 99.76 Very High Very High Very High
Disease 156 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that increased DRG mRNA production leads to increased alpha 2 delta 1 protein production and subsequent transport by primary afferents to the dorsal horn.
Gene_expression (production) of DRG in dorsal horn associated with dorsal root ganglion and dorsal horn
1) Confidence 0.31 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17367933 Disease Relevance 0.91 Pain Relevance 1.16
The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons.
Gene_expression (expression) of DRG in sensory neurons associated with qutenza
2) Confidence 0.19 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16481104 Disease Relevance 0 Pain Relevance 0.46
METHODS: We performed an RF-DRG procedure in 17 consecutive CP patients with severe hip flexor/adductor spasms accompanied by pain or care-giving difficulties.
Gene_expression (procedure) of RF-DRG in hip
3) Confidence 0.19 Published 2010 Journal BMC Neurol Section Body Doc Link 20569438 Disease Relevance 0.09 Pain Relevance 0
Using current-clamp we show that ranolazine, at a clinically-relevant concentration, attenuates excitability of DRG neurons expressing WT but not the two mutant Nav1.7 channels examined here.
Neg (not) Gene_expression (expressing) of DRG in neurons associated with dorsal root ganglion and nav1.7
4) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 1.06 Pain Relevance 1.26
Our data show a significant ranolazine-induced attenuation of neuronal excitability in DRG neurons expressing WT channels (Figure. 7A).
Gene_expression (expressing) of DRG in neurons associated with dorsal root ganglion and neuronal excitability
5) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.48 Pain Relevance 1.23
We injected the vector into subcutaneous tissue, sciatic nerve, DRGs, and subarachnoid space, and examined EGFP expression in the DRG, spinal cord, and nerve fibers.
Spec (examined) Gene_expression (expression) of DRG in spinal cord associated with sciatic nerve and spinal cord
6) Confidence 0.12 Published 2003 Journal Hum. Gene Ther. Section Abstract Doc Link 12828860 Disease Relevance 0.22 Pain Relevance 0.48
NaV1.7 is preferentially expressed in nociceptive dorsal root ganglia (DRG) neurons and sympathetic ganglia neurons [11-14], and it produces a fast-activating and -inactivating TTX-sensitive (TTX-S) current with a slow recovery from inactivation [12,15].
Gene_expression (expressed) of DRG in neurons associated with nociception
7) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2262064 Disease Relevance 0.92 Pain Relevance 0.43
We also show that ranolazine, at a clinically-relevant concentration, blocks high-frequency firing of DRG neurons expressing wild-type but not mutant channels.


Gene_expression (expressing) of DRG in neurons
8) Confidence 0.11 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2898769 Disease Relevance 0.65 Pain Relevance 1.39
We directly tested whether ranolazine could reduce excitability of DRG neurons transfected with either WT or the hyperexcitability-inducing mutations L858H or V1298F.
Gene_expression (transfected) of DRG in neurons associated with dorsal root ganglion and hyperexcitability
9) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.65 Pain Relevance 0.63
M ranolazine on low frequency firing WT-expressing DRG neurons.
Gene_expression (expressing) of DRG in neurons associated with dorsal root ganglion
10) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.82 Pain Relevance 0.76
The cell suspension was then diluted with DRG media containing 1.5 mg/ml bovine serum albumin and 1.5 mg/ml trypsin inhibitor, 80 ?
Gene_expression (media) of DRG associated with dorsal root ganglion
11) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.34 Pain Relevance 0.22
In contrast, a few WT-expressing DRG neurons showed a high frequency firing phenotype and ranolazine clearly seemed to attenuate the response to the stronger depolarizing current stimuli.
Gene_expression (neurons) of DRG in neurons associated with dorsal root ganglion
12) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.81 Pain Relevance 0.73
Expression of sodium channel Nav1.8 in DRG neurons has also been shown to be essential for the manifestation of mutant Nav1.7-induced neuronal hyperexcitability.
Gene_expression (Expression) of DRG in neuronal associated with sodium channel, nav1.8, hyperexcitability and nav1.7
13) Confidence 0.09 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2898769 Disease Relevance 0.64 Pain Relevance 1.38
The reduction of firing in WT expressing DRG neurons only occurred with stronger current injections which would cause greater depolarization during the current injection.
Gene_expression (expressing) of DRG in neurons associated with dorsal root ganglion
14) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.45 Pain Relevance 1.25
The majority of DRG neurons transfected with WT channels fire 1-2 action potentials in response to a one second depolarizing stimuli, while neurons transfected with Nav1.7 channels carrying IEM or PEPD mutations fire repetitively [14-18].
Gene_expression (transfected) of DRG in neurons associated with action potential, dorsal root ganglion, paroxysmal extreme pain disorder, erythermalgia and nav1.7
15) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.74 Pain Relevance 0.71
M ranolazine treatment on DRG neurons transfected with WT is shown in Figure 7 A.
Gene_expression (transfected) of DRG in neurons associated with dorsal root ganglion
16) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.67 Pain Relevance 0.67
We also used current-clamp recordings to study firing of dorsal root ganglion (DRG) neurons transfected with WT and mutant Nav1.7 channels and show that ranolazine, at a clinically-relevant concentration, blocks high-frequency firing of DRG neurons expressing WT but not mutant Nav1.7 channels.
Neg (not) Gene_expression (expressing) of DRG in DRG associated with ganglion cysts, dorsal root ganglion and nav1.7
17) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.99 Pain Relevance 1.38
Our data suggest that ranalozine can attenuate hyperexcitability of DRG neurons over-expressing wild-type Nav1.7 channels, as occurs in acquired neuropathic and inflammatory pain, and thus merits further study as an alternative to existing non-selective sodium channel blockers.



Gene_expression (expressing) of DRG in neurons associated with ipn, neuropathic pain, sodium channel, nav1.7 and hyperexcitability
18) Confidence 0.09 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2898769 Disease Relevance 0.49 Pain Relevance 1.28
Immunohistochemical analysis of DRG following VZV infection showed the presence of a viral immediate early gene protein (IE62) co-expressed with markers of A- (neurofilament-200; NF-200) and C- (peripherin) afferent sensory neurons.
Gene_expression (co-expressed) of DRG in sensory neurons associated with herpes zoster and infection
19) Confidence 0.08 Published 2005 Journal Pain Section Abstract Doc Link 16213091 Disease Relevance 1.77 Pain Relevance 0.85
Furthermore, MP and DRG neurons were cultured in supernatants from different pancreatic cancer cell lines (PCC) and human pancreatic stellate cells (hPSC) obtained from either CP or PCa tissues.
Gene_expression (neurons) of DRG in DRG
20) Confidence 0.08 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19912545 Disease Relevance 0 Pain Relevance 0

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