INT55236

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.31
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2c) plasma membrane (Htr2c) nucleus (Htr2c)
cytoplasm (Htr2c) signal transducer activity (Htr2c)
Anatomy Link Frequency
choroid plexus 1
Htr2c (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 53 100.00 Very High Very High Very High
fluoxetine 13 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
antinociception 11 99.28 Very High Very High Very High
agonist 40 97.96 Very High Very High Very High
depression 11 93.84 High High
tail-flick 1 82.96 Quite High
antidepressant 1 79.04 Quite High
Kinase C 12 77.04 Quite High
Disease Link Frequency Relevance Heat
Stress 23 100.00 Very High Very High Very High
Psychosis 2 98.24 Very High Very High Very High
Anxiety Disorder 7 94.32 High High
Depression 11 93.84 High High
Schizophrenia 10 93.36 High High
Sprains And Strains 10 89.36 High High
Motor Neuron Diseases 28 88.20 High High
Disease Progression 4 83.84 Quite High
Ataxia 1 83.36 Quite High
Disease 8 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5-HT1C/2 antagonist, ritanserin, the 5-HT3 antagonist, ondansetron, the dopamine D2 receptor antagonist, raclopride, and the alpha 1-adrenoceptor antagonist, prazosin, were also ineffective in modifying the antinociception evoked by 5-HT1A agonists and partial agonists in the hot-plate test.
Regulation (ineffective) of 5-HT1C associated with antinociception, dopamine, antagonist and agonist
1) Confidence 0.44 Published 1994 Journal Pain Section Abstract Doc Link 7970839 Disease Relevance 0.16 Pain Relevance 1.73
Interestingly, the expression of ADAR2 mRNA does not correspond temporally or spatially with its physiological substrates, GluR-B and 5-HT2CR.
Neg (not) Regulation (correspond) of 5-HT2CR
2) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.07 Pain Relevance 0
Several studies suggest that editing of 5-HT2CR mRNA is involved in the pathophysiology of psychotic disorders, and may also regulate efficacy of hallucinogenic and antipsychotic drugs on the serotonin 5-HT2C receptors [21,55,67].
Regulation (editing) of 5-HT2CR associated with psychosis and serotonin
3) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.08 Pain Relevance 0.14
These findings illustrate that 5-HT2C pre-mRNA editing responses to stress and chronic fluoxetine are modulated by the genetic background, as well as the behavioral state of the animal.
Regulation (modulated) of 5-HT2C associated with stress and fluoxetine
4) Confidence 0.26 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659601 Disease Relevance 0.84 Pain Relevance 0.81
Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.
Regulation (alters) of 2C receptor associated with stress and serotonin
5) Confidence 0.17 Published 2007 Journal J. Neurosci. Section Title Doc Link 17287521 Disease Relevance 1.16 Pain Relevance 0.35
Phosphorylation most likely has a prominent role in regulation of the 5-HT2C receptor.
Regulation (regulation) of 5-HT2C receptor
6) Confidence 0.00 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.16
The regulation of the 5-HT2C receptor has been the focus of several studies, but the results have been difficult to interpret for several reasons including the complex pharmacology of this receptor.
Regulation (regulation) of 5-HT2C receptor
7) Confidence 0.00 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.05
We examined the effects of insulin signaling on 5-HT2C receptor function in isolated rat choroid plexus cells.
Spec (examined) Regulation (effects) of 5-HT2C receptor in choroid plexus
8) Confidence 0.00 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.11

General Comments

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