INT55243

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3)
nucleus (Itpr3) transmembrane transport (Itpr3) cytoplasm (Itpr3)
Anatomy Link Frequency
neuronal 2
Itpr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 9 98.92 Very High Very High Very High
Action potential 4 98.64 Very High Very High Very High
tetrodotoxin 1 96.12 Very High Very High Very High
Neuropeptide 2 93.08 High High
Kinase C 18 92.24 High High
Inflammation 12 81.84 Quite High
Lasting pain 2 78.68 Quite High
sodium channel 1 68.88 Quite High
antagonist 4 65.36 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 8 99.36 Very High Very High Very High
INFLAMMATION 8 81.84 Quite High
Pain 2 78.68 Quite High
Body Weight 2 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it appears that sustained afferent nociceptive input induced by FCA injection increased the accumulation of cGMP, insP3 and insP3R density in the spinal cord through increased neuronal activities of functional receptors coupled to major classes of chemical mediators of nociception including neuropeptides and excitatory aminoacids.
Positive_regulation (increased) of Positive_regulation (accumulation) of insP3 in neuronal associated with nociception, neuropeptide and spinal cord
1) Confidence 0.58 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.52 Pain Relevance 0.30
InsP3 accumulation was significantly increased on days 14, 21 and 42 following FCA injection relative to sham-treated time-matched controls.
Positive_regulation (increased) of Positive_regulation (accumulation) of InsP3
2) Confidence 0.51 Published 1994 Journal Pain Section Abstract Doc Link 7970840 Disease Relevance 0.37 Pain Relevance 0.26
A similar increase in IP3 mass was induced by high K+ depolarization but no action potential trains (nor calcium signals) were elicited by prolonged depolarization under current clamp conditions.
Positive_regulation (induced) of Positive_regulation (increase) of IP3 associated with action potential
3) Confidence 0.29 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0 Pain Relevance 0.28
Carbachol-mediated dispersion requires activation of the IP3 receptor [18], suggesting that intracellular Ca2+ stores are accessed following muscarinic receptor activation [17].
Positive_regulation (requires) of Positive_regulation (activation) of IP3 receptor
4) Confidence 0.02 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2225403 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox